Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1),partial

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Code CSB-EP005157HU
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names CEACAM1
Uniprot No. P13688
Research Area Tags & Cell Markers
Alternative Names Antigen CD66; BGP 1; BGP; BGP-1; BGPI; Biliary glycoprotein 1; Biliary glycoprotein adhesion molecule; Biliary glycoprotein; Carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 1; CD66a; CD66a antigen; CEACAM1; CEAM1_HUMAN; meconium antigen 100
Species Homo sapiens (Human)
Source E.coli
Expression Region 35-428aa
Target Protein Sequence QLTTESMPFNVAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPG
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 63.3kDa
Protein Length Extracellular Domain
Tag Info N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Isoform 1
Gene References into Functions
  1. regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction PMID: 29377208
  2. These experiments also confirmed that protein levels of CEACAM-1, which functions in cell adhesion, is dependent on LLO biosynthesis in vivo. Kato III cells and the MPDU1-rescued Kato IIIM cells therefore provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo. PMID: 29671116
  3. The MAPK-driven CEACAM1p activity is mediated by ETS1. PMID: 29558679
  4. CEACAM1 mRNA or protein expression are independent prognostic markers for ovarian cancer carcinomas. PMID: 30050594
  5. We suggest that CEACAM1 could be a prognostic marker of oral squamous cell carcinoma and oral carcinoma in situ. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ PMID: 28887602
  6. GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved. PMID: 27514845
  7. CEACAM1 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti. PMID: 29122006
  8. HBx, VEGF and CEACAM1 were widely expressed in HBV-related HCC. HBx may facilitate occurrence and progression of HBV-related HCC via down-regulating CEACAM1 and up-regulating VEGF. PMID: 28975984
  9. these data identify CEACAM1 as a clinically highly interesting target in multiple sclerosis pathogenesis and open new therapeutic avenues for the treatment of the disease. PMID: 27435215
  10. serum levels of CEACAM1 in healthy pregnant women were much lower than in non-pregnant women PMID: 28593707
  11. CEACAM1 overexpression significantly suppressed MM cell proliferation, induced cell apoptosis, and inhibited cell invasion and migration possibly through activation of caspase-3 and downregulation of MMP-2 and MMP-9. PMID: 29486474
  12. Data suggest that the serum level of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) may be used to discriminate gastrointestinal cancer patients from health controls. PMID: 28655144
  13. In this paper, a dual-target electrochemical aptasensor has been developed for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)6(3+) electronic wires PMID: 28732346
  14. Furthermore, the proposed aptasensor was successfully applied in determining CEA in serum samples, showing its superior prospects in clinical diagnosis. PMID: 28735043
  15. we show here that Human Metapneumovirus (HMPV)-infected cells upregulates CEACAM1 to restrict HMPV infection PMID: 27634893
  16. Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells. PMID: 27748756
  17. Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. PMID: 27748768
  18. Data show that SOX9 regulates CEACAM1 primarily via Sp1 and ETS1. PMID: 26885752
  19. short cytoplasmic domain isoforms at the primary lesion invasion front associated with recurrence and prognosis of patients with colorectal liver metastasis after curative hepatectomy; expression of CEACAM1-4S enhances the tumor-initiating property of colorectal cancer cells PMID: 29180203
  20. Results report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, and suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. . PMID: 28332308
  21. SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
  22. CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture. PMID: 27264178
  23. In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6. PMID: 28292985
  24. REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation PMID: 27695943
  25. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1. PMID: 28385529
  26. We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae. PMID: 27442026
  27. use NMR cross-correlation measurements to examine the effect of glycosylation on CEACAM1-IgV dimerization and use residual dipolar coupling (RDC) measurements to characterize the solution structure of the non-glycosylated form. PMID: 27471271
  28. miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis. PMID: 27302063
  29. The diffuse and cytoplasmic expression of CD66a may involve the early stage of the hepatocellular carcinoma , and the loss of CD66a expression indicates tumor progression. PMID: 27377843
  30. this study shows that the expression of CEACAM1 is correlated with advanced stage and could be independent risk factors for colorectal cancer PMID: 28038383
  31. Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in hepatocellular carcinoma through epithelial-mesenchymal transition and tumor angiogenesis PMID: 28314278
  32. CEACAM1 might be regarded as a marker of salivary glandular tumors. PMID: 27464654
  33. CEACAM1 mediates bacterial adherence and transcellular transcytosis. PMID: 26081722
  34. CEACAM1 might play an important role in ovarian tumor progression, especially in tumor metastasis PMID: 26653024
  35. Osteosarcoma patients with higher CEACAM1 had relatively lower survival compared to those with low CEACAM1 and high serum CEACAM1 level was an independent prognostic factor for osteosarcoma PMID: 27074014
  36. serum CEACAM1 is elevated over time in progressive melanoma patients who fail to respond to immunotherapy as opposed to responders and stable disease patients. PMID: 26688824
  37. an MITF-CEACAM1 axis is suggested as a potential determinant of melanoma progression. PMID: 26301891
  38. Collectively, these data suggest that vIL-6 modulates endothelial cell migration by upregulating the expression of cellular factors, including CEACAM1. PMID: 26646010
  39. Taken together, our results demonstrate a systematic down-regulation of CEACAM1 in breast cancer and suggest that a strategy to restore CEACAM1 expression may be helpful for the treatment of breast cancer. PMID: 26341981
  40. Elevated carcinoembryonic antigen expression is associated with recurrence for patients after resection for colorectal liver metastases. PMID: 25582745
  41. Serum concentrations of CEACAM1 may serve as a useful indicator for the presence of breast cancer PMID: 26343926
  42. High Carcinoembryonic Antigen expression is associated with colon and stomach cancer. PMID: 26107193
  43. High carcinoembryonic antigen serum levels are associated with Lung Adenocarcinoma. PMID: 25987049
  44. High levels of serum CEA, CA72-4, CA19-9 and TSGF are associated with Gastric Cancer. PMID: 25987051
  45. Ceacam1L acts as a crucial factor in glioblastoma-initiating cell maintenance and tumorigenesis by activating c-Src/STAT3 signaling. Monomers of the cytoplasmic domain of Ceacam1L bound to c-Src and STAT3 and induced their phosphorylation. PMID: 26238781
  46. Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro PMID: 24716460
  47. In conclusion, CEACAM1-L isoform expression dominance is associated with invasion, metastasis, and recurrence in hepatocellular carcinoma. PMID: 24390710
  48. our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs PMID: 25824372
  49. CD66 is a potential tumor marker to differentiate lung adenocarcinoma-associated malignant pleural effusion from benign effusions. PMID: 25551300
  50. CEACAM1 gene silencing inhibited the cell proliferation and promote the apoptosis in human glioma SHG44 cells. PMID: 25575053
  51. CEACAM1-4L downregulated cell surface levels of the NKG2D ligands. PMID: 25744717
  52. Results show that pancreatic cancer patients with CEACAM 1, 5 and 6 expression showed a significantly shortened overall survival and elevated serum values are correlated with distant metastasis suggesting a role in epithelial-mesenchymal transition. PMID: 25409014
  53. The up-regulation of CEACAM1 expression in gastric adenocarcinoma may participate in tumorous angiogenesis, especially high expression of CEACAM1 promoted its capability of invasion and metastasis. PMID: 24846314
  54. CEACAM1 long cytoplasmic domain isoform dominance is associated with chemoresistance PMID: 25547406
  55. CEACAM1 increases the expression of Sox-2, which we show to be responsible for the CEACAM1-mediated enhanced proliferation of melanoma cells PMID: 24931667
  56. CEACAM1 serves as a heterophilic ligand for TIM-3 that is required for its ability to mediate T-cell inhibition, and this interaction has a crucial role in regulating autoimmunity and anti-tumour immunity PMID: 25363763
  57. CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses PMID: 24743304
  58. High serum carcinoembryonic antigen level is associated with cholangiocarcinoma. PMID: 25368272
  59. we provide evidence that CEACAM1's promoter and variable exon 7 cross-talk allowing IRF-1 to direct alternative splicing events PMID: 24650050
  60. Our results demonstrated that more neutrophils infiltration and overexpression of CEACAM1 were associated with poor clinical outcomes in TSCC tissues. PMID: 24587171
  61. CEACAM1 controls matrix metalloproteinase-9 secretion by neutrophils in postischemic inflammation at the blood brain barrier after stroke. PMID: 23780386
  62. Among the 273 upregulated genes in the atypical vs typical subtype, GC (vitamin D-binding protein) and CEACAM1 (carcinoembryonic antigen family member) emerged as potent diagnostic markers. PMID: 24518592
  63. Overall, these data indicate that expression of human CEACAM1 confers a reduced Opa-specific antibody response in vivo without affecting the overall immune response against other Outer membrane vesicle antigens. PMID: 23933369
  64. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients. PMID: 24072270
  65. CaMKIID specifically phosphorylates Thr-457 on CEACAM1-SF, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells. PMID: 24302721
  66. Low Carcinoembryonic Antigen expression is associated with response to therapy in advanced non-small-cell lung cancer. PMID: 23991977
  67. High carcinoembryonic antigen expression is associated with colorectal and gastric cancer. PMID: 23991991
  68. High serum carcinoembryonic antigen expression is associated with lung cancer. PMID: 23992005
  69. Here we report for the first time that CEACAM1 is expressed ontogenetically in oligodendrocytes of the developing rat brain PMID: 23651919
  70. Elevated preoperative CEA concentration is associated with recurrence after curative resection in patients with stage IIA colorectal cancer. PMID: 23760586
  71. increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis PMID: 23894299
  72. High carcinoembryonic antigen expression is associated with lymph node metastasis in colon cancer. PMID: 23886200
  73. Results indicate that a dynamic oligomer-to-monomer shift in surface-expressed CEACAM1 facilitates trans-homophilic binding and downstream effector signaling. PMID: 24005674
  74. CEACAM1 might be a useful marker in early diagnosis of non-small-cell lung carcinoma PMID: 23885995
  75. role in mutual stimulation of chemotactic migration between trophoblast and endometrial stromal cells PMID: 23349235
  76. High serum Carcinoembryonic Antigen is associated with recurrence in rectal cancer. PMID: 23452434
  77. conclude that CEACAM20 and CEACAM1 not only mark the lumina of adult prostate tissue but also play a critical role in the vitro generation of prostate organoids PMID: 23358633
  78. Elevated Carcinoembryonic Antigen is associated with incomplete response to chemoradiation in patients with rectal cancer. PMID: 23010737
  79. CEACAM1 inhibits both G-CSF production by myeloid cells and G-CSF-stimulated tumor angiogenesis PMID: 23319418
  80. These results indicated that CEACAM1 was an inhibitor of cell-matrix adhesion PMID: 23219815
  81. CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with beta-catenin. PMID: 23499736
  82. In this review the role of CEACAM3 in neutrophil activation and its initiation of phagocytosis as a result of binding to bacterial Opa protein is discussed. PMID: 22922158
  83. Studies suggest that Am80 promote bactericidal activities probably through coordinating the functional interaction of CD66 with CD18 to enhance the development of neutrophil immunity during granulopoiesis. PMID: 23243275
  84. This is the first report to demonstrate the loss of CEACAM1 expression in hereditary CRC. PMID: 23038226
  85. Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with liver transplantation. PMID: 22932077
  86. Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity. De novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues. Review. PMID: 22751559
  87. SOX9 expression increased from gastric nonneoplastic to neoplastic lesions and CEACAM1 expression patterns changed; their coexpression was also elevated, suggesting that SOX9 plays important roles in changing CEACAM1 expression and in tumor progression. PMID: 22209504
  88. Data show that the higher expression of HBx and lower expression of CEACAM1 are correlated with invasion and metastasis of HBV related hepatocelular carcinoma. PMID: 22482415
  89. CEACAM specific T84.1 antibody binds to tumour cells in the vicinity of blood vessels PMID: 22162753
  90. SCC, CEA, Cyfra 21-1 and NSE are valuable in the early diagnosis of lung cancer among suspicious nodules in the lung, especially when they were assayed together for one patient. PMID: 22088515
  91. upregulated expression plays role in the immunopathogenesis of oral lichen planusr PMID: 21671129
  92. The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils. PMID: 22064717
  93. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. PMID: 22143889
  94. The prognosis of the patients with low CEACAM1 expression and high tumor pathological grade were poorer than those patients with high expression and low pathological grade, P < 0.05. Clinically. PMID: 22135912
  95. High Carcinoembryonic Antigen expression is associated with recurrence in gastric cancer. PMID: 21695697
  96. CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma. PMID: 20737948
  97. Data suggest that plasma markers: CEACAM, ICAM-1, osteopontin, MIA, TIMP-1 and S100B particularly when assessed in combination, can be used to monitor patients for disease recurrenc. PMID: 21487066
  98. These data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver. PMID: 21569294
  99. CEACAM1-L dominance is important for colorectal cancer cells invasion and migration. PMID: 21413011
  100. a mechanistically distinct Opa protein-independent interaction between Neisseria meningitidis and human CEACAM1. PMID: 21298042

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Canalicular domain of hepatocyte plasma membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions, Found as dimer in the solution, Predominantly localized to the lateral cell membranes, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 6: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 8: Cell membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, secretory vesicle membrane, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Predominantly localized to the lateral cell membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity), Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961), SUBCELLULAR LOCATION: Cell projection, microvillus membrane, Single-pass type I membrane protein, Apical cell membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, CEA family
Tissue Specificity The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).
Database Links

HGNC: 1814

OMIM: 109770

KEGG: hsa:634

STRING: 9606.ENSP00000161559

UniGene: Hs.512682

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