Recombinant Mouse Tumor necrosis factor receptor superfamily member 11A (Tnfrsf11a), partial

1. lactation increases physiological maxillary bone remodeling and orthodontic tooth movement, and both require activation of RANK/RANKL/OPG system PMID: 29382610
2. RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 signaling PMID: 30036881
3. TNFalpha and RANKL promote osteoclastogenesis by upregulating RANK via the NFkappaB pathway. PMID: 29512766
4. Results from this study demonstrate that RANK signalling in NPY neurons is involved in modulating NPY levels and through that matching bone mass to body weight. PMID: 29477253
5. the investigation of RANK and RANKL as possible novel immunotherapy targets in cancer is a rational approach. Here we have defined the mechanism of action of RANKL-RANK blockade in combination with anti-CTLA4, and provide insight into the combination efficacy observed in the case reports. PMID: 28634284
6. Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation. PMID: 28535663
7. This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK/Mitf signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture PMID: 28158928
8. RANKL/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer. PMID: 27241552
9. RANK rewires energy homeostasis in murine lung cancer cells and promotes expansion of lung cancer stem-like cells PMID: 29118048
10. Artesunate inhibits RANKL-induced osteoclastogenesis by suppressing the NF-kappaB signaling pathway. PMID: 28294321
11. Data suggest that mutations at position I248 in DE-loop of murine RANKL have effects on interaction of RANKL with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL = osteoclast differentiation factor; RANK = tumor necrosis factor receptor superfamily, member 11a protein) PMID: 28627025
12. The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF/IL-6 to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints. PMID: 27563728
13. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2+)storage and SERCA activity, ultimately affecting denervated skeletal muscle function. PMID: 26825123
14. present study shows that ginsenoside Rg3 protects against LPS-induced acute lung injury through inactivating the NF-kappaB signaling PMID: 26921732
15. In palmatine-treated mice, RANKL and OPG expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition. PMID: 26546523
16. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL/RANK affinity and osteoclastogenic capacity. PMID: 25864714
17. We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT response and mammary cell expansion PMID: 26095608
18. findings have uncovered a tumorigenic role for RANKL/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer PMID: 26061636
19. results indicate that the RANK IVVY motif cooperates with the TRAF-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis. PMID: 26276390
20. findings suggest CCN2 as a candidate of the fourth factor in the RANK/RANKL/OPG system for osteoclastogenesis, which regulates OPG and RANK via direct interaction PMID: 25554597
21. Recapitulating the W434X mutation by transcription activator-like effector nuclease-mediated targeted disruption of Tnfrsf11a within the region homologous to W434X in the macrophage-like cell line RAW264.7 impaired formation of osteoclast-like cells. PMID: 24859969
22. findings show that RANK siRNA delivered locally by a synthetic vector may be an effective approach for reducing osteolysis and may even stimulate bone formation in aseptic loosening of prosthetic implants. PMID: 25462844
23. silencing angiopoietin-like protein 4 protects against LPS-induced acute lung injury via regulating SIRT1/NF-kB signaling pathway PMID: 25727991
24. silencing of miR-503 using a specific antagomir in ovariectomy (OVX) mice increased RANK protein expression, promoted bone resorption PMID: 23821519
25. The OPG/RANKL/RANK axis plays critical roles in controlling inflammation in ischemic brains. PMID: 24847069
26. RANK signaling interferes with mammary cell commitment, contributing to breast carcinogenesis. PMID: 23766243
27. Enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK. PMID: 23954298
28. USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID: 23825189
29. Data show that cystatin C inhibits osteoclast differentiation and formation by interfering intracellularly with signaling pathways downstream RANK. PMID: 23572233
30. These results suggest that cell adhesion signaling regulates RANK expression in osteoclast precursors. PMID: 23139818
31. RANK signaling functionally contributes to key tumorigenic properties through a cell-autonomous homotypic mechanism PMID: 22421365
32. Recombinant fusion construct RANK-Fc has the potential to prevent coxsackievirus B3-induced ectopic calcification and bone loss in this mouse model. PMID: 23303667
33. Retrovirus-mediated shRNA targeting RANK inhibits osteoclast differentiation and osteolysis. PMID: 22913338
34. the increase in RANK-RANKL expression is a response to podocyte injury, and RANK-RANKL may be a novel receptor-ligand complex for the survival response during podocyte injury. PMID: 22848465
35. Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone. PMID: 22454522
36. CaMKII-RANK signaling interaction in the regulation of early osteoclastogenesis. PMID: 22428553
37. Data indicate that the RANK IVVY motif, plays a crucial role in IL-1-mediated osteoclastogenesis. PMID: 22416138
38. ablation of the RANKL-RANK pathway has no direct adverse effect on B cell physiology PMID: 22219325
39. demonstrated a Rank-mediated reciprocal link between dendritic epidermal T cell progenitors and Aire(+) medullary thymic epithelial cell maturation PMID: 22425250
40. that estrogens deficit is a strong stimulus for RANKLRANK/ OPG pathway that breaks an inhibitory influence of hypothyroidism even in IL-6 deficient mice. PMID: 21478097
41. RANK signaling induces interferon -stimulated gene expression in both type I interferon-independent and interferon-dependent mechanisms. PMID: 21527253
42. PPARgamma agonist inhibited the differentiation of RAW264.7 cells into osteoclasts by suppressing RANK. PMID: 21029677
43. vRANK is a novel osteoclast suppressor that reduces the number of RANKL-induced mature osteoclasts mainly by negating the anti-apoptotic effect of RANKL. PMID: 21153864
44. Estrogens modulate RANKL-RANK/osteoprotegerin mediated interleukin-6 effect on thyrotoxicosis-related bone turnover. PMID: 21332025
45. the LTbetaR signal exhibits a novel and unique function in promoting RANK activity for medullary thymic epithelial cell organization PMID: 21441458
46. Data suggest that RANK-RANKL regulates hair renewal and epidermal homeostasis and provides a link between these two activities. PMID: 21402940
47. Sbds is required for osteoclastogenesis by regulating monocyte migration via Rac2 and osteoclast differentiation signaling downstream of RANK. PMID: 21084708
48. RANKL and RANK are involved in mammary/breast cancer metastasis PMID: 21326202
49. These results indicate that IL-1 directly activates RANK signaling other than inducing RANKL to promote osteoclastogenesis and plays an important role in physiological bone metabolism. PMID: 20679512
50. IL-3 irreversibly inhibits RANK expression that results in inhibition of important signaling molecules induced by RANKL during osteoclastogenesis. PMID: 20691668

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KEGG: mmu:21934

STRING: 10090.ENSMUSP00000027559

UniGene: Mm.6251