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MYL9 Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA015318MA1HU
Size US$210
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  • The Binding Activity of Human MYL9 with Anti-MYL9 recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL9 (CSB-YP015318HU) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 4.628-6.430 ng/mL.
  • The Binding Activity of Human MYL12B with Anti-MYL9 recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12B (CSB-EP015308HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 7.760-8.646 ng/mL.
  • The Binding Activity of Human MYL12A with Anti-MYL9 recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12A (CSB-EP015307HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 5.325-6.456 ng/mL.
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Product Details

Uniprot No.
P24844
Target Names
MYL9
Alternative Names
MYL9 Recombinant Monoclonal Antibody
Species Reactivity
Human
Immunogen
Recombinant Human MYL9 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG2
Clone No.
6G11
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

To generate the MYL9 recombinant monoclonal antibody, the MYL9 antibody genes were initially integrated into plasmid vectors. These engineered plasmid vectors were subsequently introduced into suitable host cells utilizing exogenous protein expression techniques to facilitate antibody production. Subsequent to this production phase, the MYL9 recombinant monoclonal antibody underwent purification via affinity chromatography. This antibody is suitable for ELISA. In the functional ELISA, it was established that the MYL9 recombinant monoclonal antibody demonstrated robust binding to the human MYL9 protein (CSB-YP015318HU) at a concentration of 2 μg/mL, displaying an EC50 within the range of 4.628 to 6.430 ng/mL.

MYL9 is a versatile protein that functions as a regulatory subunit of myosin II in both muscle and non-muscle cells. Its main roles include regulating muscle contraction, controlling cell motility, and participating in various cellular processes associated with changes in cell shape and movement. The phosphorylation of MYL9 and its interactions with other proteins are central to its functions in these processes.

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Target Background

Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
Gene References into Functions
  1. MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
  2. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
  3. These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
  4. the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
  5. Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
  6. Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
  7. surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
  8. The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
  9. Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
  10. use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058

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Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Tissue Specificity
Smooth muscle tissues and in some, but not all, nonmuscle cells.
Database Links

HGNC: 15754

OMIM: 609905

KEGG: hsa:10398

STRING: 9606.ENSP00000279022

UniGene: Hs.504687

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Related pathways
cAMP signaling pathway Focal adhesion Regulation of actin cytoskeleton Vascular smooth muscle contraction Leukocyte transendothelial migration cGMP-PKG signaling pathway Target Therapy
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