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The TTR recombinant monoclonal antibody is produced using recombinant DNA technology and is suitable for detecting human TTR protein in ELISA and IHC applications. The gene responsible for coding the TTR monoclonal antibody is synthesized after sequencing the cDNA of the TTR antibody-producing hybridomas. These hybridomas are produced by fusing myeloma cells with B cells extracted from an animal that was immunized with a synthesized peptide derived from human TTR. Once the gene is synthesized, it is cloned into a vector and then transfected into cells for cultivation. The resulting TTR recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
The TTR (transthyretin) protein is a carrier protein that is involved in the transport of thyroid hormone and retinol (vitamin A) in the bloodstream. TTR is also involved in protecting the brain and nervous system by binding to and preventing the accumulation of amyloid beta protein, which is a hallmark of Alzheimer's disease. Mutations in the TTR gene can lead to the formation of abnormal TTR protein that can accumulate as amyloid fibrils, causing amyloidosis, a group of diseases characterized by the deposition of amyloid protein in tissues and organs.
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