Recombinant Mouse Inducible T-cell costimulator (Icos), partial

1. this study shows that ICOS protects against mortality from acute lung injury through activation of IL-5(+) type 2 innate lymphocytes PMID: 28488693
2. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. PMID: 29352114
3. Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene. PMID: 27235509
4. Our results indicate that ICOS regulates the ontogeny and homeostasis of B6.Sle1 lupus prone mouse T follicular helper (TFH) cells and influences the function of TFH cells during aberrant germinal center B cell responses PMID: 27296665
5. this study reveals a previously unknown ICOS-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells PMID: 27135603
6. IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria PMID: 27812214
7. Fecal levels of Crp1 were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity. PMID: 26198302
8. these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection PMID: 26667167
9. the ICOS signaling has a regulatory effect on CD154/CD40 expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis. PMID: 26767258
10. data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool. PMID: 26249010
11. results indicate that ILC2s might interact with B7RP-1-expressing DCs in allergic inflammatory lung, and ICOS signaling can positively regulate the protease allergen-induced ILC2 activation followed by eosinophil infiltration into the lungs PMID: 26049110
12. these data show a role for IL-6 in promoting "effector" Tregs accrual with age likely through maintenance of ICOS expression. PMID: 26109645
13. These data demonstrate the importance of ICOS signals specifically for memory CD4(+) T-cell formation, while highlighting the potential of therapeutically targeting this pathway. PMID: 25754933
14. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. PMID: 25918344
15. ICOS signaling transiently inactivates FOXO1 to initiate a T follicular helper cell contingency that is completed in a FOXO1-dependent manner. PMID: 25692700
16. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. PMID: 25646266
17. our work reveals that the ICOS pathway potentiates the antitumor activity of adoptively transferred Tc17 cells PMID: 25576595
18. Data suggest that ICOS-L expression on dendritic cells may be negatively regulated by IL-10 and that ICOS-L expression on DC in the presence or absence of IL-10 costimulation may promote Treg or Th17 response, without significant impact on Th1. PMID: 24100657
19. Data suggest that inducible costimulator (ICOS) costimulation-dependent translational control may ensure targeted delivery of IL-4 to cognate B cells during T-B collaborations in the germinal center. PMID: 24486724
20. ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PMID: 23967339
21. Use of ICOS T-cell source from a knock-in mouse strain causes less severe graft-vs-host disease compared with ICOS wild-type T cells, but they induce much more aggressive disease than ICOS T cells from a knockout mouse strain. PMID: 23729441
22. Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. PMID: 23285133
23. results demonstrate a co-stimulation-independent function of ICOS, uncover a key role for bystander B cells in promoting the development of follicular T-helper cells, and reveal unsuspected sophistication in dynamic T-cell positioning in vivo PMID: 23619696
24. ICOS regulates Type 2 immunity in a tissue-specific manner, and plays a key role in driving Foxp3(+) Treg-cell expansion and function during helminth infections. PMID: 23319295
25. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival PMID: 22949644
26. Results indicate AP-1 transcription factors are involved in ICOS gene expression downstream of both TCR/CD28 signaling and cytokine receptor signaling. PMID: 22585681
27. Our findings demonstrate a crucial role of ICOS for the generation and suppressive function of Tregs conveying respiratory tolerance PMID: 22815292
28. Through a newly identified role for T effector cell/Treg (regulatory T) cell balance, together with its established function in the B cell immune system, ICOS emerges as a central mediator of adaptive immunity. PMID: 22661090
29. This study demonstrates that ICOS but not CXCR5 marks T cells with B helper activity induced by influenza virus infection and identifies germinal center T cells (T(GC)) as lymph node-resident CD4(+) ICOS(+) CXCR4(+) CXCR5(+) PSGL-1(lo) PD-1(hi) cells. PMID: 22532671
30. ICOS is critical for the homeostasis and functional stability of Foxp3(+) Tregs in prediabetic islets and maintenance of T1D protection. PMID: 22227569
31. study demonstrated that the surviving and proliferative Treg are ICOS(+) whereas the death-prone Treg are ICOS(-); moreover, ICOS(+) Treg contain much stronger suppressive activity than that of ICOS(-) Treg PMID: 22231701
32. CD28 and ICOS are synergistic in promoting graft vs. host disease after bone marrow transplantation. PMID: 21447398
33. ICOS deficiency resulted in a reduced Mycobacterium tuberculosis-specific CD8(+) T-cell response during late-stage infection PMID: 21337542
34. a population of CD4(+)CD25(+)FoxP3(+) T cells upregulates ICOS on in vivo sensitization and specifically suppresses hapten-reactive CD8(+) T cells both in vivo and in vitro. PMID: 20624644
35. high ICOS levels on effector T cells results in autoimmunity by augmenting the autoreactive B cell response and by dampening the effect of Treg cell suppression. PMID: 20022728
36. knock-out mice displayed reduced elevation of serum transaminases and reduced hepatocyte apoptosis in ConA-induced hepatitis PMID: 19914290
37. ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice. PMID: 19889730
38. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. PMID: 19915142
39. ICOS is a critical regulator of both Th1 and Th2 immune responses in vivo and has a role in controlling cutaneous Leishmania mexicana infection. PMID: 11801630
40. the difference in H4/ICOS expression on activated CD4(+) T cells, which is regulated among the mouse strains, may also regulate the polarization of T(h) cells PMID: 12039907
41. Identification of a costimulatory pathway for Icos, parallel to that of CD28, defines its critical role in the protective Th1-type response required for resistance to Toxoplasma gondi. PMID: 12097399
42. Results of a study that examined tumor growth and the survival of mice injected with a tumor expressing the ICOS ligand, B7RP-1, indicate that natural killer cell functions are regulated by ICOS. PMID: 12244160
43. The involvement of the Icos-B7h costimulatory pathway has been demonstrated in the development and progression of collagen-induced arthritis. PMID: 12370365
44. ICOS costimulation is crucial for protective immunity against oral infection with the intracellular bacterium Listeria monocytogenes. PMID: 12421962
45. ICOS plays a clear role in the primary response to viruses at the level of Ab production, germinal center formation and Th cytokine production PMID: 12432568
46. ICOS provides co-stimulation to memory t-cells [review] PMID: 12456021
47. ICOS(high) T cells were highly and selectively linked to the anti-inflammatory cytokine IL-10. PMID: 12538658
48. generated a mutant ICOS gene that contains the CD28 YMNM motif and measured IL-2 promoter activation after ICOS ligation PMID: 12538664
49. ICOS signaling is involved in the initial clonal expansion of primary and primed Th1 and Th2 cells in response to immunization, and its interaction with its ligand B7RP-1 is essential for the ability of these cells to support B cell responses. PMID: 12594252
50. Mechanisms of H4/ICOS costimulation: effects on proximal TCR signals and MAP kinase pathways. PMID: 12594849

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KEGG: mmu:54167

STRING: 10090.ENSMUSP00000099891

UniGene: Mm.42044