Recombinant Human Tubulin beta-3 chain (TUBB3), partial

1. Results demonstrated that TUBB3 mutations impair the interaction of DCC with polymerized TUBB3 in MTs and inhibit netrin-1-induced neurite outgrowth, branching and attraction. These results suggest a disease mechanism underlying TUBB3 mutation-associated axon guidance defects: mutations in TUBB3 disrupt engagement of netrin/DCC signaling with MT dynamics, resulting in specific defects of netrin-1-mediated axon projection. PMID: 29382549
2. The remarkable high prevalence of TUBB3 expression in head and neck squamous cell carcinomas emphasizes its putative relevance as a target for future drugs targeting TUBB3 PMID: 28640948
3. TUBB3 and TUBB4 are necessary for the transport and proper localization of N-cadherin within the plasma membrane. PMID: 28648944
4. The miR-34a/STMN1/betaIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy. PMID: 28275089
5. Tubulin beta 3 (TUBB3) expression was identified as a useful predictive factor for survival. PMID: 29491095
6. This is the first study that relates concurrent expression of Tubbeta3, ZEB1, and beta-catenin to abnormal epithelial and myofibroblast differentiation in idiopathic pulmonary fibrosis, providing indirect but robust evidence of miR-200 deregulation and epithelial to mesenchymal transition activation in idiopathic pulmonary fibrosis. PMID: 27586205
7. The authors found that transient TUBB3 activation, through ABCB1, in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance. PMID: 27284014
8. By linkage and sequencing analyses, we identified the mutation c.784C>T (p.R262C) in TUBB3 gene in six members of a Turkish family with congenital fibrosis of the extraocular muscles. PMID: 27428177
9. High TUBB3 expression is associated with Melanoma. PMID: 28024114
10. these results identify a broad spectrum of cancers that can at least sporadically express TUBB3. Testing of TUBB3 in cancer types eligible for taxane-based therapies could be helpful to identify patients who might best benefit from this treatment. PMID: 29022485
11. TUBB3 overexpression is linked to an aggressive subtype of urinary bladder cancers, which is characterized by increased genetic instability, p53 alterations, and rapid cell proliferation. PMID: 28025079
12. The central findings of our study are that TSA and VPA affect the expression of neuronal lineage genes in an rMSCs culture. After exposure to TSA or VPA, the expression of early neuronal gene decreases but equally the expression of mature neuron genes increases PMID: 28397704
13. a positive correlation was observed between Snail presence and TUBB3 upregulation in tested adenocarcinoma cell lines. PMID: 27188792
14. This elucidates a hitherto unknown role for this microtubule protein and provides insight into correlations between high betaIII-tubulin expression and poor patient outcome in this disease PMID: 27207668
15. TUBB3 involvement in breast cancer cells apoptosis PMID: 28075472
16. The expressions of TYMS, TUBB3 and STMN1 were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM staging in patients with gastric cancer. PMID: 28056823
17. It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K in counteracting this event. PMID: 26586574
18. Epitaxial growth of alpha1A/betaIII microtubules from heterogeneous brain seeds is inefficient but can be fully rescued by incorporating as little as 5% of brain tubulin into the homogeneous alpha1A/betaIII lattice. PMID: 27129203
19. TUBB3 mutations cause both Congenital Fibrosis of the Extraocular Muscles type 3 and malformations of cortical development. PMID: 26639658
20. The decreased expression of TUBB3 could be a significant marker for predicting unfavourable prognosis in patients with cutaneous malignant melanoma. PMID: 26426765
21. High TUBB3 mRNA expression was associated with breast cancer. PMID: 26406408
22. mutations proximal to the TUBB3 kinesin-binding site alter polymerization dynamics. PMID: 27046833
23. Functional characterization of MC1R-TUBB3 intergenic splice variants of the human melanocortin 1 receptor has been undertaken in response to ultraviolet irradiation. PMID: 26657157
24. TUBB3, TOP2A, CYP19A1 and CYP2D6 gene expression, but not protein expression, was associated with patient survival in breast cancer . PMID: 26252353
25. In advanced cervical squamous cell cancer, TUBB3 was highly expressed in 20.%% of cases. It had no impact on survival in patients treated with antimicrotubule agents. PMID: 26165688
26. Findings suggest that overexpression of Class III beta-tubulin, Sox2, and nuclear Survivin might be predictive of taxane resistance and poor progression-free survival in patients with stage III ovarian epithelial cancer. PMID: 26198101
27. High level of stathmin exhibited poor response to chemotherapy . Similar effects were not observed for b-III-tubulin. PMID: 25894372
28. Results show an overexpression of TUBB3 in breast cancer brain metastases and its expression was significantly associated with distant metastases. These findings suggest a novel role of TUBB3 in regulation of metastases and integrin-Src signaling. PMID: 25724666
29. Depletion of betaIII-tubulin from MCF7 breast cancer cells increased mitotic arrest by ixabepilon. Increased betaIII-tubulin may be an important contributor to the development of resistance to ixabepilone. PMID: 26416565
30. Data suggest that silencing of beta III-tubulin expression may be a potential therapeutic strategy to increase the long-term survival of pancreatic cancer patients. PMID: 25544769
31. blocking of the beta-III tubulin expression in colorectal cancer cells does not affect their viability, but reduces the cell adhesion to the extracellular matrix PMID: 26591579
32. Results show that cabazitaxel resistance mechanisms involve alterations in microtubule dynamicity, as manifested by higher expression of TUBB3 and decreased BRCA1. PMID: 25416788
33. These results therefore suggested that certain TUBB3 mutations may predominantly be associated with axonal peripheral neuropathy. PMID: 25482575
34. This review discusses the confirmation that Gli1 overexpression is associated with decreased response to tumor chemotherapy, it was possible to sensitize cells to epothilones after addition a suitable inhibitor. PMID: 25661915
35. High TUBB3 expression in NSCLC appeared to correlate with lower PTX sensitivity PMID: 25964544
36. This study revealed that TUBB3 is a moderately sensitive and highly specific tissue marker for discriminating peripheral intrahepatic cholangiocarcinomas from other primary liver tumours. PMID: 25039376
37. First report of an autosomal-dominant inheritance of the TUBB3 c.1228G>A mutation in a family provides new insights into the spectrum and variability of endocrine phenotypes associated with the TUBB3 E410K syndrome. PMID: 25559402
38. ERCC1 mRNA levels were higher in metastatic adenocarcinoma NSCLC; TUBB3 mRNA levels were significantly higher in poorly differentiated tumors and in advanced stage NSCLC, which indicates the poor prognosis. PMID: 24762590
39. Findings revealed how betaIII-tubulin influences tumor growth in NSCLC, defining new biologic functions and mechanism of action of betaIII-tubulin in tumorigenesis. PMID: 25414139
40. betaIII-tubulin down-regulated significantly sensitized NSCLC A549/Taxol cells to Paclitaxel PMID: 25130963
41. evidence for a direct linkage between HIF-2alpha and increased expression of betaIII-t by hypoxia PMID: 25244496
42. Our data support the use of TUBB3 staining in differentiating follicular lymphoma, including BCL2-negative cases, from follicular hyperplasia PMID: 24232867
43. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
44. The sensitivity of gastric cancer patients to paclitaxel treatment was inversely correlated with the mRNA and protein expression of class III beta-tubulin. PMID: 24722794
45. The expression level of TUBB3 may be a useful biomarker to predict the clinical outcomes of the taxane/vinorebine-based chemotherapy in patients with NSCLC. PMID: 24705847
46. Patients with exotropia, vertical gaze limitation, and ptosis do not have classic Moebius syndrome and may have TUBB3 mutations associated with CFEOM3. PMID: 24612975
47. TUBB3 was a strong predictive marker in recurrent and metastatic gastric cancer patients receiving taxane-based first-line palliative chemotherapy. PMID: 24053422
48. Sox9 allows the survival of ovarian cells upon hypoxic condition, through the activation of betaIII-tubulin expression. PMID: 24661907
49. High tubulin beta 3 expression is associated with malignant pleural mesothelioma. PMID: 23810210
50. Higher response rates were observed among betaIII-tubulin-positive patients. PMID: 23853246

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HGNC: 20772

OMIM: 600638

KEGG: hsa:10381

STRING: 9606.ENSP00000320295

UniGene: Hs.511743