CEACAM1 Antibody, Biotin conjugated

Code CSB-PA10749D0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CEACAM1 Polyclonal antibody
Uniprot No. P13688
Target Names CEACAM1
Alternative Names Antigen CD66 antibody; BGP 1 antibody; BGP antibody; BGP-1 antibody; BGPI antibody; Biliary glycoprotein 1 antibody; Biliary glycoprotein adhesion molecule antibody; Biliary glycoprotein antibody; Carcinoembryonic antigen related cell adhesion molecule 1 antibody; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) antibody; Carcinoembryonic antigen-related cell adhesion molecule 1 antibody; CD66a antibody; CD66a antigen antibody; CEACAM1 antibody; CEAM1_HUMAN antibody; meconium antigen 100 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1 protein (35-428AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Isoform 1
Gene References into Functions
  1. regulator of local immune response in the liver, whereby CEACAM1S seems to control regulatory T cell induction PMID: 29377208
  2. These experiments also confirmed that protein levels of CEACAM-1, which functions in cell adhesion, is dependent on LLO biosynthesis in vivo. Kato III cells and the MPDU1-rescued Kato IIIM cells therefore provide a novel model to examine the consequences of defective LLO biosynthesis both in vitro and in vivo. PMID: 29671116
  3. The MAPK-driven CEACAM1p activity is mediated by ETS1. PMID: 29558679
  4. CEACAM1 mRNA or protein expression are independent prognostic markers for ovarian cancer carcinomas. PMID: 30050594
  5. We suggest that CEACAM1 could be a prognostic marker of oral squamous cell carcinoma and oral carcinoma in situ. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ PMID: 28887602
  6. GNAS mutation is a highly specific test for IPMN. When GNAS testing is added to CEA and KRAS, a significantly greater overall accuracy (86.2%) is achieved. PMID: 27514845
  7. CEACAM1 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti. PMID: 29122006
  8. HBx, VEGF and CEACAM1 were widely expressed in HBV-related HCC. HBx may facilitate occurrence and progression of HBV-related HCC via down-regulating CEACAM1 and up-regulating VEGF. PMID: 28975984
  9. these data identify CEACAM1 as a clinically highly interesting target in multiple sclerosis pathogenesis and open new therapeutic avenues for the treatment of the disease. PMID: 27435215
  10. serum levels of CEACAM1 in healthy pregnant women were much lower than in non-pregnant women PMID: 28593707
  11. CEACAM1 overexpression significantly suppressed MM cell proliferation, induced cell apoptosis, and inhibited cell invasion and migration possibly through activation of caspase-3 and downregulation of MMP-2 and MMP-9. PMID: 29486474
  12. Data suggest that the serum level of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) may be used to discriminate gastrointestinal cancer patients from health controls. PMID: 28655144
  13. In this paper, a dual-target electrochemical aptasensor has been developed for simultaneous detection of carcinoembryonic antigen and mucin-1 based on metal ion electrochemical labels and Ru(NH3)6(3+) electronic wires PMID: 28732346
  14. Furthermore, the proposed aptasensor was successfully applied in determining CEA in serum samples, showing its superior prospects in clinical diagnosis. PMID: 28735043
  15. we show here that Human Metapneumovirus (HMPV)-infected cells upregulates CEACAM1 to restrict HMPV infection PMID: 27634893
  16. Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells. PMID: 27748756
  17. Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. PMID: 27748768
  18. Data show that SOX9 regulates CEACAM1 primarily via Sp1 and ETS1. PMID: 26885752
  19. short cytoplasmic domain isoforms at the primary lesion invasion front associated with recurrence and prognosis of patients with colorectal liver metastasis after curative hepatectomy; expression of CEACAM1-4S enhances the tumor-initiating property of colorectal cancer cells PMID: 29180203
  20. Results report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, and suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1-L displays a positive or negative role in tumor cells. . PMID: 28332308
  21. SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
  22. CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture. PMID: 27264178
  23. In enterocytic C2BBe1 cells, Candida albicans caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6. PMID: 28292985
  24. REVIEW: summarizes the vascular effects of CEACAM1 and focuses on its role in vascular morphogenesis and endothelial barrier regulation PMID: 27695943
  25. We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1. PMID: 28385529
  26. We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae. PMID: 27442026
  27. use NMR cross-correlation measurements to examine the effect of glycosylation on CEACAM1-IgV dimerization and use residual dipolar coupling (RDC) measurements to characterize the solution structure of the non-glycosylated form. PMID: 27471271
  28. miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis. PMID: 27302063
  29. The diffuse and cytoplasmic expression of CD66a may involve the early stage of the hepatocellular carcinoma , and the loss of CD66a expression indicates tumor progression. PMID: 27377843
  30. this study shows that the expression of CEACAM1 is correlated with advanced stage and could be independent risk factors for colorectal cancer PMID: 28038383
  31. Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in hepatocellular carcinoma through epithelial-mesenchymal transition and tumor angiogenesis PMID: 28314278
  32. CEACAM1 might be regarded as a marker of salivary glandular tumors. PMID: 27464654
  33. CEACAM1 mediates bacterial adherence and transcellular transcytosis. PMID: 26081722
  34. CEACAM1 might play an important role in ovarian tumor progression, especially in tumor metastasis PMID: 26653024
  35. Osteosarcoma patients with higher CEACAM1 had relatively lower survival compared to those with low CEACAM1 and high serum CEACAM1 level was an independent prognostic factor for osteosarcoma PMID: 27074014
  36. serum CEACAM1 is elevated over time in progressive melanoma patients who fail to respond to immunotherapy as opposed to responders and stable disease patients. PMID: 26688824
  37. an MITF-CEACAM1 axis is suggested as a potential determinant of melanoma progression. PMID: 26301891
  38. Collectively, these data suggest that vIL-6 modulates endothelial cell migration by upregulating the expression of cellular factors, including CEACAM1. PMID: 26646010
  39. Taken together, our results demonstrate a systematic down-regulation of CEACAM1 in breast cancer and suggest that a strategy to restore CEACAM1 expression may be helpful for the treatment of breast cancer. PMID: 26341981
  40. Elevated carcinoembryonic antigen expression is associated with recurrence for patients after resection for colorectal liver metastases. PMID: 25582745
  41. Serum concentrations of CEACAM1 may serve as a useful indicator for the presence of breast cancer PMID: 26343926
  42. High Carcinoembryonic Antigen expression is associated with colon and stomach cancer. PMID: 26107193
  43. High carcinoembryonic antigen serum levels are associated with Lung Adenocarcinoma. PMID: 25987049
  44. High levels of serum CEA, CA72-4, CA19-9 and TSGF are associated with Gastric Cancer. PMID: 25987051
  45. Ceacam1L acts as a crucial factor in glioblastoma-initiating cell maintenance and tumorigenesis by activating c-Src/STAT3 signaling. Monomers of the cytoplasmic domain of Ceacam1L bound to c-Src and STAT3 and induced their phosphorylation. PMID: 26238781
  46. Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro PMID: 24716460
  47. In conclusion, CEACAM1-L isoform expression dominance is associated with invasion, metastasis, and recurrence in hepatocellular carcinoma. PMID: 24390710
  48. our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs PMID: 25824372
  49. CD66 is a potential tumor marker to differentiate lung adenocarcinoma-associated malignant pleural effusion from benign effusions. PMID: 25551300
  50. CEACAM1 gene silencing inhibited the cell proliferation and promote the apoptosis in human glioma SHG44 cells. PMID: 25575053

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Canalicular domain of hepatocyte plasma membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions, Found as dimer in the solution, Predominantly localized to the lateral cell membranes, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 6: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 8: Cell membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, secretory vesicle membrane, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Predominantly localized to the lateral cell membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity), Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961), SUBCELLULAR LOCATION: Cell projection, microvillus membrane, Single-pass type I membrane protein, Apical cell membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, CEA family
Tissue Specificity The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).
Database Links

HGNC: 1814

OMIM: 109770

KEGG: hsa:634

STRING: 9606.ENSP00000161559

UniGene: Hs.512682


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