Recombinant Mouse Neuroglobin (Ngb)

1. This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice. PMID: 29101592
2. NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model. PMID: 29098407
3. Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability. PMID: 29031607
4. Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning PMID: 27928027
5. Ngb can bind to mitochondrial complex III subunit Cyc1, leading to suppression of oxygen-glucose deprivation -mediated complex III activity. PMID: 26050086
6. Reduction of Ngb expression in mouse retina after optic nerve injury.Ngb role in neuroregeneration in mice after optic nerve injury. PMID: 28951213
7. Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator. PMID: 28391636
8. Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb. PMID: 25636685
9. Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling. PMID: 25616953
10. Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury. PMID: 26427474
11. Overexpression of neuroglobin reduced sensorimotor deficits following TBI. An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI may improve recovery. PMID: 24642455
12. reflect lesser perturbations produced by acute inhalation of combustion smoke in the Ngb overexpressing mouse, suggesting that Ngb mitigates mitochondrial dysfunction and neurotoxicity and raises the threshold of smoke inhalation-induced brain injury PMID: 24730682
13. A critical role for neuroglobin is demonstrated via its differential interaction with phosphatase and tensin homolog (PTEN) and Akt during neurite induction. PMID: 23904011
14. Neuroglobin overexpression resulted in a significant reduction in infarct volume 24 hours after brain ischemia. PMID: 24098534
15. Ngb overexpression can inhibit oxygen-glucose deprivation-induced mitochondria permeability transition opening in primary cultured mouse cortical PMID: 23639789
16. CREB may also mediate transcriptional regulation of neuroglobin gene. PMID: 23182882
17. This study demonistrated that Ngb over-expression reduced traumatic lesion volume. PMID: 22703519
18. mitochondria distribution of Ngb is clearly associated with and may contribute to Ngb's neuroprotection. PMID: 22659017
19. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. PMID: 22583764
20. Genetic elimination of neuroglobin evokes an increased behavioural response to light concomitant with increased Per1 gene expression in the suprachiasmatic nucleus. PMID: 22496809
21. Cerebral regulation of neuroglobin is related to maturational stage; hypoxia-induced neuroglobin up-regulation is modified by the hypoxia-inducible transcription factor (HIF) system. PMID: 22548980
22. Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo PMID: 22164238
23. NF-kappaB, Egr1 and Sp1 played important roles in the regulation of basal neuroglobin (Ngb) expression via specific interactions with the mouse Ngb promoter PMID: 22239089
24. Neuroglobin overexpression plays a neuroprotective role against retinal ischemia reperfusion injury due to decreasing of mitochondrial oxidative stress-mediated apoptosis. PMID: 22167093
25. Neuroglobin is part of the estradiol signaling mechanism that is activated to exert protective effects against hydrogen peroxide-induced neurotoxicity. PMID: 21335947
26. The study shows that the Fe-heme structure in solution and in the cryo-trapped Ngb-carbonmonoxy single crystal (which cracks at room temperature) are the same. PMID: 20879741
27. First report of Ngb present in reactive astroglia and in scar-forming astrocytes in response to different pathological conditions. In light of previously reported cyto-protective properties of Ngb, further insight may result in therapeutic ramifications. PMID: 20544857
28. The anatomical data indicate a role in NO signalling for cytoglobin and involvement in sleep-wake cycling for cytoglobin and neuroglobin PMID: 20331985
29. The dynamic features of neuroglobin demonstrate rearrangement of the inner space and highly active loop regions in solution. These imply that the conserved residue at the G5 site plays a key role in the physiological function of this unusual protein. PMID: 19820972
30. After dissociation from the heme iron, the CO ligand visits multiple docking sites identified unambiguously, and identified preferred heme-bound conformation PMID: 19960556
31. ligand binding and protein dynamics PMID: 12048231
32. role in supplying oxygen to mammalian retina PMID: 12409290
33. Neuroglobin mRNA was detected in all brain areas studied and in the peripheral nervous system. Most, but not all, nerve cells were labeled, suggesting differential expression of Ngb. PMID: 12435404
34. nitric oxide binding properties of neuroglobin PMID: 12480932
35. neuroglobin immunoreactivity was detected in specific brain regions with varying intensities and in the islet of Langerhans in the pancreas. PMID: 12796507
36. Neuroglobin is expressed on the protein level in many brain sites including cerebral cortex, thalamus and hypothalamus, nuclei of cranial nerves in the brainstem and cerebellum. PMID: 12850561
37. crystal structure of murine ferric (met) neuroglobin at 1.5 A reveals interesting features relevant to the ligand binding mechanism PMID: 15162488
38. Analysis of the neuroglobin genomic sequence identifies sequence motifs with similarity to the neuron-restrictive silencer element, possibly explaining a neuron-specific expression of neuroglobin. PMID: 15193759
39. oxygen binding in neuroglobin and cytoglobin is allosterically regulated and temperature-dependent PMID: 15299006
40. The heme relocation is accompanied by a significant decrease of structural disorder, especially of the EF loop, which may be the signal whereby Ngb communicates hypoxic conditions PMID: 15548613
41. This research showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. PMID: 15582755
42. the discovery of Ngb in astrocytes may provide some insight into how oxygen homeostasis is regulated in the brain PMID: 15657899
43. Neuroglobin is localised in photoreceptor inner segments, the plexiform layers and the ganglion cell layer. PMID: 15663964
44. Ngb is not regulated by pure hypoxia in vivo in the brain PMID: 16281909
45. The structural information on the heme pocket of mNgb was revealed by 14N EPR and it is in agreement with previous X-ray diffraction data on neuroglobins. PMID: 16596390
46. neuroglobin is expressed in distinct regions of the brain, and neuroglobin expression in the brain is not induced in response to chronic hypoxia. PMID: 16899760
47. Data show that the reduction of ferric neuroglobin by cytochrome b(5) is relatively slow, but the reaction between ferrous neuroglobin and ferric cytochrome c is very rapid. PMID: 16914148
48. These findings extend prior evidence for cytoprotection by neuroglobin and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms. PMID: 17098866
49. Ngb expression is correlated with reactive oxygen species scavenging. PMID: 17286577
50. characterized the heme sliding motion, the topological reorganization of the internal cavities, the dynamics of the distal histidine, and particularly the conformational change of the CD loop, whose flexibility depends ligand binding PMID: 17468165

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KEGG: mmu:64242

STRING: 10090.ENSMUSP00000021420

UniGene: Mm.41395