ATG12 Antibody

Datasheet
Code CSB-RA002283A0HU
Size US$350
Uniprot No. O94817
Immunogen A synthesized peptide derived from human ATG12
Species Reactivity Human
Tested Applications ELISA
Relevance Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Ubiquitin-like protein ATG12, Autophagy-related protein 12, APG12-like, ATG12, APG12, APG12L
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cell Biology
Gene Names ATG12
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
Subcellular Location Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein
Protein Families ATG12 family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 588

OMIM: 609608

KEGG: hsa:9140

STRING: 9606.ENSP00000425107

UniGene: Hs.264482

Pathway Autophagy
NOD-like receptor signaling pathway
FoxO signaling pathway

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