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| Code | CSB-RA002283A0HU |
| Size | US$350 |
| Uniprot No. | O94817 |
| Immunogen | A synthesized peptide derived from human ATG12 |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Affinity-chromatography |
| Isotype | Rabbit IgG |
| Clonality | Monoclonal |
| Alias | Ubiquitin-like protein ATG12, Autophagy-related protein 12, APG12-like, ATG12, APG12, APG12L |
| Immunogen Species | Human |
| Protocols | ELISA Protocol |
| Research Area | Cell Biology |
| Gene Names | ATG12 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. |
| Subcellular Location | Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein |
| Protein Families | ATG12 family |
| Tissue Specificity | Ubiquitous. |
| Database Links |
HGNC: 588 OMIM: 609608 KEGG: hsa:9140 STRING: 9606.ENSP00000425107 UniGene: Hs.264482 |
| Pathway |
Autophagy
NOD-like receptor signaling pathway FoxO signaling pathway |
ATG12 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002283GA01HU | ATG12 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA313566 | ATG12 Antibody | Human | ELISA,IHC |
| CSB-PA065886 | ATG12 Antibody | Human | ELISA,IHC |
| CSB-PA002283XA01HU | ATG12 Antibody | Homo sapiens (Human) | ELISA, WB (ensure identification of antigen) |
ATG12 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002283HU CSB-EP002283HU CSB-BP002283HU CSB-MP002283HU |
Recombinant Human Ubiquitin-like protein ATG12(ATG12) | Yeast E.coli Baculovirus Mammalian cell |
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