Recombinant Human Fibroblast growth factor 19(FGF19),partial

In Stock
Code CSB-AP003911HU
Product Type Growth Factor
Size US$137
Uniprot No. O95750
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias Fibroblast growth factor 19; FGF-19; FGF19
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to bind Human FGF R3 in functional ELISA is less than 15 ug/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Signal Transduction
Source E.coli
Gene Names FGF19
Expression Region 27-216aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 23.5 kDa
Protein Description Partial
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Function Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Subcellular Location Secreted
Protein Families Heparin-binding growth factors family
Tissue Specificity Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Database Links

HGNC: 3675

OMIM: 603891

KEGG: hsa:9965

STRING: 9606.ENSP00000294312

UniGene: Hs.249200

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Ras signaling pathway
Rap1 signaling pathway

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