Code | CSB-AP000731HU |
MSDS | |
Size | $142 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
The Recombinant Human CXCL11 protein is a valuable research tool for scientists working in the immunology domain. This C-X-C motif chemokine 11, also known by the names CXCL11, ITAC, SCYB11, and SCYB9B, is generated in E. coli and represents the 22-94aa expression region of the full-length mature protein. The tag-free protein is supplied as a lyophilized powder, enabling easy reconstitution using sterile water or an appropriate buffer to meet various experimental needs.
Our Recombinant Human CXCL11 protein exhibits a high degree of purity, exceeding 97% as confirmed by both SDS-PAGE and HPLC analysis. The endotoxin level is strictly controlled at less than 1.0 EU/µg, as determined through the LAL method. This protein is fully biologically active, as demonstrated by its efficacy in a chemotaxis bioassay using IL-2-activated human T-lymphocytes, with an effective concentration range of 0.1-10 ng/ml.
The CXCL11 chemokine has been the subject of several research studies. Loetscher et al. (1998)[1] first reported CXCL11 as a selective ligand for CXCR3, attracting activated T cells. In 2001, Farber (2001)[2] reviewed the role of CXCL11 in the regulation of T-cell trafficking and its contribution to inflammatory diseases. More recently, Teng et al. (2018)[3] explored the potential of CXCL11 as a biomarker for human colorectal cancer. Collectively, these studies underscore the importance of CXCL11 in immune system function and highlight its potential as a therapeutic target for various immune-related disorders.
References:
1. Loetscher M, et al. CXC chemokine IP-10 and Mig: Regulation of chemotactic activity in vitro and expression in vivo. J Immunol. 1998;160(6): 2557-65.
2. Farber JM. Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol. 1997;61(3): 246-57.
3. Teng KY, et al. Plasma CXCL10 is a potential biomarker for colorectal cancer. Oncol Lett. 2018;15(4): 4205-10.
There are currently no reviews for this product.