Name: CD96 Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA004971A0HU

Product Details

Uniprot No.	P40200
Target Names	CD96
Alternative Names	CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
Species Reactivity	Human
Immunogen	Recombinant Human CD96 protein
Immunogen Species	Homo sapiens (Human)
Conjugate	Non-conjugated
Clonality	Monoclonal
Isotype	hIgG1
Purification Method	Affinity-chromatography
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Gene References into Functions	Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070 Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276 CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704 In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333 down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144 CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978 The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528 CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010 CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927 CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733 Show More Hide All
Involvement in disease	C syndrome (CSYN)
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
Database Links	HGNC: 16892 OMIM: 211750 KEGG: hsa:10225 STRING: 9606.ENSP00000283285 UniGene: Hs.142023

CloseMessage

Product >> Product Name：
Product >> Code：
Product >> Size：
Name： *
Email： *
Phone：
We recommend you to leave your phone number because occasionally our emails get flagged by spam filters. We would not disclose any of your private information to any third party.
Question/Comment： *
Your Region： *
Country State：
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
Check Code：

Code	CSB-RA004971A0HU
Size	US$350
Image	The Binding Activity of CD96 with anti-CD96 antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD96(CSB-MP004971HU1(F2)) at 2 μg/mL can bind Anti-CD96 recombinant antibody, the EC₅₀ is 95.78-127.1 ng/mL.
Have Questions?	Leave a Message or Start an on-line Chat

CD96 Monoclonal Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background

CloseMessage