Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1),partial

1. regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction PMID: 29377208
2. These experiments also confirmed that protein levels of CEACAM-1, which functions in cell adhesion, is dependent on LLO biosynthesis in vivo. Kato III cells and the MPDU1-rescued Kato IIIM cells therefore provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo. PMID: 29671116
3. The MAPK-driven CEACAM1p activity is mediated by ETS1. PMID: 29558679
4. CEACAM1 mRNA or protein expression are independent prognostic markers for ovarian cancer carcinomas. PMID: 30050594
5. We suggest that CEACAM1 could be a prognostic marker of oral squamous cell carcinoma and oral carcinoma in situ. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ PMID: 28887602
6. GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved. PMID: 27514845
7. CEACAM1 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti. PMID: 29122006
8. HBx, VEGF and CEACAM1 were widely expressed in HBV-related HCC. HBx may facilitate occurrence and progression of HBV-related HCC via down-regulating CEACAM1 and up-regulating VEGF. PMID: 28975984
9. these data identify CEACAM1 as a clinically highly interesting target in multiple sclerosis pathogenesis and open new therapeutic avenues for the treatment of the disease. PMID: 27435215
10. serum levels of CEACAM1 in healthy pregnant women were much lower than in non-pregnant women PMID: 28593707
11. CEACAM1 overexpression significantly suppressed MM cell proliferation, induced cell apoptosis, and inhibited cell invasion and migration possibly through activation of caspase-3 and downregulation of MMP-2 and MMP-9. PMID: 29486474
12. Data suggest that the serum level of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) may be used to discriminate gastrointestinal cancer patients from health controls. PMID: 28655144
13. In this paper, a dual-target electrochemical aptasensor has been developed for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)6(3+) electronic wires PMID: 28732346
14. Furthermore, the proposed aptasensor was successfully applied in determining CEA in serum samples, showing its superior prospects in clinical diagnosis. PMID: 28735043
15. we show here that Human Metapneumovirus (HMPV)-infected cells upregulates CEACAM1 to restrict HMPV infection PMID: 27634893
16. Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells. PMID: 27748756
17. Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. PMID: 27748768
18. Data show that SOX9 regulates CEACAM1 primarily via Sp1 and ETS1. PMID: 26885752
19. short cytoplasmic domain isoforms at the primary lesion invasion front associated with recurrence and prognosis of patients with colorectal liver metastasis after curative hepatectomy; expression of CEACAM1-4S enhances the tumor-initiating property of colorectal cancer cells PMID: 29180203
20. Results report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, and suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. . PMID: 28332308
21. SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
22. CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture. PMID: 27264178
23. In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6. PMID: 28292985
24. REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation PMID: 27695943
25. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1. PMID: 28385529
26. We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae. PMID: 27442026
27. use NMR cross-correlation measurements to examine the effect of glycosylation on CEACAM1-IgV dimerization and use residual dipolar coupling (RDC) measurements to characterize the solution structure of the non-glycosylated form. PMID: 27471271
28. miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis. PMID: 27302063
29. The diffuse and cytoplasmic expression of CD66a may involve the early stage of the hepatocellular carcinoma , and the loss of CD66a expression indicates tumor progression. PMID: 27377843
30. this study shows that the expression of CEACAM1 is correlated with advanced stage and could be independent risk factors for colorectal cancer PMID: 28038383
31. Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in hepatocellular carcinoma through epithelial-mesenchymal transition and tumor angiogenesis PMID: 28314278
32. CEACAM1 might be regarded as a marker of salivary glandular tumors. PMID: 27464654
33. CEACAM1 mediates bacterial adherence and transcellular transcytosis. PMID: 26081722
34. CEACAM1 might play an important role in ovarian tumor progression, especially in tumor metastasis PMID: 26653024
35. Osteosarcoma patients with higher CEACAM1 had relatively lower survival compared to those with low CEACAM1 and high serum CEACAM1 level was an independent prognostic factor for osteosarcoma PMID: 27074014
36. serum CEACAM1 is elevated over time in progressive melanoma patients who fail to respond to immunotherapy as opposed to responders and stable disease patients. PMID: 26688824
37. an MITF-CEACAM1 axis is suggested as a potential determinant of melanoma progression. PMID: 26301891
38. Collectively, these data suggest that vIL-6 modulates endothelial cell migration by upregulating the expression of cellular factors, including CEACAM1. PMID: 26646010
39. Taken together, our results demonstrate a systematic down-regulation of CEACAM1 in breast cancer and suggest that a strategy to restore CEACAM1 expression may be helpful for the treatment of breast cancer. PMID: 26341981
40. Elevated carcinoembryonic antigen expression is associated with recurrence for patients after resection for colorectal liver metastases. PMID: 25582745
41. Serum concentrations of CEACAM1 may serve as a useful indicator for the presence of breast cancer PMID: 26343926
42. High Carcinoembryonic Antigen expression is associated with colon and stomach cancer. PMID: 26107193
43. High carcinoembryonic antigen serum levels are associated with Lung Adenocarcinoma. PMID: 25987049
44. High levels of serum CEA, CA72-4, CA19-9 and TSGF are associated with Gastric Cancer. PMID: 25987051
45. Ceacam1L acts as a crucial factor in glioblastoma-initiating cell maintenance and tumorigenesis by activating c-Src/STAT3 signaling. Monomers of the cytoplasmic domain of Ceacam1L bound to c-Src and STAT3 and induced their phosphorylation. PMID: 26238781
46. Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro PMID: 24716460
47. In conclusion, CEACAM1-L isoform expression dominance is associated with invasion, metastasis, and recurrence in hepatocellular carcinoma. PMID: 24390710
48. our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs PMID: 25824372
49. CD66 is a potential tumor marker to differentiate lung adenocarcinoma-associated malignant pleural effusion from benign effusions. PMID: 25551300
50. CEACAM1 gene silencing inhibited the cell proliferation and promote the apoptosis in human glioma SHG44 cells. PMID: 25575053
51. CEACAM1-4L downregulated cell surface levels of the NKG2D ligands. PMID: 25744717
52. Results show that pancreatic cancer patients with CEACAM 1, 5 and 6 expression showed a significantly shortened overall survival and elevated serum values are correlated with distant metastasis suggesting a role in epithelial-mesenchymal transition. PMID: 25409014
53. The up-regulation of CEACAM1 expression in gastric adenocarcinoma may participate in tumorous angiogenesis, especially high expression of CEACAM1 promoted its capability of invasion and metastasis. PMID: 24846314
54. CEACAM1 long cytoplasmic domain isoform dominance is associated with chemoresistance PMID: 25547406
55. CEACAM1 increases the expression of Sox-2, which we show to be responsible for the CEACAM1-mediated enhanced proliferation of melanoma cells PMID: 24931667
56. CEACAM1 serves as a heterophilic ligand for TIM-3 that is required for its ability to mediate T-cell inhibition, and this interaction has a crucial role in regulating autoimmunity and anti-tumour immunity PMID: 25363763
57. CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses PMID: 24743304
58. High serum carcinoembryonic antigen level is associated with cholangiocarcinoma. PMID: 25368272
59. we provide evidence that CEACAM1's promoter and variable exon 7 cross-talk allowing IRF-1 to direct alternative splicing events PMID: 24650050
60. Our results demonstrated that more neutrophils infiltration and overexpression of CEACAM1 were associated with poor clinical outcomes in TSCC tissues. PMID: 24587171
61. CEACAM1 controls matrix metalloproteinase-9 secretion by neutrophils in postischemic inflammation at the blood brain barrier after stroke. PMID: 23780386
62. Among the 273 upregulated genes in the atypical vs typical subtype, GC (vitamin D-binding protein) and CEACAM1 (carcinoembryonic antigen family member) emerged as potent diagnostic markers. PMID: 24518592
63. Overall, these data indicate that expression of human CEACAM1 confers a reduced Opa-specific antibody response in vivo without affecting the overall immune response against other Outer membrane vesicle antigens. PMID: 23933369
64. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients. PMID: 24072270
65. CaMKIID specifically phosphorylates Thr-457 on CEACAM1-SF, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells. PMID: 24302721
66. Low Carcinoembryonic Antigen expression is associated with response to therapy in advanced non-small-cell lung cancer. PMID: 23991977
67. High carcinoembryonic antigen expression is associated with colorectal and gastric cancer. PMID: 23991991
68. High serum carcinoembryonic antigen expression is associated with lung cancer. PMID: 23992005
69. Here we report for the first time that CEACAM1 is expressed ontogenetically in oligodendrocytes of the developing rat brain PMID: 23651919
70. Elevated preoperative CEA concentration is associated with recurrence after curative resection in patients with stage IIA colorectal cancer. PMID: 23760586
71. increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis PMID: 23894299
72. High carcinoembryonic antigen expression is associated with lymph node metastasis in colon cancer. PMID: 23886200
73. Results indicate that a dynamic oligomer-to-monomer shift in surface-expressed CEACAM1 facilitates trans-homophilic binding and downstream effector signaling. PMID: 24005674
74. CEACAM1 might be a useful marker in early diagnosis of non-small-cell lung carcinoma PMID: 23885995
75. role in mutual stimulation of chemotactic migration between trophoblast and endometrial stromal cells PMID: 23349235
76. High serum Carcinoembryonic Antigen is associated with recurrence in rectal cancer. PMID: 23452434
77. conclude that CEACAM20 and CEACAM1 not only mark the lumina of adult prostate tissue but also play a critical role in the vitro generation of prostate organoids PMID: 23358633
78. Elevated Carcinoembryonic Antigen is associated with incomplete response to chemoradiation in patients with rectal cancer. PMID: 23010737
79. CEACAM1 inhibits both G-CSF production by myeloid cells and G-CSF-stimulated tumor angiogenesis PMID: 23319418
80. These results indicated that CEACAM1 was an inhibitor of cell-matrix adhesion PMID: 23219815
81. CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with beta-catenin. PMID: 23499736
82. In this review the role of CEACAM3 in neutrophil activation and its initiation of phagocytosis as a result of binding to bacterial Opa protein is discussed. PMID: 22922158
83. Studies suggest that Am80 promote bactericidal activities probably through coordinating the functional interaction of CD66 with CD18 to enhance the development of neutrophil immunity during granulopoiesis. PMID: 23243275
84. This is the first report to demonstrate the loss of CEACAM1 expression in hereditary CRC. PMID: 23038226
85. Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with liver transplantation. PMID: 22932077
86. Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity. De novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues. Review. PMID: 22751559
87. SOX9 expression increased from gastric nonneoplastic to neoplastic lesions and CEACAM1 expression patterns changed; their coexpression was also elevated, suggesting that SOX9 plays important roles in changing CEACAM1 expression and in tumor progression. PMID: 22209504
88. Data show that the higher expression of HBx and lower expression of CEACAM1 are correlated with invasion and metastasis of HBV related hepatocelular carcinoma. PMID: 22482415
89. CEACAM specific T84.1 antibody binds to tumour cells in the vicinity of blood vessels PMID: 22162753
90. SCC, CEA, Cyfra 21-1 and NSE are valuable in the early diagnosis of lung cancer among suspicious nodules in the lung, especially when they were assayed together for one patient. PMID: 22088515
91. upregulated expression plays role in the immunopathogenesis of oral lichen planusr PMID: 21671129
92. The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils. PMID: 22064717
93. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. PMID: 22143889
94. The prognosis of the patients with low CEACAM1 expression and high tumor pathological grade were poorer than those patients with high expression and low pathological grade, P < 0.05. Clinically. PMID: 22135912
95. High Carcinoembryonic Antigen expression is associated with recurrence in gastric cancer. PMID: 21695697
96. CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma. PMID: 20737948
97. Data suggest that plasma markers: CEACAM, ICAM-1, osteopontin, MIA, TIMP-1 and S100B particularly when assessed in combination, can be used to monitor patients for disease recurrenc. PMID: 21487066
98. These data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver. PMID: 21569294
99. CEACAM1-L dominance is important for colorectal cancer cells invasion and migration. PMID: 21413011
100. a mechanistically distinct Opa protein-independent interaction between Neisseria meningitidis and human CEACAM1. PMID: 21298042

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HGNC: 1814

OMIM: 109770

KEGG: hsa:634

STRING: 9606.ENSP00000161559

UniGene: Hs.512682