Sphingolipids are a kind of amphiprotic lipids containing sphingol backbones, which attach to a long chain of fatty acids at one end and polar alcohol at the other. Sphingolipids, including sphingomyelins, cerebrosides, and gangliosides, are commonly found in plant and animal membranes and are particularly abundant in tissues of the central nervous system. Cerebrosides and gangliosides can also be called glycosphingolipids due to their glycosyls.
In mammals, the sphingolipid signaling pathway refers to the process by which ceramide (Cer) and sphingosine-1-phosphate (S1P), the hydrolytic products of sphingolipid, functions in a variety of cellular signaling pathways.
Sphingolipids and their metabolites are important active molecules involved in many important signal transduction processes such as cell proliferation, differentiation, senescence, and apoptosis.
In mammals, membrane sphingomyelin is hydrolyzed into ceramide and S1P by sphingomyelinase (SMase). Ceramide subsequently generates sphingosine (Sph) by ceramidase. Sphingosine produces S1P through phosphorylation by sphingosine kinases 1 (SphK1) and sphingosine kinases 2 (SphK2). Although both ceramide and S1P regulate cellular responses to stress, they function oppositely. S1P acts as a survival factor and a ligand for a family of G protein-coupled receptors, whereas ceramide activates intrinsic and extrinsic apoptotic pathways through receptor-independent mechanisms.
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|ADORA1||ADORA1 Antibody||ADORA1 Protein||ADORA1 ELISA Kit|
|ADORA3||ADORA3 Antibody||ADORA3 Protein||ADORA3 ELISA Kit|
|BDKRB2||BDKRB2 Antibody||BDKRB2 Protein||BDKRB2 ELISA Kit|
|FCER1A||FCER1A Antibody||FCER1A Protein||FCER1A ELISA Kit|
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|GAB2||GAB2 Antibody||GAB2 Protein||GAB2 ELISA Kit|
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|GNA13||GNA13 Antibody||GNA13 Protein||GNA13 ELISA Kit|
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|GNAI2||GNAI2 Antibody||GNAI2 Protein||GNAI2 ELISA Kit|
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|HRAS||HRAS Antibody||HRAS Protein||HRAS ELISA Kit|
|KRAS||KRAS Antibody||KRAS Protein||KRAS ELISA Kit|
|MAP2K1||MAP2K1 Antibody||MAP2K1 Protein||MAP2K1 ELISA Kit|
|MAP2K2||MAP2K2 Antibody||MAP2K2 Protein||MAP2K2 ELISA Kit|
|MAPK1||MAPK1 Antibody||MAPK1 Protein||MAPK1 ELISA Kit|
|MAPK3||MAPK3 Antibody||MAPK3 Protein||MAPK3 ELISA Kit|