Recombinant Human interleukin-16 protein(IL16) (Active)

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Code CSB-AP001631HU
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of >1.0x109 IU/mg.
Target Names IL16
Uniprot No. Q14005
Research Area Immunology
Alternative Names HGNC:5980; HsT19289; IL-16; IL16; IL16_HUMAN; Interleukin 16 precursor; Interleukin-16; LCF; Lymphocyte chemoattractant factor; Neuronal interleukin 16; NIL16; prIL 16; PrIL16 ; Prointerleukin 16
Species Homo sapiens (Human)
Source E.coli
Expression Region 1203-1332aa
Mol. Weight 13.4 kDa
Protein Length Partial
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION
Gene References into Functions
  1. rs11556218 is associated with endometriosis in Greek women, probably by resulting in the aberrant expression of IL16 PMID: 29328375
  2. There was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with gestational diabetes mellitus, however, there was no significant difference in the distribution of alleles. PMID: 28580570
  3. Serum IL-6, serum YKL-40, and plasma VEGF were significantly correlated with disease activity at baseline in early rheumatoid arthritis. PMID: 29336711
  4. serum IL-16 level may not only serve as a useful diagnostic biomarker for patients with GC, but also may predict cancer recurrence and patient prognosis. PMID: 28990054
  5. Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk. PMID: 27703190
  6. Results suggest that IL16 genotype predict higher risk of death and progression, respectively, in NSCLC patients PMID: 28807247
  7. rs11556218 T/G genotype associated with increased risk for development of osteoporosis in Chinese postmenopausal women PMID: 27984748
  8. Data indicate an association between interleukin-16 (IL-16) rs4072111 and rs1131445 with progression to the severe stages (III-IV) of endometriosis. PMID: 27484651
  9. Long-term exposure to tobacco smoke does not markedly alter extracellular concentrations of IL-16 protein in blood. However, it does decrease the intracellular IL-16 concentrations in blood NK cells. PMID: 27695312
  10. data revealed an association between circulating IL-16 and severity of psoriasis which indicates that this cytokine could serve as a potential marker of disease activity. However, further investigations are required PMID: 27788245
  11. Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 PMID: 27231345
  12. No significant differences were observed in rs11556218 genotype frequencies between the study groups. In conclusion, the results of our study reveal an association between the IL-16 rs4778889 polymorphism and heightened risk of renal cell cancer . PMID: 27323152
  13. We found that the rs1131445 T/C and rs4072111 T/C variants of IL-16 were significantly associated with increased risk of gastric cancer in Iranian population. PMID: 26346169
  14. the results of our study suggested an association between the IL-16 rs4778889 polymorphism and an elevated risk of renal cell carcinoma PMID: 26823871
  15. We observed highly significant reductions in the concentration of circulating interleukin (IL)-16, IL-7, and Vascular Endothelial Growth Factor A (VEGF-A) in encephalomyelitis/chronic fatigue syndrome patients. PMID: 26615570
  16. IL-16 rs1131445 C/T polymorphism is related to the susceptibility to cancer in Asians (meta-analysis) PMID: 26842762
  17. The IL16 rs4072111 polymorphism may be associated with susceptibility to AD and the T allele may have a protective role in the progression of AD in an Iranian population. PMID: 26386715
  18. intrathyroidal production of IL-14 and IL-16 associated with the pathogenesis of autoimmune thyroid disease PMID: 25940130
  19. the lack of a relationship between genotype and serum levels of IL-16 seems to suggest a more complex regulation of this cytokine at the post-translational level and/or the interplay with other cytokines. PMID: 26154181
  20. The results suggested that the variants in IL-16 gene rs11556218 site were associated with a decreased knee osteoarthritis risk after adjusting for age, sex, BMI, and smoking and drinking status. PMID: 25954818
  21. Data suggest that thymic stromal lymphopoietin (TSLP) and interleukin-16 (IL-16), expressed at early stages of disease, function to recruit malignant T cells to the skin. PMID: 24794807
  22. The production of IL-16 contributed to lung damage as neutralization of IL-16 enhanced S. aureus clearance and resulted in diminished lung pathology in S. aureus pneumonia. PMID: 24736233
  23. The findings suggest that the IL-16 rs 11556218 polymorphism may be used as a susceptibility marker for glioma. PMID: 25166752
  24. IL-16 rs11556218 T/G was associated with a significant increased risk of cancer. PMID: 24969906
  25. The rs11556218 T/G polymorphism of the IL-16 gene was significantly associated with elevated cancer risk in Asian populations. [meta-analysis] PMID: 24328527
  26. IL16 polymorphisms may play a role in the pathophysiology of alopecia areata or in the expression of phenotypes in Koreans. PMID: 24320753
  27. IL-16 rs4778889 T/C polymorphism is not associated with cancer. PMID: 24568499
  28. The IL-16 SNP rs8028364 was found to be associated with Graves' disease(GD) when compared with the control subjects. PMID: 24694201
  29. An association between decreased plasma IL-16 and emphysema susceptibility. PMID: 24138069
  30. Rs4778889 CC and rs11556218 GG genotype was significantly associated with 1.97 and 1.84-fold increased risk of non-cardia gastric cancer. PMID: 24175812
  31. the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population PMID: 24288444
  32. This study showed that tissue expression and serum levels of IL-16 increase in association with malignant ovarian tumor development and progression. PMID: 24380743
  33. IL-16 plays an important role in the proliferation and apoptosis of MT-4 cells PMID: 24200060
  34. Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PMID: 23894370
  35. The IL-16 SNPs rs8034928 and rs11556218 are associated with the coronary artery disease risk in the Chinese population. PMID: 23881440
  36. It is feasible to predict preterm birth by measuring the amniotic fluid levels of IL-16 especially for the pregnant women requiring genetic amniocentesis during early second trimester. PMID: 23020666
  37. Authors identified three independent loci within IL16 that were associated with prostate cancer risk. SNP expression quantitative trait loci analyses revealed that rs7175701 is predicted to influence the expression of IL16 and other cancer-related genes. PMID: 22923025
  38. study identified IL-16 as a critical tristetraprolin-regulated chemotactic factor that contributes to monocytes/macrophages migration PMID: 23241166
  39. a significant relationship exists between the miRNA-binding site polymorphism of the IL-16 gene and colorectal cancer risk in the Iranian population PMID: 22939228
  40. IL-16 was strongly overexpressed in the bone marrow of myeloma patients compared with healthy donors. IL-16 is an important growth-promoting factor in multiple myeloma. PMID: 22745469
  41. IL-16 rs11556218 G/T polymorphism is significantly associated with the risk of coronary artery disease in the Chinese Han population. PMID: 21703255
  42. Data show that IL16 single nucleotide polymorphisms are associated with chronic hepatitis B virus infection and hepatocellular carcinoma. PMID: 22019522
  43. Serum IL-16 levels of atopic dermatitis patients correlate to some extent with sensitization. PMID: 21447961
  44. Our results demonstrate that loss of intracellular IL-16 in peripheral blood T cells corresponds to lymphoma stage in Sezary Syndrome patients and orrelates with loss of surface CD26. PMID: 20878214
  45. TcdA and TcdB downregulate IL-16 gene expression via inhibition of Rho GTPases.(TcdA and TcdB from C. difficile strain VPI 10463) PMID: 21267712
  46. The TG/GG genotypes of rs11556218 T/G were associated with a significantly increased risk of coronary artery disease as compared with the TT genotype. PMID: 21214401
  47. Ability of IL-16 homolog from leech Hirudo medicinalis to recruit microglial cells to sites of nervous system injury suggests its in the crosstalk between neurons and microglia in the leech central nervous system repair. PMID: 20578037
  48. Tobacco smoke depletes preformed intracellular IL-16 protein, inhibits its de novo synthesis, and distorts key cellular functions in human CD8(+) cells. PMID: 21036918
  49. the rs4778889 T/C polymorphism of the IL-16 gene may be associated with risk of endometriosis PMID: 20662556
  50. IL-16 -295 T>C polymorphism is significantly associated with a higher risk of developing RCC in Chinese population. PMID: 20529140
  51. Treatment with neutralizing anti-IL-16 antibody successfully reversed paralysis and ameliorated relapsing experimental autoimmune encephalomyelitis (EAE). Relevance for the development of new therapies for relapsing EAE and potentially MS. PMID: 15682385
  52. Suggest that caspase-3 mediated production of IL-16 by infiltrating CD4+ T cells, contributes to ongoing neuroinflammation by chemoattraction of additional waves of CD4+ T cells in relapsing experimental autoimmune encephalomyelitis (EAE). PMID: 16271292
  53. Correlations between increased levels of secreted IL-16, CD4+ Th1 cell inflammation, and phosphorylation of axonal cytoskeleton in Multiple sclerosis (MS) lesions. Possible role for IL-16 in regulation of inflammation and axonal cytoskeleton in MS. PMID: 6729885
  54. The intensity of IL-16 and CXCR3 expression were correlated with the index of clinical and pulmonary function in COPD. PMID: 20079227
  55. Increased levels of circulating IL-16 and apoptosis markers are related to the activity of Whipple's disease. PMID: 17551575
  56. A possible prognostic role of IL-16 in lymphoid malignancies. PMID: 17577790
  57. IL-16 released from epidermal Langerhans cells after allergen-mediated activation through Fc epsilon RI may link IgE-driven and cellular inflammatory responses in diseases such as atopic dermatitis. PMID: 11714796
  58. IL-16 enhances c-kit ligand-mediated expression of tryptase and chymase in mast cells and basophils developed from cord blood and peripheral blood progenitors, is a chemotactic factor for these cells, and inhibits their vulnerability to HIV-1 infection. PMID: 11937573
  59. Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus. PMID: 11999883
  60. serum level of (IL)-16 was significantly higher in stage III multiple myeloma patients than in healthy controls. The decrease of CD4(+) T cells in MM may be mediated by activation of CD8(+) T cells derived cytokine IL-16. PMID: 12191564
  61. The bipartite nuclear localization sequence (NLS) of pro-IL-16 is part of a dual phosphorylation-regulated CcN motif consisting of a protein kinase CK2 substrate site, a cdc2 kinase substrate site, and an NLS. PMID: 12450396
  62. binds to Tax in HTLV-1 infected T cells PMID: 12620798
  63. identified three closely related myosin phosphatase targeting subunits, MYPT1, MYPT2, and MBS85, as binding partners of the IL-16 precursor proteins PMID: 12923170
  64. IL16 genotype was overrepresented among polysensitized individuals (7.0% vs 1.0% in the control group; odds ratio, 7.68; 95% CI, 1.59-48.12) with allergic contact dermatitis to para-substituted aryl compounds PMID: 14657881
  65. the cytokine IL-16 plays a role in the disease process underlying rheumatoid arthritis and joint destruction. PMID: 14705216
  66. Nuclear IL-16 precursor is identified as a novel regulator of S-phase kinase-associated protein-2 (Skp2) expression and cyclin-dependent kinase inhibitor 1B (p27KIP1) levels, with a role in T cell proliferation. PMID: 14734747
  67. Patients with a high level of IL-16 (>430 pg/ml) in multiple myeloma displayed an inferior survival time in comparison to those with lower levels of IL-16. PMID: 14755377
  68. recruitment of IL-16+ T cells and microglia/macrophages may represent an innate response to HIV-1 infection in the central nervous system that counterbalances viral stimulatory factors PMID: 15175077
  69. IL-16 is constitutively present in peripheral blood monocytes; spontaneous caspase-3 activation (apoptosis) was paralleled by the loss of intracellular IL-16; stimulation with LPS inhibited caspase-3 activation and inhibited the release of IL-16. PMID: 15187155
  70. interleukin-16 and its precursor have roles in T lymphocyte activation and growth [review] PMID: 15253385
  71. Increased IL-16 levels are associated with hemophagocytic lymphohistiocytosis PMID: 15342983
  72. IL-16 is a potent promoter of eosinophil migration through the extracellular matrix components, an effect that is initiated via CD4 and mediated via the release of CCR3 ligand chemokines. PMID: 15383572
  73. IL16 may play an important role in the development of alopecia areata PMID: 15619436
  74. IL-16 in peritoneal fluid may play a role in the pathogenesis of endometriosis by initiating or sustaining inflammatory responses in the peritoneal cavity PMID: 15820794
  75. IL-12 and IL-16 may be related to the pathogenesis of periodontal disease, but within the periodontitis sites, IL-16 may be related to disease severity in alcohol drinkers/smokers PMID: 15886011
  76. IL-16 activates a PI3K/inositol trisphosphate-dependent signaling pathway in mast cells; CD9 is essential for the IL-16-mediated chemotaxis and activation, acting as an IL-16 receptor in HMC-1, a mast cell line that lacks CD4 PMID: 16144798
  77. IL-16, which is up-regulated in macrophages (Mphi), enables Tropheryma whipplei to replicate in monocytes and increases bacterial replication in Mphi; IL-16 down-modulates expression of thioredoxin and up-regulates that of IL-16 and proapoptotic genes PMID: 16177102
  78. determined the effects of IL-16 interaction with CD4 on CXCR3-induced migration PMID: 16455991
  79. IL-16 immunoreactivity is a putative marker of a monocytic subset in human gliomas in vivo and may be a novel factor in the regulation of the local inflammatory milieu and tumor progression. PMID: 17221335
  80. an elevation of serum IL16 appears in early trimester of pregnancy of women who later develop preeclampsia, suggesting IL16 plays a role in the pathogenesis of preeclampsia PMID: 17537415
  81. pro-IL-16 forms a complex with GABPbeta1 and HDAC3 in suppressing the transcription of Skp2. PMID: 18097041
  82. Susceptibility genes CPNE3, IL16 and CDH13 with moderate effects associated with susceptibility to prostate cancer. PMID: 18264096
  83. IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population. PMID: 18394967
  84. IL-17 and TLR2 ligands stimulate the production of IL-16 by rheumatoid arthritis fibroblast-like synoviocytes PMID: 18446062
  85. IL-16 levels are significantly higher in severe preeclampsia (PE) than in mild PE and normal pregnant controls, indicating that increased IL-16 levels in PE are associated with the severity of the disease. PMID: 18768901
  86. IL-16 polymorphisms may contribute to CRC and GC susceptibility. PMID: 19073878
  87. Generation of bleomycin-induced lung fibrosis is independent of IL-16 PMID: 19232499
  88. The IL-16 gene polymorphisms may be associated with the risk of systemic lupus erythematosus. PMID: 19298795
  89. decreased levels following alpine mountain climate therapy in patients with allergic diseases and chronic obstructive pulmonary disease PMID: 19476022
  90. an association between IL-16 gene polymorphisms and the risk of nasopharyngeal carcinoma PMID: 19758567

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Subcellular Location Interleukin-16: Secreted, SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, Nucleus
Tissue Specificity Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
Database Links

HGNC: 5980

OMIM: 603035

KEGG: hsa:3603

STRING: 9606.ENSP00000302935

UniGene: Hs.459095

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