Recombinant Mouse 5'-nucleotidase (Nt5e), partial (Active)

1. Deletion of CD73 in mice leads to aortic valve dysfunction similar to that induced by high-fat diet suggesting important role of this surface protein in maintaining heart valve integrity. PMID: 28192180
2. We establish that the mouse Nt5e minimal promoter transcriptional activity is negatively regulated by an Elf2-like Ets-related transcription factor in activated mouse liver myofibroblasts PMID: 28667437
3. CD73 derived adenosine production slows down migration of Langerin+ dendritic cells from skin to lymph nodes. This may be a crucial mechanism to avoid over boarding immune reactions against haptens. PMID: 28743609
4. Compared to adults, young WT mice failed to control S. pneumoniae infection after vaccination and this was associated with lower levels of CD73 on innate B cells. We hypothesized that pharmacological activation of A2a receptor may improve Pneumovax 23 immunization in young WT mice PMID: 29377929
5. The 5'-ectonucleotidase CD73 has a key role in regulating macrophage immune responses during efferocytosis by converting AMP released from apoptotic cells into adenosine to suppress multiple pro-inflammatory cytokines. PMID: 28060378
6. findings demonstrate the critical role of CD73 in the regulation of infection by the enteric pathogen Salmonella and implicate adenosine as an important host-derived factor that mediates host-microbe interaction PMID: 28717030
7. Data show that AMP deaminase 3 (Ampd3)-/-/5'-nucleotidase (CD73)-/- knockout mice are more sensitive to AMP-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type. PMID: 28746349
8. This study evaluated the role of CD73 in the accumulation and adhesion of pulmonary macrophages in response to thoracic irradiation. PMID: 28325757
9. Deletion of CD39 and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres. In vitro, unlike wild-type microglia, cd39-/- and cd73-/- microglial cells were less complex and did not respond to ATP with the transformation into a more ramified phenotype. PMID: 28376099
10. CD73 expression is regulated during experimental autoimmune encephalomyelitis, this enzyme is not absolutely required to either promote or limit Th17 cell expansion or experimental autoimmune encephalomyelitis severity. PMID: 28288184
11. High NT5E expression is associated with Radiation-Induced Lung Fibrosis. PMID: 26921334
12. Ablation of CD73 minimally effects in vivo thrombosis, but increased CD39 expression on hematopoietic-derived cells, especially monocytes, attenuates in vivo arterial thrombosis. PMID: 27417582
13. CD73 on T cells plays an important anti-inflammatory role in transverse aortic constriction-induced heart failure PMID: 28404626
14. In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell-based cancer vaccine PMID: 28349824
15. Data indicate that adenosine and CGS21680 upregulate CD39 and CD73 via E2F-1 and CREB. PMID: 27430240
16. CD73-siRNA-loaded ChLa NPs may be considered as a promising therapeutic tool for cancer therapy; however, further in vivo investigations are necessary PMID: 26733167
17. CD73/adenosine pathway involves the immunomodulatory function of mesenchymal stem cells in autoimmune responses. PMID: 26650818
18. CD73 facilitates AS by promoting migration, proliferation, and foam cell transformation of vascular smooth muscle cells and elevating serum lipid levels. PMID: 26506509
19. Low CD73 expression plays a role in melanoma progression. PMID: 26545615
20. These data reveal a novel function of CD73 ectonucleotidase in arresting CD8(+) T-cell differentiation and support the idea that CD73-driven adenosine production by Tc17 cells may promote stem cell-like properties in Tc17 cells. PMID: 26331349
21. gammadelta T cells expressed different CD73 amounts in different stages of experimental autoimmune uveitis. Low CD73 on gammadelta T cells enhanced Th17 response-promoting activity. Failure to express CD73 decreased enhancing and suppressive effects of gammadelta T cells. PMID: 26919582
22. Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration PMID: 26964090
23. CD73 activity from any host cell type is not required for the monocyte/macrophage polarization in the peritoneum towards a pro- or an anti-inflammatory phenotype in vivo PMID: 26258883
24. CD73 is not necessary for development of acute lung injury following influenza A virus infection. PMID: 26432867
25. The ecto-5'-nucleotidase derived extracellular formation of adenosine does not contribute substantially to adenosine's well known cardioprotective effect in early phase ischemic preconditioning. PMID: 26261991
26. CD73 expression was downregulated during acute infection with T. gondii, leading to impaired capacity to produce adenosine. PMID: 25389034
27. Expression of NPP1 and 5'-nucleotidase by valve interstitial cells promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway. PMID: 25644539
28. The CD73 deficiency significantly increased the levels of proinflammatory cytokines in mice. PMID: 25805696
29. our results support the view that CD73 fine-tunes antimycobacterial immune responses. PMID: 26150535
30. CD73 expression attenuates inflammation during murine Salmonellosis and impairs immunity, leading to increased bacterial colonization and prolonged infection. PMID: 24670982
31. CD73 is dispensable for normal CD8+ T-cell differentiation and function PMID: 25490556
32. The mouse model deficient in CD73, with other targeted mutant mice with vascular mineralization, attests to the presence of a complex pro-mineralization/anti-mineralization network that prevents ectopic tissue mineralization. PMID: 25486201
33. In the urothelium of animals with bladder cancer there was an increase in the expression of ecto-5'-nucleotidase. PMID: 24464643
34. Data show that CD73 (5' nucleotidase) deficiency resulted in greater disease incidence. PMID: 25681339
35. the absence of CD73-generated adenosine led to the increased susceptibility to Toxoplasma gondii infection in CD73 knockout mice. PMID: 25452548
36. CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature. PMID: 25402681
37. Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties. PMID: 25564652
38. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine. PMID: 24990899
39. CD73-dependent adenosine signaling is prominent in the mature GC and required for establishment of the long-lived PC compartment, thus identifying a novel role for CD73 in humoral immunity PMID: 24664100
40. that extracellular adenosine, generated in tandem by ecto-enzymes CD39 and CD73, promotes dermal fibrogenesis. PMID: 24266925
41. CD73-dependent production of extracellular adenosine and endothelial Adora2b signaling protects kidney during diabetic nephropathy. PMID: 24262796
42. Isoflurane causes TGF-beta1-dependent induction of renal tubular CD73 and adenosine generation to protect against renal ischemia and reperfusion injury. PMID: 23423261
43. identify CD73 as a TCR ligand-induced cell surface protein that distinguishes gammadeltaTCR-expressing CD4(-)CD8(-) progenitors that have committed to the gammadelta fate from those that have not yet done so PMID: 24493796
44. CD73 mRNA levels were also dramatically decreased in human liver biopsies from hepatitis C and nonalcoholic fatty liver disease patients PMID: 23729294
45. Data indicate that CD73 promoted metastasis through the activation of both A2A and A2B receptors. PMID: 23964122
46. Our data provide evidence for a role of CD73 in the regulation of learning and memory and psychomotor coordination PMID: 23274765
47. findings demonstrate that CD73-expressing exosomes produced by Treg cells following activation contribute to their suppressive activity through the production of adenosine PMID: 23749427
48. Our novel findings suggest an important immune-regulatory role of CD73 in regulation of diabetes development PMID: 23956420
49. NT5E (and prostatic acid phosphatase) are the main AMP ectonucleotidases in somatosensory neurons. PMID: 23825434
50. CD73 is upregulated in immune cells after ischemia/reperfusion in the myocardium. PMID: 23720442

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KEGG: mmu:23959

STRING: 10090.ENSMUSP00000034992

UniGene: Mm.244235