Recombinant Mouse Myogenin (Myog)

1. Autophagy proteins were measured to understand the molecule mechanisms. We also inhibited hypoxic autophagy and examined the changes in myogenin expression, myotubes formation, and apoptosis. PMID: 28706950
2. The study demonstrates an essential role of Setd2 in myoblast proliferation and differentiation, and uncovers Setd2-mediated molecular mechanism through regulating MyoG and p21. PMID: 28130125
3. Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression. PMID: 27680312
4. This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradation. PMID: 27780863
5. Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin. PMID: 26563778
6. In summary, our results implicate that metastatic properties of some RMS subtypes might be linked to c-Myb function. PMID: 26462877
7. Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways PMID: 26483211
8. Combining chemical with mechanical factor increases expression and there was no significant difference in MyoG expression of ESCs- and MSCs-chemical + mechanical groups PMID: 25330622
9. TWIST reverses muscle cell differentiation through promoter binding and down-regulation of myogenin. PMID: 24188104
10. miR-186 inhibits muscle cell differentiation through myogenin regulation. PMID: 24385428
11. P38alpha-defective, Myog-expressing myoblasts fail to form multinucleated myotubes. PMID: 22847234
12. Expression of myogenin probably influences the shift from glycolytic metabolism towards oxidative metabolism in differentiating myoblasts. PMID: 24055422
13. Myogenin expression and myogenesis were nearly abolished in the absence of both AMPKalpha1 and AMPKalpha2, while enhanced AMPK activity promoted myogenesis and myotube formation. PMID: 24043309
14. data demonstrated that AMPKalpha1 but not AMPKalpha2 stimulates myogenin expression and myogenesis via phosphorylation of HDAC5 at Ser 259 and 498, which provides an important mechanisms linking AMPK to myogenic differentiation PMID: 23926128
15. PI3K and AKT regulated skeletal muscle differentiation by regulating the expression of Myogenin and MCK. PMID: 23732671
16. These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin expression may be part of the mechanism of action. PMID: 23211595
17. the FACT complex promotes myogenin-dependent transcription PMID: 23364797
18. RAGE signaling physiologically repressed Pax7 transcription in stellite cells by upregulating myogenin, thereby accelerating muscle regeneration and limiting satellite cell self-renewal. PMID: 22328527
19. alphaNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression. corepressors at target promoters. PMID: 23092676
20. the important role of myogenin in maintaining terminal muscle cell differentiation PMID: 22235349
21. TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation. PMID: 21701496
22. Ptpla regulates myogenesis through Myog. PMID: 22106411
23. Myog and the signaling cascades regulating its induction following muscle denervation may represent novel targets for therapies aimed at reducing denervation-induced muscle atrophy. PMID: 21465538
24. suggest a novel mechanism for transcriptional repression by TSHZ3 in which TSHZ3 and BAF57 cooperate to modulate MyoD activity on the Myog promoter to regulate skeletal muscle differentiation. PMID: 21543328
25. myogenin was dispensable for muscle regeneration. Factors associated with muscle fatigue, metabolism, and proteolysis were significantly altered in mdx:Myog-deleted mice PMID: 21264243
26. CTCF enhances the myogenic potential of MyoD and myogenin and establishes direct interactions with MyoD, indicating that CTCF regulates MRF-mediated muscle differentiation. PMID: 21288905
27. alpha-syntrophin plays an important role in regulating myogenesis by modulating myogenin expression PMID: 21179410
28. Results analyze the DNA methylation pattern of the 5'-flanking of the myogenin gene, a positive regulator of muscle differentiation with no CpG island and low CpG density, in both C2C12 muscle satellite cells and embryonic muscle. PMID: 20935518
29. Myogenin plays a dual role as both a regulator of muscle development and an inducer of neurogenic atrophy PMID: 20887891
30. Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myog gene are discussed. PMID: 20498275
31. S-adenosylmethionine-sulphate-p-toluenesulphonate (SAM) inhibits myogenin expression by delaying the demethylation of specific CpG in differentiating myoblasts PMID: 11728447
32. p38 mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase, and calcineurin-mediated signaling pathways transcriptionally regulate its expression PMID: 12058061
33. role of C-terminus in upregulation of MEF2C expression PMID: 12135755
34. Myogenin was detected by cell culture immunostaining using the polyclonal anti-mouse myogenin. PMID: 12871697
35. data indicate two distinct innervation-dependent mechanisms restrain myogenin activity: an inactivation mechanism mediated by phosphorylation of myogenin at T87 and a second mechanism that regulates myg gene activity independently of T87 phosphorylation PMID: 14966278
36. Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. PMID: 15322112
37. Myog-deleted mice were 30% smaller than control mice, suggesting that the absence of myogenin disrupted general body growth. PMID: 16407395
38. a HDAC-Dach2-myogenin signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle PMID: 17075071
39. Brg1 is required for the continued production of the myogenin protein in newborn skeletal muscle tissue; the skeletal muscle phenotype is maintained by myogenin and the continuous activity of Brg1-based SWI/SNF chromatin-remodeling enzymes PMID: 17194702
40. caveolin-3 levels are downregulated by nitric oxide through the interaction with myogenin, the transcription factor for caveolin-3 PMID: 17519233
41. transcription of Cugbp1 gene in muscle is regulated by myogenin and E proteins PMID: 17531403
42. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR PMID: 17873280
43. The results identify new target genes for myogenin and show that myogenin's target gene selectivity is not based solely on binding site sequences. PMID: 17904117
44. IL-10 plays a protective role in nonhematopoietic cells by suppressing the ability of exogenous IL-1beta to inhibit IGF-I-induced myogenin and myosin heavy chain expression in myoblasts PMID: 18270299
45. Despite a lack of skeletal muscle defects in Myog-deleted mice during postnatal life and differentiation of Myog-deleted adult muscle stem cells, the loss of myogenin profoundly altered gene expression in muscle stem cells and adult skeletal muscle. PMID: 18721801
46. properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter. PMID: 18851836
47. Ski is necessary for muscle terminal differentiation and that it exerts this role, at least in part, through its association with Six1 and Eya3 to regulate the Myog transcription PMID: 19008232
48. PAX3 mRNA is an Staufen 1-mediated mRNA decay target whose decay promotes myogenesis whereas myogenin mRNA is a classical nonsense-mediated mRNA decay target encoding a protein required for myogenesis PMID: 19095803
49. HDAC4/myogenin positive feedback loop that coordinates gene induction and repression underlying muscle phenotypic changes after muscle denervation. PMID: 19109424
50. Results suggest that MAFbx functions as an F-box protein in the SCF complex for ubiquitination of myogenin. PMID: 19631210

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KEGG: mmu:17928

STRING: 10090.ENSMUSP00000027730

UniGene: Mm.16528