Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein(TRADD)

Code CSB-EP621879HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. Q15628
Abbreviation TRADD
Relevance The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias TNFRSF1A-associated via death domain
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
Research Area others
Source E.coli
Gene Names TRADD
Protein Names Recommended name: Tumor necrosis factor receptor type 1-associated DEATH domain protein Short name= TNFR1-associated DEATH domain proteinAlternative name(s): TNFRSF1A-associated via death domain
Expression Region 1-312aa
Tag Info N-terminal GST-tagged
Mol. Weight 61.2kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12
Subcellular Location Nucleus, Cytoplasm, Cytoplasm, cytoskeleton
Tissue Specificity Found in all examined tissues.
Database Links

HGNC: 12030

OMIM: 603500

KEGG: hsa:8717

STRING: 9606.ENSP00000341268

UniGene: Hs.460996

Pathway MAPK signaling pathway
NF-kappa B signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
IL-17 signaling pathway
Adipocytokine signaling pathway

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