LMTK2 Antibody

Code CSB-PA022099
Size US$297
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  • Western blot analysis of extracts from LOVO cells, using LMTK2 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using LMTK2 antibody.
  • Immunofluorescence analysis of HepG2 cells, using LMTK2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LMTK2 Polyclonal antibody
Uniprot No.
Target Names
LMTK2
Alternative Names
AATYK 2 antibody; AATYK2 antibody; Apoptosis associated tyrosine kinase 2 antibody; Apoptosis-associated tyrosine kinase 2 antibody; Brain enriched kinase antibody; Brain-enriched kinase antibody; BREK antibody; CDK5/p35 regulated kinase antibody; CDK5/p35-regulated kinase antibody; CPRK antibody; cyclin-dependent kinase 5/p35-regulated kinase antibody; FLJ46659 antibody; hBREK antibody; KIAA1079 antibody; Kinase phosphatase inhibitor 2 antibody; Kinase/phosphatase/inhibitor 2 antibody; KPI 2 antibody; KPI-2 antibody; KPI2 antibody; Lemur tyrosine kinase 2 antibody; LMR 2 antibody; LMR2 antibody; LMTK 2 antibody; Lmtk2 antibody; LMTK2_HUMAN antibody; PPP1R100 antibody; protein phosphatase 1; regulatory subunit 100 antibody; Serine/threonine protein kinase KPI 2 antibody; Serine/threonine protein kinase KPI2 antibody; Serine/threonine protein kinase LMTK 2 antibody; Serine/threonine protein kinase LMTK2 antibody; Serine/threonine-protein kinase KPI-2 antibody; Serine/threonine-protein kinase LMTK2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human LMTK2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Phosphorylates PPP1C, phosphorylase b and CFTR.
Gene References into Functions
  1. both BIM and BCL2 proteins are regulated by LMTK2 in a GSK3beta- and PP1A-dependent manner. PMID: 28040547
  2. Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life. PMID: 26559041
  3. Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor transcriptional activity. PMID: 26008968
  4. Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. PMID: 24727471
  5. The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm. PMID: 23114966
  6. We describe a new signalling pathway within the nervous system that links cdk5/p35 with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction PMID: 22220831
  7. Low LMTK2 expression is associated with the development of prostate cancer. PMID: 20569440
  8. KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes PMID: 12393858
  9. Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5/p35; Cdk5/p35 inhibits cprk activity PMID: 12832520
  10. BREK, Brain Enriched Kinase, is a new member of the family of protein serine/threonine kinases; plays important roles in NGF-TrkA signalling in the brain [BREK] PMID: 15005709
  11. role of the segment KLHY in binding with protein phosphatase 1 PMID: 16428298
  12. Myosin VI and LMTK2 are required for the transport of cargo, such as the Transferrin Receptor, from early endosomes to the endocytic recycling compartment. PMID: 18029400
  13. Results show that BREK is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes and also suggest an involvement of myosin VI in this pathway. PMID: 18429820

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family
Tissue Specificity
Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
Database Links

HGNC: 17880

OMIM: 610989

KEGG: hsa:22853

STRING: 9606.ENSP00000297293

UniGene: Hs.444179

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