CD96 Antibody

Code CSB-PA004971LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA004971LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA004971LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, HEK293 whole cell lysate
    All lanes: CD96 antibody at 2.5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 66, 64 kDa
    Observed band size: 66 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CD96 Polyclonal antibody
Uniprot No.
Target Names
CD96
Alternative Names
CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human T-cell surface protein tactile protein (306-395AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CD96 Antibody (Product code: CSB-PA004971LA01HU) is Non-conjugated. For CD96 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004971LB01HU CD96 Antibody, HRP conjugated ELISA
FITC CSB-PA004971LC01HU CD96 Antibody, FITC conjugated
Biotin CSB-PA004971LD01HU CD96 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The CD96 antibody production starts by inoculating a synthetic peptide corresponding to the 306-395 amino acids of the recombinant human T-cell surface protein tactile into a rabbit to induce an immune reaction. The resulting CD96 polyclonal antibody mixture is then subjected to protein G affinity chromatography purification. Its purity exceeds 95%. The purified CD96 antibody is finally tested for specificity and affinity in ELISA, WB, IHC, and IF applications, ensuring its ability to bind to the CD96 protein. It only reacts with human samples.

The CD96 protein, also known as T-cell surface protein tactile, modulates immune cell activation and regulation by interacting with its ligand, CD155. CD96 has also been implicated in the regulation of immune checkpoint pathways, such as the programmed cell death protein 1 (PD-1) pathway.

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Target Background

Function
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Gene References into Functions
  1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
  2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
  3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
  4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
  5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
  6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
  7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
  8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
  9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
  10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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Involvement in disease
C syndrome (CSYN)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
Database Links

HGNC: 16892

OMIM: 211750

KEGG: hsa:10225

STRING: 9606.ENSP00000283285

UniGene: Hs.142023

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