Code | CSB-RA546047A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:2000 |
Yielding the FGF19 recombinant monoclonal antibody involves the FGF19 monoclonal antibody harvest, FGF19 monoclonal antibody gene sequencing, FGF19 monoclonal antibody gene-carrying vector construction, and plasmid vector transfection and culture. The synthesized peptide derived from human FGF19 is used as the immunogen during the FGF19 monoclonal antibody production. The resulting FGF19 monoclonal antibody is subjected to affinity chromatography. Its specificity is tested in ELISA and WB applications.
FGF19 is a protein that plays a role in bile acid homeostasis and glucose metabolism. FGF19 is mainly produced in the ileum of the small intestine in response to the activation of the farnesoid X receptor (FXR), which is a nuclear receptor that senses the levels of bile acids in the intestine. FGF19 binds to and activates the FGFR4 in the liver, leading to the suppression of bile acid synthesis and the promotion of glycogen and protein synthesis. FGF19 has been studied as a potential therapeutic target for metabolic diseases, such as type 2 diabetes and non-alcoholic fatty liver disease.
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