Recombinant Mouse High affinity immunoglobulin epsilon receptor subunit alpha(Fcer1a)-VLPs

1. House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcepsilonRIalpha. PMID: 28700253
2. this study shows that mast cells co-cultured with macrophages alter protein expression of both cell types, and that mast cells transfer FceRI-encompassed cellular regions directly to macrophages during Francisella tularensis PMID: 27554051
3. Tim-3 acts at a receptor-proximal point to enhance Lyn kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI ligation. PMID: 26598760
4. Conferring expression of FcepsilonRI to dendritic cells decreases the severity of food allergy and asthma in disease-relevant models suggesting anti-inflammatory IgE/FcepsilonRI signals. PMID: 25227985
5. IgE-mediated activation of dendritic cells via IgE receptors binding in allergic Th2-type inflammation appears to be immune regulatory rather than pro-inflammatory. (Review) PMID: 26052071
6. Specific cross-linking of the high affinity immunoglobulin epsilon receptor on the surface of bone marrow-derived mast cells and heart mast cells elicits the release of enzymatically active renin protein. PMID: 24262755
7. Zinc-binding MT1 and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4. PMID: 25801306
8. Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI. PMID: 25422497
9. IgE-mediated allergic hypersensitivity provokes release of renin from both cultured and resident cardiac mast cells. PMID: 24262755
10. Overexpression of miR-142-3p enhances FcepsilonRI-mediated degranulation. PMID: 24361879
11. OX40L engagement impairs FcepsilonRI activation and Gab2/PI3K/Akt, but not Syk/LAT, phosphorylation PMID: 22564682
12. FcepsilonRI, but not FcgammaR, signals induce prostaglandin D2 and E2 production from basophils PMID: 21712025
13. data implicate Fyn as the major positive mediator of STAT5 after FcepsilonRI engagement and demonstrate importantly distinct roles for STAT5A and STAT5B in mast cell function. PMID: 22130676
14. Reduced IgE/antigen-mediated passive cutaneous anaphylaxis is detected in mice with Piga-deficient mast cells. PMID: 21865342
15. The PI3K binding site is involved in FcepsilonRI-dependent ARF1 activation and granule translocation to the plasma membrane in the degranulation process, further dissecting the signals required for degranulation. PMID: 21653832
16. Whereas FcepsilonRI required Lyn and Syk for NTAL phosphorylation, Kit appeared to directly phosphorylate NTAL. PMID: 17993265
17. This is the first observation to attribute a spatiotemporally restricted antigen-presenting function to a subset of three-week old pure BMMC expressing both high levels of surface FcepsilonRI and surface major histocompatibility complex II. PMID: 20591187
18. Peripheral blood basophils express approximately 50% of the Fc epsilon RI density of bone marrow (BM) basophils. A 3-fold greater synthetic rate of Fc epsilon RI on BM basophils readily explains the difference. PMID: 20042574
19. Fc epsilon RI-mediated calcium flux (dependent on PLC gamma 1) leads to degranulation of mast cells independent of PI 3-kinase PMID: 13129935
20. FcepsilonRI stimulation triggers the formation of microtubules in a manner independent of calcium. Drugs affecting microtubule dynamics effectively suppressed the FcepsilonRI-mediated translocation of granules to the plasma membrane and degranulation. PMID: 15998803
21. SHIP and Src homology 2 domain-containing protein tyrosine phosphatase-1 interacted with FcepsilonRI beta, and their phosphorylation was controlled by Lyn. PMID: 16272347
22. Fc receptor gamma RI interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI PMID: 16627486
23. The length of the stalk region of the alpha-chain is an important determinant of Fc epsilon receptor IA stability on the cell surface. PMID: 16709862
24. IL-33 prolonged mast cell survival in the absence of IgE and impaired survival in the presence of SPE-7 IgE. PMID: 17881510
25. These findings show that the extracellular domain of the type I transmembrane protein Fc epsilon RI alpha plays a role in Fc epsilon RI intracellular processing and expression at the cell surface. PMID: 18179824
26. the high affinity of IgE for FcepsilonRI is critical to the allergic response, and that even moderate attenuation of this affinity has a substantial effect in vivo PMID: 18703499
27. positive and negative regulators of FcepsilonRI have roles in mast cell activation [review] PMID: 19082920
28. autoantibodies against Fcer1a is present in 30-50% urticaria patients PMID: 19331714
29. Fc(epsilon)RIand CD16 thus contribute to atopic dermatitis but differentially regulate immune responses associated with the disease. PMID: 19414806
30. the role of PI3Kgamma on the Fc epsilon RI mediated mast cell migration. PMID: 19494508
31. Data suggest that PTPepsilon negatively regulates FcepsilonRI-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions. PMID: 19508371

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KEGG: mmu:14125

STRING: 10090.ENSMUSP00000056882

UniGene: Mm.5266