Code | CSB-EP007511HU |
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Size | $224 |
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Full-length of mature human interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2 cDNA carrying an N-terminal 6xHis-SUMO-tag was expressed in E.coli. The resulting protein is the recombinant fusion protein consisting of 2-551aa of human EIF2AK2. It was validated by both SDS-PAGE and LC-MS/MS analyses. The SDS-PAGE showed an about 75-85 kDa molecular mass of this protein and determines the purity of over 90%. In addition to being an immunogen for specific antibody synthesis, this recombinant protein also may be used in the studies of EIF2AK2-mediated signal transduction.
EIF2AK2, also called PKR, is activated by double-stranded RNA (dsRNA) and blocks the translation of viral mRNA in response to infection and physiologic stress conditions. It is also involved in innate immune response and the modulation of signal transduction, apoptosis, cell proliferation, and differentiation. Dongxue Mao etc. demonstrated that EIF2AK2 missense variants lead to a neurodevelopmental syndrome that may share phenotypic and pathogenic mechanisms with childhood ataxia with central nervous system hypomyelination/vanishing white matter disease (CACH/VWM).
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