Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b)

Code CSB-CF023978MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Tnfrsf1b
Uniprot No.
Alternative Names
Tnfrsf1b; Tnfr-2; Tnfr2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD antigen CD120b
Species
Mus musculus (Mouse)
Expression Region
23-474
Target Protein Sequence
VPAQVVLTPYKPEPGYECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVCADCEASMYTQVWNQFRTCLSCSSSCTTDQVEIRACTKQQNRVCACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLCKACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEPTRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGISLPIGLIVGVTSLGLLMLGLVNCIILVQRKKKPSCLQRDAKVPHVPDEKSQDAVGLEQQHLLTTAPSSSSSSLESSASAGDRRAPPGGHPQARVMAEAQGFQEARASSRISDSSHGSHGTHVNVTCIVNVCSSSDHSSQCSSQASATVGDPDAKPSASPKDEQVPFSQEECPSQSPCETTETLQSHEKPLPLGVPDMGMKPSQAGWFDQIAVKVA
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Gene References into Functions
  1. MPTP induced TNF-alpha signaling through TNFR2 mediated pathway and recruited p65-p52 dimer in hippocampal nucleus which is reported to have protective effect on hippocampal neurons indicated by unchanged neuronal count in hippocampus in treated groups with respect to control. PMID: 29481885
  2. study reports an important role for TNFR2 on low-affinity-primed secondary effector CD8+ T cells; results demonstrate the importance of TNF signaling in low-affinity, cross-reactive CD8+ T cell responses during heterologous immunity PMID: 27481849
  3. our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver PMID: 26483205
  4. TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice. PMID: 26475926
  5. TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8(+) T cells. PMID: 26072395
  6. To determine the role of TNF-TNFR2/p75 signaling in ischemia-induced inflammation and muscle regeneration, we subjected wild-type and TNFR2/p75 knockouts to hind limb ischemia. PMID: 25466901
  7. Results demonstrate novel roles of TNFRII in the regulation of Abeta production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII levels and elevating phosphorylated IkappaBalpha by SUMOylation. PMID: 24824215
  8. PGRN protection of endoplasmic reticulum stress induced apoptosis was abolished when TNFR2 signaling was blocked. PMID: 24703938
  9. TNFR2 signaling by itself is both sufficient and required to induce Vbeta5+ Treg expansion. PMID: 25098294
  10. TNF-alpha produced by alveolar macrophages induces Th2 cell response, via TNFR2 on Natural killer T cells. PMID: 24191851
  11. both young and aged mice deficient of TNFR2 performed poorly in the contextual fear conditioning test and displayed decreased anxiety-like behavior PMID: 24135018
  12. Mice lacking TNFRp75 exhibit greater control of M. tuberculosis infection compared with WT mice. TNFRp75-/- mice developed effective bactericidal granulomas and demonstrated increased pulmonary recruitment of activated dendritic cells. PMID: 24569452
  13. TNFR2 deficiency significantly impaired transmembrane TNF-alpha-induced release of IL-10 and NO and inhibition of T cell proliferation by MDSC supernatant. TNF-alpha acts as a potent activator of MDSCs via TNFR2 and promotes tumor immune escape. PMID: 24379122
  14. Our results indicate that TNFR2 signaling is required for the innate airway hyperresponsiveness that develops in obese mice, and suggest that TNFR2 may act by promoting IL-17A, endothelin, and/or trkB expression. PMID: 22584291
  15. In immune-mediated inflammatory bowel disease models, TNFR2 signaling increases long MLCK expression, resulting in tight junction dysregulation, barrier loss, and induction of colitis. PMID: 23619146
  16. High Soluble TNFR2 is associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction PMID: 23405158
  17. We propose a novel mechanism in which TNF activates TNFR2 on Treg cells and thereby expands this immunosuppressive immune cell population. PMID: 23385062
  18. In a chronic model of proliferative nephritis, IRF1 and renal-expressed TNFR2 were essential for sustained macrophage accumulation. PMID: 23623383
  19. Lipopolysaccharide-induced pulmonary alveolar inflammation upregulates alveolar macrophage-mediated production of sTNFR p75. Mechanical ventilator-induced lung injury enhances alveolar epithelial permeability leading to increased sTNFRp75. PMID: 21512145
  20. results suggest that TNFR2 expressed on podocytes and its canonical NF-kappaB signaling may directly interpose the compound pathogenic responses by podocytes to TNF-alpha, in the absence of other TNFR2-positive renal cell types in proliferative podocytopathies PMID: 21221075
  21. p75 is essential for tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts. PMID: 22158049
  22. Both internalization and ASK1-interacting protein-1 association are required for TNFR2-dependent JNK and apoptotic signaling in endothelial cells. PMID: 22743059
  23. this suggests that the protective effect seen in mice lacking TNFR2 results rather from environment-induced attenuation by low dose bacterial endotoxins than from missing pro-inflammatory signalling via the TNFR2. PMID: 22449555
  24. TNF-alpha signaling through TNFR2 is essentially involved in the bile acid synthesis and excretion of lipids, resulting in its beneficial effects. PMID: 21850461
  25. co-activation of TNFR2 during beta-AR stress is anti-inflammatory and counterbalances pro-inflammatory, pro-hypertrophic effects of unopposed TNFR1 activation PMID: 21691899
  26. expression on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE PMID: 22105853
  27. TNFR1, not TNFR2, mediates TNF-alpha stimulation of dendritic cell maturation and CD8 T cell response to recombinant mouse hepatitis virus infection in vivo. PMID: 21709152
  28. requirement for TNFR2-expression on murine natural Tregs (nTregs) and induced Tregs (iTregs) in mediating suppression of colitis PMID: 21572024
  29. These results provide the first in vivo evidence for the origin and regulation of soluble TNFR2 in serum. PMID: 21258364
  30. TR2 is an important mediator in colitis, and may serve as a therapeutic target in inflammatory bowel disease. PMID: 21347711
  31. Tumor necrosis factor-alpha signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium PMID: 21153348
  32. Mesenchymal stem cell TNFR2 plays an important role in MSC-mediated cardiac protection after myocardial ischemia. PMID: 20160664
  33. critical for developing macrophages that control of T-cell proliferation PMID: 20518824
  34. These data indicate that, through TNFR2, microglia may contribute to the counter-regulatory response activated in neuropathological conditions. PMID: 20600925
  35. These data suggest a protective role for TNFR2/Fas in the pathogenesis of traumatic brain injury. PMID: 20205514
  36. Intratumoral Tregs expressing more TNFR2 are able to overcome the greater resistance to suppression of intratumoral conventional T cells, resulting in a dominant immunosuppressive tumor environment. PMID: 20525892
  37. Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. PMID: 20139367
  38. TNFR2(KO) myocardium showed little Etk activation and cell cycle entry but increased ASK1 activation and apoptosis. PMID: 19788501
  39. TNF type 2 receptor (p75) lowers the threshold of T cell activation PMID: 11739497
  40. Interaction of TNFR2 with TNF is important in the pathogenesis of wasting associated with acute graft-versus-host-disease (GVHD)and in the generation of histopathological lesions of intestinal GVHD. PMID: 11884480
  41. CD120b signaling is required for optimal CD40-induced IgM secretion by B cells. PMID: 11907088
  42. Review. Blockade of the p75TNFR may be helpful in treating systemic autoimmunity since its function may be essential for systemic tissue damage. PMID: 12220546
  43. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. PMID: 12228317
  44. p75 TNF-alpha receptor 2 is required for the regulation of airway hyperresponsiveness (AHR) by gamma delta T cells, since p75-deficient mice develop AHR to a similar degree as control mice following sensitization and challenge with allergen. PMID: 12370348
  45. TNFRs within the CNS play a significant role in shaping the outcome of TNF signaling during neuroimmune interactions. PMID: 12522266
  46. Role differs fom that of p55TNFR in the induction of PAI-1. PMID: 12598326
  47. LPS triggers a rapid shedding of CD120b via a protein kinase C- and Src-independent pathway mediated by p38 MAPK, furin, and metalloproteinase. PMID: 12663667
  48. TNF/TNFR2 interactions facilitate generation of FasL-dependent CTL effector pathways that play an important role in in vivo antiviral-immune responses in the liver. PMID: 12960267
  49. Skin tumour multiplicity was significantly reduced in TNFR1-/- and TNFR2-/- mice compared to wild-type mice. PMID: 14661063
  50. Impaired induction of major histocompatibility complex class I glycoproteins in TNF-R2-deficient mice following axotomy of facial motor nucleus underscores the central role of TNF in the immune activation of the injured nervous system. PMID: 14961564

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Subcellular Location
Membrane; Single-pass type I membrane protein.
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