Recombinant Mouse NKG2-D type II integral membrane protein (Klrk1)

1. Study demonstrated a novel outcome for Nkg2d in its capacity to promote rather than delay tumor progression in the context of liver carcinogenesis. PMID: 28128200
2. Interaction between NKG2D and endogenous RAE-1delta desensitizes NK cells and impairs antitumor NK responses and tumor rejection. PMID: 29231815
3. Results suggest that NKG2D+CD4+ T cells are involved in the pathogenesis of systemic lupus erythematosus by killing Treg cells in a NKG2D-NKG2DL-dependent manner. PMID: 28455530
4. Loss of NKG2D expression accelerates rejection of cardiac allografts. PMID: 28805342
5. IL-15 mediated up-regulation of the activation receptor NKG2D and its adaptor DAP10 in B-1a cells indicating their essential coupling with IL-15 receptor signaling pathway. PMID: 28235675
6. NKG2DL low expressing cancer cells formed palpable allogeneic tumors in mice within a week after the inoculation, while NKG2DL high expressing cancer cells failed to proliferate and were prevented from forming tumors. PMID: 27448968
7. NKG2D is upregulated, and ROS and caspase-3 are inhibited by Strongylocentrotus nudus egg polysaccharide-enhanced antitumor 5-FU in mice PMID: 27385218
8. High NKG2D expression is associated with the Development of Bronchiolitis Obliterans. PMID: 28251796
9. tumoral NKG2D stimulates cell propagation and immune escape in acute myeloid leukemia cells PMID: 26740330
10. The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3. PMID: 27874833
11. proposed that TLR9 regulates the NF-kappaB-NLRP3-IL-1beta pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity. PMID: 28576980
12. NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors PMID: 27183590
13. data show that NKG2D has a nonredundant role in priming of CD8(+) T cells to produce antiviral cytokines PMID: 28378389
14. NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 complex PMID: 28760883
15. study demonstrates that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor; findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development PMID: 28087665
16. Sirt6 binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels PMID: 27045575
17. These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain PMID: 26110603
18. These results indicate that, unlike in the pancreas, NKG2D-NKG2D ligand interaction does not play a critical role in obesity-induced inflammation in the adipose tissue. PMID: 25333972
19. The results show that NK cells and the NKG2D receptor play a role in control of lymphomas, and that selection of NKG2D-ligand (MULT1) loss mutants provides a mechanism for tumor escape. PMID: 26151313
20. these data support a novel role for NKG2D expression by CD8(+) T cells during allogeneic HSCT, which could be potentially therapeutically exploited to separate GVHD from GVT effects. PMID: 25788701
21. NKG2D and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity. PMID: 25634359
22. Viral infection of cultured cells increased RAE-1 expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition. PMID: 24898518
23. Activation through the NKG2D receptor leads to the differential activation of the NF-kappaB signaling pathway and potentially enhances the anti-tumor and anti-viral functions of effector CD8(+) T cells. PMID: 25089028
24. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-gamma in experimental dry eye. PMID: 25288568
25. Highly target-specific liver NKT cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 interaction to ameliorate liver fibrosis after IL-30 treatment. PMID: 25351459
26. a protective role of NKG2D-activated natural killer cells in coxsackievirus B3 myocarditis leading to an effective virus clearance PMID: 24797160
27. bystander memory CD8 T cells can participate in an unrelated immune response and induce immunopathology through an NKG2D dependent mechanism without providing increased protection. PMID: 24586170
28. Doxorubicin plus IL-12 induces NKG2D in CD8+T cells in vivo and boosts NKG2D+CD8+T-dependent antitumor immune surveillance PMID: 24565056
29. NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. PMID: 24610736
30. the induction of retinoic acid early transcript 1 (RAE1) ligands for NKG2D by the DDR relies on a STING-dependent DNA sensor pathway involving the effector molecules TBK1 and IRF3. PMID: 24590060
31. Cigarette smoke - induced airway injury stimulates toll-like receptor signaling by endogenous nucleic acids leading to elevated NKG2D ligand expression. PMID: 24130907
32. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice. PMID: 24708417
33. The absence of NKG2D signaling in natural killer cells significantly improves neural progenitor cell-derived neuron survival and differentiation. PMID: 23733329
34. studies established a pivotal role for NK-cell NKG2D and granzyme B in the pathogenesis of house dust mite-allergic lung disease, and identified novel therapeutic targets for the prevention and treatment of asthma. PMID: 24290277
35. NKG2D can function as a coactivating stress receptor that directly triggers cytotoxicity in dendritic epidermal T cells. PMID: 23962808
36. The severity of experimental autoimmune encephalitis was decreased in NKG2D-deficient mice. PMID: 24211717
37. NKG2D enhances IL-15-mediated Phosphatidylinositol 3-Kinase signaling of activated CD8 T cells, in a specific phase of memory cell commitment, after activation but before terminal differentiation. PMID: 23804716
38. NKp46 deficiency alone, or in combination with NKG2D deficiency, had no effect on frequency or function of NK cells PMID: 23649470
39. cytotoxic potential of NK cells against a wide spectrum of tumor subtypes could be markedly enhanced by expression of NKG2D-DAP10-CD3zeta receptors PMID: 23302231
40. The engagement of NKG2D by its ligand (Rae-1) elicits not only target cell lysis, but also natural killer cell fratricide. PMID: 23690625
41. The constitutive levels of NKG2D ligand expression on IECs are regulated by microbial signaling in the gut. PMID: 23136011
42. NKG2D is expressed by all natural killer (NK) cells but is not limited to NK cells, as it is also expressed by many T cells, including all activated CD8+ T cells in mice, subsets of gammadelta T cells, and subsets of NKT cells. PMID: 23298206
43. Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells. PMID: 23355740
44. Simultaneous knockdown of multiple ligands of NKG2D prevents natural killer cell-mediated fulminant hepatitis. PMID: 22806577
45. wound healing was delayed in mice lacking NKG2D PMID: 23166357
46. NKG2D-mediated, but not Fc receptor-mediated, recognition increases natural killer (NK) cell degranulation; only NKG2D engagement substantially enhances degranulation. PMID: 23183896
47. The expression of any of the murine ligands for the NK-cell activating receptor NKG2D results in a concomitant reduction in MHC class I expression. PMID: 22740149
48. IL-4-induced innate CD8 T cells do not express NKG2D (or CCL5). PMID: 22942430
49. NKG2D has no major role in the generation and expansion of memory CD8 T cells, but rather substantially enhances the cytolytic effector responses of reactivated memory T cells and thereby contributes to an efficacious tumor rejection. PMID: 21607945
50. Upregulation of NKG2D ligands by H-RasV12 increased sensitivity of cells to NK cell-mediated cytotoxicity PMID: 22798674

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KEGG: mmu:27007

STRING: 10090.ENSMUSP00000032252

UniGene: Mm.8217