Recombinant Mouse Interleukin-36 alpha protein(Il36a) (Active)

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Code CSB-AP003431MO
Product Type Interleukin
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Uniprot No. Q9JLA2
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered PBS, 1 mM DTT, 3 % trehalose ,lyophilized
Alias FIL1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, Interleukin-1 homolog 1
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x104 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source E.coli
Gene Names Il36a
Expression Region 8-160aa
Tag Info Tag-Free
Mol. Weight 17.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 10744718; 11466363; 16141072; 20101239; 21860022; 21965679; 21881584; 23029241; 24829417
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Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in proinflammatory effects in the lung
Subcellular Location Secreted
Protein Families IL-1 family
Tissue Specificity Highly expressed in embryonic tissue and in tissues containing epithelial cells. Elevated expression levels are detected in chronic kidney disease; expressed inepithelia from the distal convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in
Database Links

KEGG: mmu:54448

STRING: 10090.ENSMUSP00000028361

UniGene: Mm.133095

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