CD96 Recombinant Monoclonal Antibody

Code CSB-RA004971A0HU
Size US$210
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  • The Binding Activity of CD96 with anti-CD96 antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD96(CSB-MP004971HU1(F2)) at 2 μg/mL can bind Anti-CD96 recombinant antibody, the EC50 is 95.78-127.1 ng/mL.
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Product Details

Uniprot No.
Target Names
Alternative Names
CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
Species Reactivity
Human
Immunogen
Recombinant Human CD96 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG1
Clone No.
4A4
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The process of generating the CD96 recombinant monoclonal antibody is complex and consists of several stages. Firstly, the CD96 monoclonal antibody is collected, and its gene sequence is analyzed. Next, a vector containing the CD96 monoclonal antibody gene is constructed and transfected into a host cell line for culturing. During the CD96 monoclonal antibody production, a recombinant human CD96 protein is used as an immunogen. The CD96 recombinant monoclonal antibody is then purified using affinity chromatography and assessed for specificity using ELISA applications. It can bind to the human CD96 protein (CSB-MP004971HU1(F2)) with the EC50 of 95.78-127.1 ng/mL. It only recognizes the human species.

CD96, also known as TACTILE, is a transmembrane protein expressed on the surface of a variety of immune cells, including natural killer (NK) cells, T cells, and dendritic cells. CD96 is involved in the regulation of immune cell activation and plays a role in the recognition and elimination of target cells, including tumor cells. CD96 can bind to its ligand CD155, which is expressed on the surface of tumor cells and other target cells. This interaction leads to the activation of immune cells and the initiation of an immune response against the target cells. CD96 has also been implicated in the regulation of immune cell migration and the development of immune cell memory.

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Target Background

Function
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Gene References into Functions
  1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
  2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
  3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
  4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
  5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
  6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
  7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
  8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
  9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
  10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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Involvement in disease
C syndrome (CSYN)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
Database Links

HGNC: 16892

OMIM: 211750

KEGG: hsa:10225

STRING: 9606.ENSP00000283285

UniGene: Hs.142023

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