TTR Monoclonal Antibody

Code CSB-MA831325
Size US$167
  • Immunohistochemical analysis of paraffin-embedded Human Liver Carcinoma Tissue using TTR Mouse mAb diluted at 1:200

  • Immunohistochemical analysis of paraffin-embedded Human Thyroid Tissue using TTR Mouse mAb diluted at 1:200

  • Western blot analysis of Human Serum using TTR Mouse mAb diluted at 1:2000

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Product Details

Uniprot No. P02766
Alternative Names Amyloid polyneuropathy antibody; Amyloidosis I antibody; ATTR antibody; Carpal tunnel syndrome 1 antibody; CTS antibody; CTS1 antibody; Dysprealbuminemic euthyroidal hyperthyroxinemia antibody; Dystransthyretinemic hyperthyroxinemia antibody; Epididymis luminal protein 111 antibody; HEL111 antibody; HsT2651 antibody; PALB antibody; Prealbumin amyloidosis type I antibody; Prealbumin antibody; Prealbumin Thyroxine-binding antibody; Senile systemic amyloidosis antibody; TBPA antibody; Thyroxine binding prealbumin antibody; Transthyretin antibody; TTHY_HUMAN antibody; TTR antibody; TTR protein antibody
Raised in Mouse
Species Reactivity Human
Immunogen Recombinant Protein
Conjugate Non-conjugated
Purification Method The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:50-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Gene References into Functions
  1. familial amyloid polyneuropathy (FAP) carriers and patients are in an inflammatory state, with the presence of mutated TTR being a trigger of inflammation, especially in FAP carriers. PMID: 28484271
  2. In this review, we discussed the role of Ttr in CNS and its possible role in the neuroprotection mechanism of Semax. PMID: 30383932
  3. serum prealbumin, and its changes were independent predictors of worse prognosis in acute kidney injury (AKI), and could be potential surrogates to better predict 90-day mortality. PMID: 28145481
  4. T139R mutation may expose the buried regions of TTR protein which help in the self association and the increase in the stability may help in the TTR deposition. Structural analysis indicated that F and H strands of TTR are more prone to aggregation. Thus, T139R mutation might cause these residues to be aggregation prone and change in folding rate and validated TTR monomer in diseased cases by Western blot analysis. PMID: 29564986
  5. High TTR expression is associated with hypertriglyceridemia. PMID: 29747616
  6. Our study characterizes G101S TTR as a stable and N-glycosylable TTR, which may be linked to its non-amyloidogenic characteristic. G101S TTR had slower rate of tetramer dissociation and lower propensity for amyloid fibril formation, especially at mild low pH (4.2 and 4.5), and was likely to have strong hydrophobic interaction among TTR monomers, suggesting relatively higher stability of G101S TTR compared with WT TTR. PMID: 29607936
  7. studies of a unique duplication mutation explain its diflunisal-resistant nature, identify misfolding pathways for amyloidogenic TTR variants, and provide therapeutic targets to inhibit amyloid fibril formation by variant TTR. PMID: 29941560
  8. At physiological temperature, the monomeric intermediate formed by wild-type TTR under mildly acidic conditions rapidly aggregates into species that are invisible to NMR, leading to loss of the NMR signal at the same rate as the turbidity increase. PMID: 29915031
  9. We report here three non-related Hungarian cases of transthyretin familial amyloid polyneuropathy with non-Val30Met mutations (His88Arg in two cases, Phe33Leu in one case) PMID: 29465889
  10. A novel amyloidogenic TTR mutation was found in a Dutch family PMID: 28460244
  11. Patients with ATTRV30M amyloidosis in non-endemic areas and patients with non-V30M ATTR amyloidosis occurred more frequently than previously believed, and their clinical manifestations were diverse. PMID: 29177547
  12. Results indicate that TTR stability is important for its recently described functions in assisting Abeta transport at the BBB and at the liver and also in regulating LRP1 levels and activity. TTR stabilization can serve as an avenue to increase both Abeta elimination and LRP1 levels, which in turn will further participate in Abeta clearance. PMID: 28570028
  13. Findings are the first to show that TTR deposition increases disease severity in the murine DMM and aging model of OA. PMID: 28941045
  14. This study demonstrated that both cardiac and peripheral vasomotor autonomic dysfunctions were prevalent in late-onset FAP ATTR Val30Met patients from non-endemic areas, even in those without orthostatic intolerance. PMID: 28983659
  15. could potentially downregulate the TTR promoter activity; c.200+4A>G might influence the constitutive splicing of TTR mRNA PMID: 27562180
  16. Systematic computational prioritization identified a missense mutation c.G148T in TTR gene which results in a p.V50L substitution known to cause transthyretin-related familial amyloid polyneuropathy. PMID: 27212199
  17. This stuidy found two mutations, Thr49Ala(p.Thr69Ala) and Tyr116Ser(p.Tyr136 Ser), were detected in Chinese familial amyloid polyneuropathy patients for the first time. PMID: 27859927
  18. The results suggest an association between presumed nonamyloidogenic mutations in the TTR gene and the development of autonomic and small fiber neuropathy. PMID: 28556268
  19. Clinical, electrophysiological, histopathological, and genetic characteristics of 17 patients from Turkey (5 female, 13 male) from nine families with polyneuropathy and mutations in TTR were evaluated. Sequence analysis of the TTR gene revealed five mutations (Val30Met, Glu89Gln, Gly53Glu, Glu54Gly and Gly47Glu). Study suggests that a cohort of patients from Turkey with TTR-FAP exhibits clinical and genetic heterogeneity. PMID: 27238058
  20. It is one of the major Abeta-binding proteins acting as a neuroprotector in AD. In addition, TTR cleaves Abeta peptide in vitro. PMID: 28780366
  21. Stroke patients with lower transthyretin levels had poorer Functional Independence Measure outcomes and tended not to be discharged to their own homes. PMID: 28314625
  22. TTR expression varied across human populations PMID: 28335735
  23. Cell-based experiments showed that overexpression of TTR could improve HK-2 cell viability and inhibit apoptosis. PMID: 29040977
  24. These results clarify a negligible degree of unfolding of beta-strand C in the formation of the amyloidogenic state and establish the concept that TTR is a highly plastic protein able to populate at least three distinct conformational states. PMID: 28478513
  25. A strong phenotypic heterogeneity was demonstrated across coding mutations causing TTR amyloidosis. Non-coding variants affect TTR expression and, consequently, phenotypic presentation in carriers of amyloidogenic mutations. PMID: 28635949
  26. Serum prealbumin was significantly lower in patients with versus those without post-stroke depression, and was a significant predictor of post-stroke depression after adjusting for confounding risk factors. PMID: 27693925
  27. TTR induced apoptosis of retinal microvascular endothelial cells in an environment that simulated hypoxia. PMID: 28950253
  28. Data suggest that transthyretin exhibits site-specific solvation of the indole ring of tryptophans W41 and W79; these studies involved incorporation of tryptophan labeled with fluorine at 5 or 6 positions (5-fluorotryptophan/5FW or 6-fluorotryptophan/6FW) into recombinant TTR; replacement of fluorine at 5-position of a tryptophan with one at adjacent 6-position emphasizes delicate balance of stability in TTR tetramer. PMID: 28920433
  29. This study shows that highly destabilized, aggregation-prone TTR variants are secreted as both native tetramers and non-native conformations that accumulate as high-molecular-weight oligomers. PMID: 27720586
  30. The role of transthyretin in normal pregnancy is reviewed. PMID: 27650990
  31. the role of H88 and the hydrogen bond network in the stability of TTR PMID: 28563699
  32. we identify a somatic mosaicism, in several subjects affected by familial amyloidotic polyneuropathy, involving the dominant c.325G>C mutation of the TTR gene PMID: 28508289
  33. The role of Transthyretin in the regulation of Ubc9 SUMOylation PMID: 27501389
  34. Gene sequencing revealed a phenylalanine-->isoleucine mutation in the 33rd position of exon 2 of TTR in 1 patient of 1 pedigree, confirming the diagnosis of FAP. Two patients subsequently were found to have sensorimotor autonomic neuropathy, whereas 2 others had subclinical autonomic dysfunction. PMID: 28412068
  35. TTR V30M aggregates and autophagy impairment are associated with Transthyretin amyloidoses . PMID: 27382986
  36. In Afro-Caribbean patients living in London, ATTR V122I is an underappreciated cause of heart failure, and cardiomyopathy is often misattributed to hypertension. PMID: 27618855
  37. Val122Ile is the most common transthyretin mutation, and neurologic phenotypic expression differs between wild-type disease and Val122Ile, but survival from enrollment in THAOS does not. PMID: 27386769
  38. In the bound state, the Hsp90 dimer predominantly populates an open conformation, and transthyretin retains its globular structure. PMID: 28218749
  39. findings show that, at physiologically-relevant protein concentrations, the refolding pathways of WT-TTR and amyloidogenic variant V30M-TTR follow a common mechanism observed among other tetrameric proteins; although sharing the same kinetic mechanism, V30M-TTR refolds at a slower rate than WT-TTR, a feature that may favor the formation of transient species leading to kinetic partition into amyloidogenic pathways PMID: 27589730
  40. This study reports the discovery of a TTR mutant, N98A, that was more effective at inhibiting ABETA aggregation than wild-type (WT) TTR, although N98A and WT bound ABETA equally. PMID: 27099354
  41. Results provide evidence that TTR acts as a carrier of Abeta at the blood-brain-barrier and liver, using LRP1. PMID: 26837706
  42. The study reports a Japanese family with hereditary ATTR amyloidosis with the TTR G47R mutation in which one family member developed the disease at the age of 13. PMID: 27206384
  43. a point mutation was identified in the upstream regulatory region of the TTR gene in a Han Chinese family with familial vitreous amyloidosis. PMID: 27051017
  44. Data indicte that the use of polyethylene glycol (PEG) to crystallize transthyretin (TTR complexes have resulted in a new trigonal polymorph with two tetramers in the asymmetric unit. PMID: 26796656
  45. A novel autosomally inherited Lys90Glu mutation in the TTR gene in a family with vitreous amyloidosis and carpal tunnel syndrome. PMID: 26828956
  46. illustrates the diversity of symptoms encountered in homozygote ATTR V30M patients PMID: 26587769
  47. Caucasian patients with the Val142Ile pathogenic variant have phenotypic manifestations similar to African-Americans PMID: 26428663
  48. Data suggest that well-structured AB loop regions of TTR in native/homotetrameric/stable state become dissociated/disordered/unfolded at low pH; during refolding, structural perturbations in AB loop appear and facilitate misfolding and amyloid formation. PMID: 26998642
  49. Eight water molecules stabilize the dimeric structure through an extensive hydrogen-bonding network. PMID: 26527142
  50. Study elucidated alterations in TTR, APP and the global gene expression profile in the frontal cortex between idiopathic normal pressure hydrocephalus patients and nondemented control brain PMID: 26444765
  51. Quantitative analysis of post-translational modifications in human serum transthyretin associated with familial amyloidotic polyneuropathy by targeted LC-MS and intact protein MS. PMID: 25910794
  52. Large differences in survival were observed in hereditary transthyretin amyloidosis patients with TTR mutations other than Val30Met. PMID: 26656838
  53. Ile107Val and LateMet30 TTR mutations are associated with the most debilitating and severe familial amyloid polyneuropathy, with rapid onset of tetraparesis and shorter median survival. PMID: 26369527
  54. study reports a novel TTR variant(TTR Asp38Tyr mutation) in 2 Brazilian sisters who developed a late onset neuropathy; new mutation calls attention to the diversity found in TTR familial amyloid polyneuropathy PMID: 25857202
  55. The structures of TTR in complex with three natural polyphenols (pterostilbene, quercetin and apigenin) have been determined. PMID: 26249340
  56. The conserved water mediated recognition dynamics of the different functional sites may provide some rational clues towards the understanding of the activity and mechanism of hTTR. PMID: 25372987
  57. beta-strands F and H as necessary for TTR aggregation. PMID: 26459562
  58. Given the high conservation of TTR structure, function and tissue specificity and timing of gene expression, this implies that TTR has a fundamental role, during development and in the adult. PMID: 25737004
  59. the Swedish TTRHis88Arg patients all have a common Swedish founder. Cardiomyopathy with heart failure, as well as carpal tunnel syndrome and spinal stenosis were early signs of disease; but peripheral neuropathy was present in one patient before symptoms of cardiomyopathy so the phenotypical presentation of this mutation is variable. PMID: 25721874
  60. Open-label clinical trial of tafamidis in patients with non-Val30Met and non-Val122Ile hereditary transthyretin amyloidosis shows no change in cardiac findings. PMID: 25743445
  61. The interaction of the amyloidogenic V122I TTR with human cardiomyocytes is distinct from that of a non-amyloidogenic TTR variant and is characterized by its retention at the cell membrane, where it initiates the cytotoxic cascade. PMID: 25395306
  62. The results suggest that amyloid substance was present in the blood of familial amyloidotic polyneuropathy patients with the ATTR Val30Met mutation. PMID: 25550818
  63. TTR, which is located predominantly at the cartilage surfaces, was detected in all osteoarthritis cartilage samples and in a majority of aged normal cartilage samples, but not in normal cartilage samples from young donors. PMID: 25940564
  64. In critically ill trauma patients, low serum TTR level is associated with poorer clinical outcomes. PMID: 26003908
  65. Case Report: characterization of untyped cardiac amyloidosis by mass spectrometry in a patient with Gly6Ser transthyretin polymorphism in fatal cardiogenic shock. PMID: 24070596
  66. Tafamidis treatment effectively achieved and maintained TTR stabilization in transthyretin amyloid cardiomyopathy. PMID: 25872787
  67. The review show the relevance of TTR in normal state and in disease especially in several neuropathologies where its level varies. Also, its neuroprotective role in schemia and Alzheimer's disease was also dicussed. PMID: 25372741
  68. a TTR Gly-54 point mutation in the 2nd exon is a novel mutation in vitreous amyloidosis in Chinese PMID: 22187309
  69. Study investigated the phenotypic and genotypic spectra of hereditary ATTR in Korea; Of 12 genetic tests performed, seven were positive for TTR mutations. D58A (c.173A>C) was the most common mutation in this study (57%, 4/7). PMID: 25644864
  70. Diflunisal might be effective especially for autonomic dysfunction in late-onset FAP with a TTR Val30Met mutation. PMID: 25060417
  71. The link between TTR secondary structures and mutation impact, and the relationship between mutations and amyloidogenic propensity have been presented. PMID: 24779883
  72. Using circular dichroism spectroscopy, the study determined that CLU preferentially stabilizes monomeric TTR and generates increasingly stable conformations under acid stress. PMID: 25478940
  73. findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of Liver Ttransplantation PMID: 25091367
  74. Genetic variation of the transthyretin gene is associated with wild-type transthyretin amyloidosis. PMID: 25367359
  75. Transthyretin, one of the major plasma proteins, has a number of posttranslational modifications and mutations, some of which are associated with the development of severe diseases, for instance, familial amyloid neuropathy and Alzheimer's disease PMID: 25509863
  76. Lys-35 is as a gatekeeper residue in transthyretin preventing the protein from aggregation. PMID: 25086037
  77. We did not detect a significant difference in mortality between V122I TTR allele carriers and noncarriers, a finding that contrasts with prior observations; however, the risk of heart failure was increased among carriers. PMID: 25551524
  78. Data suggest that TTR and TTR mutants (seen in subjects with senile systemic amyloidosis) have similar amyloidogenic potential and similar thermodynamic/kinetic stabilities; this study emphasizes protein stability under physiological conditions. PMID: 25245430
  79. MPO/H2O2 system using two-dimensional gel electrophoresis and TTR Western blotting. This observation revealed that the TTR amyloid deposits and serum TTR were oxidized by the MPO/H2O2/NO(-) system. PMID: 24781992
  80. These findings strongly support further investigations on the diagnostic utility of TTR aggregate specific monoclonal antibodies for patients with TTR amyloidoses. PMID: 24164623
  81. TTR Ile107Met mutation is associated with vitreous amyloidosis and familial amyloid polyneuropathy. PMID: 24480837
  82. TTR V30M carrier frequency in a northern Swedish population. PMID: 24555660
  83. The EPO concentration in the aqueous humor of familial amyloidotic polyneuropathy (FAP) and non-FAP patients, with and without glaucoma, was evaluated. PMID: 25018619
  84. We now show that the amyloid beta-peptide clearance protein transthyretin is also epigenetically up-regulated by amyloid precursor protein intracellular domain PMID: 24528201
  85. Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-kappa. PMID: 24390749
  86. once monomers of transthyretin are released from the tetramer, equilibrium is established between a set of conformational states possessing different degrees of disorder PMID: 24945718
  87. This study is the largest homozygous TTR gene V122I polymorphism cohort reported and demonstrates association with earlier age at onset than for heterozygotes. PMID: 24184229
  88. Cardiac amyloid formation of wild-type transthyretin is affected by age and sex differences in familial amyloidotic polyneuropathy (FAP). PMID: 24182678
  89. The natural history of Ser50Arg, Ser52Pro and Gly47Ala TTR mutations is similar to the Val30Met mutation described in familial amyloidosis polyneuropathy in endemic areas. PMID: 24053266
  90. Vitreous opacity is very common in patients with the TTR Gly83Arg mutation; other clinical characteristics associated with the mutation include polyneuropathy and cardiac amyloidosis. PMID: 24113303
  91. The current data suggest one possible mechanism that can account for the increased production of TTR as a potential protective molecule during the course of alzheimer disease. PMID: 24849358
  92. Immunoglobulin amyloid light-chain (AL)-related cardiac amyloidosis (CA) has a worse prognosis than either wild-type (ATTRwt) or mutant (ATTRm) transthyretin (TTR) CA. PMID: 24563469
  93. we have identified a potential monitoring biomarker TTR for Kawasaki disease. PMID: 24690176
  94. The studies reveal a novel antibody property, the innate ability of IgMs to selectively degrade and dissolve toxic misTTR species as a first line immune function. PMID: 24648510
  95. Measurement of prealbumin levels allows a more accurate prediction of mortality in elderly chronic heart failure patients. PMID: 23623341
  96. transthyretin is dysregulated in cases of intrauterine growth restriction and severe early onset preeclampsia; interestingly, TTR expression is not affected in cases with HELLP syndrome that reveal the same staining intensities as age-matched controls PMID: 22847813
  97. Native transthyretin inhibits all preeclampsia-like features in the humanized mouse model. PMID: 24035612
  98. A subunit exchange method quantifies the kinetic stability of endogenous transthyretin in plasma; TTR kinetic stability correlates with the tafamidis plasma concentration. PMID: 24661308
  99. Binding of the natural ligands thyroxine or retinol-binding protein (RBP) by Ser52Pro variant TTR stabilizes the native tetrameric assembly, but neither protected the variant from proteolysis. PMID: 24474780
  100. 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson's disease. PMID: 23385359

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Involvement in disease Amyloidosis, transthyretin-related (AMYL-TTR); Hyperthyroxinemia, dystransthyretinemic (DTTRH); Carpal tunnel syndrome 1 (CTS1)
Subcellular Location Secreted, Cytoplasm
Protein Families Transthyretin family
Tissue Specificity Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Database Links

HGNC: 12405

OMIM: 105210

KEGG: hsa:7276

STRING: 9606.ENSP00000237014

UniGene: Hs.427202

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