LMTK2 Antibody

1. both BIM and BCL2 proteins are regulated by LMTK2 in a GSK3beta- and PP1A-dependent manner. PMID: 28040547
2. Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life. PMID: 26559041
3. Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor transcriptional activity. PMID: 26008968
4. Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. PMID: 24727471
5. The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm. PMID: 23114966
6. We describe a new signalling pathway within the nervous system that links cdk5/p35 with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction PMID: 22220831
7. Low LMTK2 expression is associated with the development of prostate cancer. PMID: 20569440
8. KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes PMID: 12393858
9. Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5/p35; Cdk5/p35 inhibits cprk activity PMID: 12832520
10. BREK, Brain Enriched Kinase, is a new member of the family of protein serine/threonine kinases; plays important roles in NGF-TrkA signalling in the brain [BREK] PMID: 15005709
11. role of the segment KLHY in binding with protein phosphatase 1 PMID: 16428298
12. Myosin VI and LMTK2 are required for the transport of cargo, such as the Transferrin Receptor, from early endosomes to the endocytic recycling compartment. PMID: 18029400
13. Results show that BREK is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes and also suggest an involvement of myosin VI in this pathway. PMID: 18429820

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HGNC: 17880

OMIM: 610989

KEGG: hsa:22853

STRING: 9606.ENSP00000297293

UniGene: Hs.444179