IFNA1 Antibody, Biotin conjugated

Code CSB-PA365592HD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) IFNA1 Polyclonal antibody
Uniprot No. P01562
Target Names IFNA1
Alternative Names IFL antibody; IFN alpha antibody; IFN alpha 1/13 antibody; IFN alpha 1b antibody; IFN alphaD antibody; IFN antibody; IFN-alpha-1/13 antibody; IFNA@ antibody; IFNA1 antibody; IFNA1_HUMAN antibody; IFNA13 antibody; Interferon alpha 1 antibody; Interferon alpha-1/13 antibody; Interferon alpha-D antibody; Interferon alpha1 antibody; Interferon, alpha 13 antibody; LeIF D antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Interferon alpha-1/13 protein (24-189AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes
Gene References into Functions
  1. SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
  2. Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with hepatitis B virus infection, and IFNLR1-rs4649203 was associated with hepatitis B recovery. Moreover, the authors demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with hepatocellular carcinoma. PMID: 29080269
  3. HIV-1 IIIB infection of myeloid ThP-1 cells also reduced the IFN-alpha-mediated induction of the anti-viral gene, ISG15, but not MxA, revealing a functional consequence of this HIV-1-mediated immune evasion strategy. PMID: 29580840
  4. Therefore, these results demonstrate the importance of MxB in alpha interferon-mediated inhibition of HIV-1 infection. PMID: 29925663
  5. Our results illustrate a novel regulatory role of TWEAK, in which its activity positively regulates type I IFN pathway in lupus nephritis (LN) based on preclinical models. Our findings suggest TWEAK could act as a critical target in preventing renal damage in patients with LN. PMID: 29333443
  6. Myeloid cells contribute more to the whole blood interferon signature in systemic lupus erythematosus than their lymphocytic counterpart. Very similar leukocyte subsets reveal distinctive IFN signatures. IFN alpha mixes up composition of blood and leads to a preferential neutropenia, yielding relative lymphocytosis. PMID: 28357476
  7. the polymorphic variant of IFNA1 (-2) gene is associated with chronic HBV infection PMID: 27101083
  8. Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals. PMID: 27400930
  9. Data suggest a central role of XBP1 in TLR7-induced IFNalpha production and identify XBP1 as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases. PMID: 28408069
  10. Study shows IFN-alpha rapidly induces a profound shift in whole brain network structure, impairing global functional connectivity and the efficiency of parallel information exchange. PMID: 26697999
  11. The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses). PMID: 27544015
  12. MiR-181a is an important mediator for interferons-induced SAMHD1 expression in astrocytes and microglia, but not for inhibition of HIV-1 infection induced by IFN-alpha. PMID: 27219130
  13. the expression of certain TAM components was reduced as a result of prolonged degradation of MYD88 by Porphyromonas gingivalis infection. PMID: 28076786
  14. Type I interferons (IFNs) signature is seen in a significant proportion of anti-nuclear antibody-positive (ANA(+) individuals and appears to be associated with ANA titre and type of autoantibodies, rather than with the presence or development of clinical systemic autoimmune rheumatic diseases (SARDs) symptoms. PMID: 28245862
  15. study found that endogenous IFNalpha autocrinally promotes the expression of Interferon-Stimulated Gene (ISG) mRNAs in IL-3-, but not in IFNlambda3 plus IL-3-, treated plasmacytoid dendritic cells (pDCs); production of IFNalpha by IFNlambda3 plus IL-3-treated pDCs is mostly dependent on endogenously produced TNFalpha PMID: 27513213
  16. results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL PMID: 28600291
  17. These data suggest that plasmacytoid dendritic cells producing IFN-alpha and IL-33 play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis. PMID: 28373582
  18. These findings also identify STAT3 as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha responsiveness. PMID: 27988795
  19. Mothers of children affected by autoimmune congenital heart block had a significantly higher expression IFN-alpha. PMID: 28501799
  20. Suppression of the exogenous Type I IFN-induced Jak/STAT signaling by NSs might be one of the mechanisms of Severe fever with thrombocytopenia syndrome (SFTS) to evade host immune surveillance. PMID: 28234991
  21. the paper shows the data on the role of interferons -alpha and -beta in infections - not only commonly known viral infections, but also bacterial, fungal and parasitic. PMID: 28388697
  22. High Type I Interferon expression due to hypomethylation is associated with Systemic Lupus Erythematosus. PMID: 28085900
  23. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response. PMID: 27802159
  24. The synthetic IFNP molecule exerted its antitumor activity by upregulating the downstream genes involved in the STAT1 pathway and in apoptosis. Using a cell receptor binding assay, we showed that this Jurkat-binding peptide facilitated the binding affinity of IFNalpha to the cell surface type I IFN receptor PMID: 28578326
  25. KSHV-encoded viral IRF4 interacts with the host IRF7 and inhibits interferon-alpha production. PMID: 28342865
  26. Data indicate ARID3a(+) B cells as a type of effector B cell, and link ARID3a expression in B lymphocytes to interferon alpha (IFNa)-associated inflammatory responses in systemic lupus erythematosus (SLE). PMID: 27522115
  27. On one hand, hepatitis B virus activates MMP-9 in infected patients and leukocytes. On the other hand, MMP-9 facilitates hepatitis B virus replication through repressing IFN/JAK/STAT signaling, IFNAR1 function, and IFN-alpha action. PMID: 28122987
  28. Interferon-alpha Induces the apoptosis of Hela cells by activating both the intrinsic mitochondrial pathway and endoplasmic reticulum stress-induced pathway. PMID: 27827850
  29. Decreased interferon alpha (IFN-alpha) secretion induced by Toll-like receptor 7 and Toll-like receptor 8 (TLR7/TLR8) activation was observed in common variable immunodeficiency (CVID), which was recovered with Toll-like receptor 9 (TLR9) signaling. PMID: 27392462
  30. Plasmacytoid dendritic cells (pDCs) and type 1 interferon (FNalpha/beta)frequently accompanied plasmablast/plasma cells (PB/PCs). PMID: 27102764
  31. These results establish that activation of STAT pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha. PMID: 27855377
  32. IL-2 therapy should be used as a first- or second-line therapy following IFN-a therapy. IL-2 may have a lower response if it is used after molecular-targeted therapy or other treatments PMID: 27630356
  33. results show that IFNA1 rs1332190 and IFNA17 rs9298814 SNPs may play an important role in Crimean-Congo hemorrhagic fever susceptibility PMID: 26694082
  34. Interferon-alpha-induced TRIM22 interrupts hepatitis c virus replication by ubiquitinating NS5A. PMID: 25683609
  35. our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. PMID: 26259828
  36. the findings demonstrate that treatment with anti-CD20-hIFNalpha reverses resistance of B-NHL PMID: 26398317
  37. NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation. PMID: 26353965
  38. interferon (IFN)-alpha, weakens activation of the anti-bacterial interleukin (IL)-1/IL-22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi PMID: 26152778
  39. Shp-2 contributes to the control of respiratory syncytial virus replication and progeny production in pulmonary alveolar epithelial cells by interfering with IFN-alpha-induced Jak/Stat1 pathway activation PMID: 26119280
  40. Interferon alfa induces high response rates with low toxicity in patients with polycythemia vera. PMID: 26261238
  41. This study suggests that suppression of miR-122 induced by hepatitis B virus infection, leads to the inactivation of interferon expression, which in turn enhances hepatitis B virus replication. PMID: 25766860
  42. Data suggest that Viral microRNA hcmv-miR-UL112 subverts innate immunity by downregulating type I interferons IFN-alpha and IFN-beta signaling to inhibit natural killer (NK) cell cytotoxicity. PMID: 25530545
  43. Interferon-alpha and interferon-beta are at the crossroads of allergy and viral infections. (Review) PMID: 26026068
  44. The interaction between AIP and IRF7 is enhanced upon virus infection, and AIP potently inhibits IRF7-induced type I IFN (IFN-alpha/beta) production. PMID: 25911105
  45. Interferon-alpha inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling. PMID: 25784743
  46. Data show that chemokine CXCL13 production by monocytes required toll-like receptor 7 activation and secretion of interferon-alpha. PMID: 25667414
  47. Studies indicate that type I interfereon signaling cascade is initiated by the binding of the cytokines to the high-affinity interferon alpha receotor. PMID: 25747907
  48. Results show that histone-lysine N-methyltransferase Set7 facilitates hepatitis C virus (HCV) replication through the attenuation of interferon-alpha (IFN-alpha) signaling pathways and IFN-related effectors. PMID: 25681344
  49. Domain 2 of the hepatitis C virus core protein critically affected the magnitude of host IFN-alpha responses. PMID: 25552725
  50. Hepatitis C virus NS3-4A similarly diminished both human and mouse MAVS-dependent signaling in human and mouse cells and MAVS induces both type I and type III interferons, which together control the hepatitis C virus replication. PMID: 25609814
  51. HIV-1-triggered release of interferon-alpha/interferon-beta by plasmacytoid dendritic cells induces BAFF production in monocytes. PMID: 25637018
  52. The combination of interferon-alpha, interferon-beta, TNF-alpha, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. PMID: 25320280
  53. The steady-state production of IFN-alpha plays a role in amplification of antiviral responses to control the spread of RNA viral infection in human hepatocytes. PMID: 24587086
  54. Treatment of hepatitis C patients with IFN-alpha is associated with magnetic resonance spectroscopy (MRS)-visible changes in glutamatergic metabolism. PMID: 23659574
  55. upregulated expression in elite controllers (fraction of human population displaying resistance to HIV infection) PMID: 23751822
  56. Alterations of plasmacytoid dendritic cells (pDCs) in human type 1 diabetes (T1D) reveal a role of pDCs in driving the differentiation of T helper (Th)1 cells and suggests that pDCs may play a role in Th1-mediated human T1D immunopathogenesis. PMID: 24973447
  57. Our data demonstrate disturbances in DC number and function expressed most significantly in T1D relatives and point to a potential role of TLR9-induced IFN-alpha production in T1D development. PMID: 24709112
  58. Data indicate that Toll-like receptor 7, Toll-like receptor 9, and interferon-alpha expression levels were significantly increased in lupus patients. PMID: 24865418
  59. Data suggest that serum levels of cathelicidin LL37 and IFN-alpha may reflect both local renal inflammation and systemic inflammation. PMID: 24286516
  60. Association of IFN- alpha levels with clinical disease activity and severity suggests a role for IFN- alpha in disease perpetuation and may provide a plausible explanation for a negative effect of IFN-1 treatment in NMO patients. PMID: 24348680
  61. Results show that the A allele of -1823G/A single nucleotide polymorphism (SNP) within interferon-alpha IFNA1 gene was significantly associated with an increased risk of chronic HBV infection. PMID: 23566196
  62. Low concentration of PDGF-AB showed synergism with IFN-alpha in IFN-beta and -gamma induction. PMID: 24063997
  63. These data indicate that type I IFN, via an action of IFNAR1, mediates pulmonary arterial hypertension. PMID: 24334027
  64. Taken together, our study shows that IFN-alpha enhanced 5'-DFUR-induced apoptosis in gastric cancer cells by upregulation of TP expression, which is partially regulated by activation of ERK signaling PMID: 24027750
  65. Our results suggest that ISG15 overexpression could be developed into a powerful gene-therapeutic tool for treating IFN-alpha-resistant HCC. PMID: 24024201
  66. Data indicate the ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-alpha induction. PMID: 24269682
  67. Authors show that PP2Ac associates with Jak1/Tyk2/STAT1 and reduces Jak1/Tyk2/STAT1 phosphorylation resulting in an impairment of the IFNalpha-induced hepatitis C virus antiviral response. PMID: 23910645
  68. Findings do not support the hypothesis that decreasing brain-derived neurotrophic factor (BDNF) is the primary pathway by which IFN-alpha worsens depression. PMID: 23303061
  69. Suppression of TLR9-mediated IFNA1 secretion from peripheral blood mononuclear cells, by adrenoceptor stimulation reduced the lytic activity of Natural killer cells on K562 tumor cells. PMID: 23724117
  70. Interferon-induced MxA protein inhibits influenza A virus infection by retaining the incoming viral genome in the cytoplasm. PMID: 24049170
  71. These findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent myeloproliferative neoplasms. PMID: 23814052
  72. This study demonistrated that type I interferon signaling contributes to neuromyelitis optica pathogenesis. PMID: 23434493
  73. These results indicate that hepatitis B virus activates IL-8 gene expression by targeting the epigenetic regulation of the IL-8 promoter and that IL-8 may contribute to reduce viral sensitivity to IFN-alpha. PMID: 23890815
  74. Data indicate that suppressor of IKKepsilon (SIKE) inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production. PMID: 23649622
  75. Interferon-alpha restricts hepatitis C virus via actions of general and specific interferon-alpha effector genes. PMID: 23462180
  76. SOCS1 acts as a suppressor of type I IFN function against hepatitis C virus. PMID: 23237992
  77. These data support a model of coordinated cell- and ligand-specific expression of types I and III interferon. PMID: 22249201
  78. the critical function of the Ly49Q cytoplasmic domain immunoreceptor tyrosine-based inhibitory motif (ITIM) is restored in the regulation of IFN-alpha production by plasmacytoid dendritic cells through trangenic complementation. PMID: 23479228
  79. Type I IFN-dependent inhibition of T cell-derived interleukin (IL)-5 is mediated by IFN-alpha acting directly on activated T cells. PMID: 23382558
  80. Impaired IFN-alpha production from plasmacytoid dendritic cells (pDCs) may contribute to the immunopathogenesis of chronic HBV infection, which may be the result of a reduced amount of pDCs as well as decreased expression of TLR7 and TLR9 on pDCs PMID: 22684144
  81. Data indicate that concomitant treatment with gp120 reduced the levels of IFN-alpha, IFN-beta, TNF-alpha, IL-6, and IP-10 induced by CpG-A in plasmacytoid dendritic cells. PMID: 22814248
  82. Inflammatory cytokines, such as interferon alfa, alter basal ganglia activity and behavior in association with significant changes in presynaptic striatal dopamine function consistent with decreased dopamine synthesis or release. PMID: 23026954
  83. [review] At the molecular level IFN-alpha has multiple effects in a variety of malignancies. Its potent immune impact can clearly be suppressed by tumor tolerogenic mechanisms, explaining its limited clinical activity as monotherapy in metastatic melanoma. PMID: 23042723
  84. Studies indicate that upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease. PMID: 22192711
  85. IFN-alpha-derived signals program human naive CD8 T cells to become highly responsive to secondary antigen stimulation. PMID: 22925929
  86. Data indicate that reversal of histone H3K9/K14 acetylation by histone deacetylase 3 (HDAC3) is required for attenuation of interferon-A (IFN-A) gene transcription during viral infection. PMID: 22685561
  87. HIV delays pDC IFN-alpha production and pDC activation via SYK phosphory PMID: 22693567
  88. High level of plasma IFN-alpha may be related to nephritis, thrombocytopenia, and autoantibodies in systemic lupus erythematosus compared with those of healthy controls. PMID: 21120500
  89. IFN-alpha acts synergistically with IFN-gamma to support development of strong effector functions, whereas IL-12 induces high T-bet transcription factor expression and strong function in the absence of IFN-gamma signaling. PMID: 22706089
  90. Calreticulin suppresses the production of endogenous IFN-alpha . PMID: 22661095
  91. Significant associations between serum levels of TNF-alpha and type I IFN and clinical manifestations exist in a sarcoidosis cohort that differ significantly by self-reported ancestry. PMID: 22195005
  92. Subacute cutaneous lupus erythematosus and discoid lupus erythematosus have an IFN signature, as seen in systemic lupus erythematosus which support a shared pathogenesis between systemic lupus erythematosus and subtypes of cutaneous lupus erythematosus. PMID: 22242767
  93. Studies suggest that genetically determined endogenous elevations in IFN-alpha predispose to systemic lupus erythematosus (SLE). PMID: 21923413
  94. IFNalpha-induced PLSCR1 associates with the cytoskeleton after exposure to alpha-toxin, and cellular depletion of PLSCR1 negates IFN-induced protection from alpha-toxin. PMID: 22264514
  95. Studies indicate that IFN-alpha and beta (type I interferons) and IFN-signaling in the pathogenesis of certain autoimmune inflammatory diseases. PMID: 22149411
  96. Nucleocapsid protein of measles virus blocks host IFN-alpha/beta and gamma- responses. PMID: 22226324
  97. Studies indicate that interferon-alpha (IFNalpha) and IFNbeta, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral and bacterial infections. PMID: 22222875
  98. Latent Epstein-Barr virus infection may contribute to the inflammatory milieu in active multiple sclerosis lesions by activating innate immune responses, e.g., IFNalpha production. PMID: 22156987
  99. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNalpha via accelerating the degradation of its receptor. PMID: 21821707
  100. In patients with anti-double stranded DNA antibodies, the IFN induced with helicase C domain 1 (IFIH1) risk allele increases sensitivity to IFN-alpha signaling. PMID: 21705624

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Subcellular Location Secreted
Protein Families Alpha/beta interferon family
Database Links

HGNC: 5417

OMIM: 147578

KEGG: hsa:3439

STRING: 9606.ENSP00000276927

UniGene: Hs.37026


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