Recombinant Mouse Inducible T-cell costimulator(Icos),partial

Code CSB-YP896269MO
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Source Yeast
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Code CSB-EP896269MO
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Source E.coli
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Code CSB-EP896269MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP896269MO
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Source Baculovirus
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Code CSB-MP896269MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Icos; Ailim; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD28 and CTLA-4-like protein; CCLP; CD28-related protein 1; CRP-1; CD antigen CD278
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Gene References into Functions
  1. this study shows that ICOS protects against mortality from acute lung injury through activation of IL-5(+) type 2 innate lymphocytes PMID: 28488693
  2. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. PMID: 29352114
  3. Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene. PMID: 27235509
  4. Our results indicate that ICOS regulates the ontogeny and homeostasis of B6.Sle1 lupus prone mouse T follicular helper (TFH) cells and influences the function of TFH cells during aberrant germinal center B cell responses PMID: 27296665
  5. this study reveals a previously unknown ICOS-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells PMID: 27135603
  6. IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria PMID: 27812214
  7. Fecal levels of Crp1 were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity. PMID: 26198302
  8. these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection PMID: 26667167
  9. the ICOS signaling has a regulatory effect on CD154/CD40 expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis. PMID: 26767258
  10. data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool. PMID: 26249010
  11. results indicate that ILC2s might interact with B7RP-1-expressing DCs in allergic inflammatory lung, and ICOS signaling can positively regulate the protease allergen-induced ILC2 activation followed by eosinophil infiltration into the lungs PMID: 26049110
  12. these data show a role for IL-6 in promoting "effector" Tregs accrual with age likely through maintenance of ICOS expression. PMID: 26109645
  13. These data demonstrate the importance of ICOS signals specifically for memory CD4(+) T-cell formation, while highlighting the potential of therapeutically targeting this pathway. PMID: 25754933
  14. ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. PMID: 25918344
  15. ICOS signaling transiently inactivates FOXO1 to initiate a T follicular helper cell contingency that is completed in a FOXO1-dependent manner. PMID: 25692700
  16. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. PMID: 25646266
  17. our work reveals that the ICOS pathway potentiates the antitumor activity of adoptively transferred Tc17 cells PMID: 25576595
  18. Data suggest that ICOS-L expression on dendritic cells may be negatively regulated by IL-10 and that ICOS-L expression on DC in the presence or absence of IL-10 costimulation may promote Treg or Th17 response, without significant impact on Th1. PMID: 24100657
  19. Data suggest that inducible costimulator (ICOS) costimulation-dependent translational control may ensure targeted delivery of IL-4 to cognate B cells during T-B collaborations in the germinal center. PMID: 24486724
  20. ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PMID: 23967339
  21. Use of ICOS T-cell source from a knock-in mouse strain causes less severe graft-vs-host disease compared with ICOS wild-type T cells, but they induce much more aggressive disease than ICOS T cells from a knockout mouse strain. PMID: 23729441
  22. Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. PMID: 23285133
  23. results demonstrate a co-stimulation-independent function of ICOS, uncover a key role for bystander B cells in promoting the development of follicular T-helper cells, and reveal unsuspected sophistication in dynamic T-cell positioning in vivo PMID: 23619696
  24. ICOS regulates Type 2 immunity in a tissue-specific manner, and plays a key role in driving Foxp3(+) Treg-cell expansion and function during helminth infections. PMID: 23319295
  25. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival PMID: 22949644
  26. Results indicate AP-1 transcription factors are involved in ICOS gene expression downstream of both TCR/CD28 signaling and cytokine receptor signaling. PMID: 22585681
  27. Our findings demonstrate a crucial role of ICOS for the generation and suppressive function of Tregs conveying respiratory tolerance PMID: 22815292
  28. Through a newly identified role for T effector cell/Treg (regulatory T) cell balance, together with its established function in the B cell immune system, ICOS emerges as a central mediator of adaptive immunity. PMID: 22661090
  29. This study demonstrates that ICOS but not CXCR5 marks T cells with B helper activity induced by influenza virus infection and identifies germinal center T cells (T(GC)) as lymph node-resident CD4(+) ICOS(+) CXCR4(+) CXCR5(+) PSGL-1(lo) PD-1(hi) cells. PMID: 22532671
  30. ICOS is critical for the homeostasis and functional stability of Foxp3(+) Tregs in prediabetic islets and maintenance of T1D protection. PMID: 22227569
  31. study demonstrated that the surviving and proliferative Treg are ICOS(+) whereas the death-prone Treg are ICOS(-); moreover, ICOS(+) Treg contain much stronger suppressive activity than that of ICOS(-) Treg PMID: 22231701
  32. CD28 and ICOS are synergistic in promoting graft vs. host disease after bone marrow transplantation. PMID: 21447398
  33. ICOS deficiency resulted in a reduced Mycobacterium tuberculosis-specific CD8(+) T-cell response during late-stage infection PMID: 21337542
  34. a population of CD4(+)CD25(+)FoxP3(+) T cells upregulates ICOS on in vivo sensitization and specifically suppresses hapten-reactive CD8(+) T cells both in vivo and in vitro. PMID: 20624644
  35. high ICOS levels on effector T cells results in autoimmunity by augmenting the autoreactive B cell response and by dampening the effect of Treg cell suppression. PMID: 20022728
  36. knock-out mice displayed reduced elevation of serum transaminases and reduced hepatocyte apoptosis in ConA-induced hepatitis PMID: 19914290
  37. ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice. PMID: 19889730
  38. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. PMID: 19915142
  39. ICOS is a critical regulator of both Th1 and Th2 immune responses in vivo and has a role in controlling cutaneous Leishmania mexicana infection. PMID: 11801630
  40. the difference in H4/ICOS expression on activated CD4(+) T cells, which is regulated among the mouse strains, may also regulate the polarization of T(h) cells PMID: 12039907
  41. Identification of a costimulatory pathway for Icos, parallel to that of CD28, defines its critical role in the protective Th1-type response required for resistance to Toxoplasma gondi. PMID: 12097399
  42. Results of a study that examined tumor growth and the survival of mice injected with a tumor expressing the ICOS ligand, B7RP-1, indicate that natural killer cell functions are regulated by ICOS. PMID: 12244160
  43. The involvement of the Icos-B7h costimulatory pathway has been demonstrated in the development and progression of collagen-induced arthritis. PMID: 12370365
  44. ICOS costimulation is crucial for protective immunity against oral infection with the intracellular bacterium Listeria monocytogenes. PMID: 12421962
  45. ICOS plays a clear role in the primary response to viruses at the level of Ab production, germinal center formation and Th cytokine production PMID: 12432568
  46. ICOS provides co-stimulation to memory t-cells [review] PMID: 12456021
  47. ICOS(high) T cells were highly and selectively linked to the anti-inflammatory cytokine IL-10. PMID: 12538658
  48. generated a mutant ICOS gene that contains the CD28 YMNM motif and measured IL-2 promoter activation after ICOS ligation PMID: 12538664
  49. ICOS signaling is involved in the initial clonal expansion of primary and primed Th1 and Th2 cells in response to immunization, and its interaction with its ligand B7RP-1 is essential for the ability of these cells to support B cell responses. PMID: 12594252
  50. Mechanisms of H4/ICOS costimulation: effects on proximal TCR signals and MAP kinase pathways. PMID: 12594849

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen.
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