Fc epsilon RI signaling pathway

Fc epsilon RI controls the activation of mast cells and basophils, and participates in IgE-mediated antigen presentation. Activated mast cells release preformed granules which contain proteoglycans (especially heparin) and biogenic amines (especially histamines). Fc epsilon RI signaling pathways in mast cells are initiated by the combination of the extracellular domain of the alpha chain of Fc epsilon RI and the Fc region of antigen-specific immunoglobulin E (IgE). After Fc epsilon RI aggregation by antigen-induced-crosslinking the immunoglobulin E, beta-subunit-associated LYN is activated and phosphorylates immuno-receptor tyrosine-based activation motifs (ITAMs) in the beta and gamma subunits of Fc epsilon RI. Phosphorylated ITAMs of the beta- and gamma- subunits recruit additional molecules of LYN and SYK. SYK binding to the Fc epsilon RI complex is activated through conformational changes after tyrosine phosphorylation by LYN. Additionally, Fc epsilon RI is the central to the induction and maintenance of an allergic response and may confer physiological protection in parasitic infections. Moreover, this receptor induces multiple signaling pathways that control the secretion of allergic mediators and induction of cytokine gene transcription, resulting in secretion of molecules such as Interleukins: IL-4, IL-5, IL-6, IL-10, IL-13, INF-Gamma, TNF-Alpha and GCSF.

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