Code | CSB-RA437590A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The TTR recombinant monoclonal antibody is created through recombinant DNA technology and is used to detect human TTR protein in ELISA and IHC applications. To create this antibody, the gene coding for the TTR monoclonal antibody is synthesized after sequencing the cDNA of the TTR antibody-producing hybridomas. The hybridomas are created by fusing myeloma cells with B cells isolated from an animal that was immunized with a synthesized peptide derived from human TTR. The synthesized gene is then cloned into a vector and transfected into cells for cultivation. The resulting TTR recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
TTR is a transport protein produced mainly in the liver and circulates in the blood. Its main function is to transport thyroxine (T4) and retinol-binding protein (RBP) in the blood. TTR is also present in the cerebrospinal fluid and plays a role in the transport of thyroxine across the blood-brain barrier. TTR is also involved in the regulation of amyloid beta (Aβ) metabolism. Mutations in the TTR gene are associated with familial amyloidotic polyneuropathy, a disease in which abnormal deposits of TTR protein accumulate in tissues and organs, leading to organ dysfunction.
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