Code | CSB-RA007511A446phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
CUSABIO cloned the DNA sequence encoding the phospho-EIF2AK2 (T446) monoclonal antibody into the plasmid and then transfected into the cell line for expression. The product is the recombinant phospho-EIF2AK2 (T446) monoclonal antibody. It belongs to the rabbit IgG and is purified through the affinity-chromatography method. This EIF2AK2-pT446 antibody has been quality tested in ELISA, WB, IHC, and IF. It can recognize the human EIF2AK2 phosphorylated at Thr446 residue.
EIF2AK2, also known as PKR, plays an important role in the antiviral defense and cellular homeostasis by modulating mRNA translation. It detects dsRNA molecules produced during DNA and RNA virus replication and mounts a powerful antiviral response by inhibiting viral mRNA translation, causing infected cells to die. PKR is activated by the homodimerization and subsequent autophosphorylation on Thr446 and Thr451 after binding dsRNA.
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