Name: CD96 Antibody, FITC conjugated
Brand: CUSABIO
SKU: CSB-PA004971LC01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) CD96 Polyclonal antibody
Uniprot No.	P40200
Target Names	CD96
Alternative Names	CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human T-cell surface protein tactile protein (306-395AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	FITC
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Gene References into Functions	Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070 Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276 CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704 In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333 down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144 CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978 The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528 CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010 CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927 CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733 Show More Hide All
Involvement in disease	C syndrome (CSYN)
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
Database Links	HGNC: 16892 OMIM: 211750 KEGG: hsa:10225 STRING: 9606.ENSP00000283285 UniGene: Hs.142023

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CD96 Antibody, FITC conjugated

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Code	CSB-PA004971LC01HU
Size	US$299
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