Recombinant Human C-C motif chemokine 17 protein(CCL17) (Active)

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Code CSB-AP000611HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
Target Names CCL17
Uniprot No. Q92583
Research Area Immunology
Alternative Names A-152E5.3; A152E53; ABCD 2; ABCD2; C-C motif chemokine 17; CC chemokine TARC; CCL17; CCL17_HUMAN; Chemokine CC Motif Ligand 17; MGC138271; MGC138273; SCYA17; Small Inducible Cytokine A17; Small Inducible Cytokine A17 Precursor; Small Inducible Cytokine Subfamily A (Cys Cys); Small Inducible Cytokine Subfamily A (Cys Cys) Member 17; Small-inducible cytokine A17; T Cell Directed CC Chemokine; Thymus and activation regulated chemokine ; Thymus and activation-regulated chemokine
Species Homo sapiens (Human)
Source E.coli
Expression Region 24-94aa
Complete Sequence ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S
Mol. Weight 8.1 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 20mM PB, pH 7.4, 150mM NaCl
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Gene References into Functions
  1. The frequency of the CC genotype in the TARC rs223828 SNP was higher in patients with intractable Graves disease than in patients with Graves disease in remission. PMID: 29848886
  2. The expression of CCL17 was decreased in nasal polyp (NP) epithelium compared to the epithelium of normal ethmoid sinus, whereas the expression of CCL22 was not decreased. E-cadherin was differentially distributed between the epithelium of normal ethmoid sinus and NP epithelium. EGFR was also decreased in NPs. PMID: 29746583
  3. TARC serum levels were elevated in 78% of sarcoidosis patients and correlated with disease severity. PMID: 29598931
  4. Serum TARC level may be a potent marker reflecting better response to IL-17A inhibitors for psoriasis treatment. PMID: 29655215
  5. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review] PMID: 29099057
  6. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 production in ectopic milieu. The high levels of IL-6 in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK signal pathway, and then, CCL17 further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 production via NF-kappaB activation. PMID: 28240436
  7. Data suggest that high levels of CCL17 and CCL22 in endometrium in women with endometriosis promote (1) recruitment of Tregs, (2) immunosuppression of Tregs, and (3) angiogenesis in endometrium. (Tregs = regulatory T cells) PMID: 28383711
  8. Serum TARC levels correlate well with indicators of systemic inflammation and of disease severity among patients with a drug eruption except SJS/TEN. Serum TARC may be a prognostic biomarker of severity of inflammation in drug eruptions. PMID: 28648978
  9. TARC production in HaCaT keratinocytes through the interaction between IL-22 and IL-22Ralpha facilitates T-cell migration in atopic dermatitis caused by house dust mites. PMID: 26914146
  10. TARC is a candidate biomarker for PTSD only in males. PMID: 28170001
  11. High CCL17 expression is associated with colon cancer cell migration. PMID: 28146427
  12. GM-CSF can mediate inflammation and pain by regulating IRF4-induced CCL17 production PMID: 27525438
  13. Based on the ADEPT study data set, we report that airway mucosal expression of CCL26 was a robust discriminator of type 2 inflammation from healthy nonatopic subjects. Furthermore, airway mucosal CCL26 expression was best identified by using a panel of clinical biomarkers, including Feno values, bEOS counts, and expression of 2 novel markers, sCCL17 and sCCL26 PMID: 28089872
  14. Low CCL17 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with clear cell renal cell carcinoma after nephrectomy. PMID: 28178948
  15. IP-10 serum increase or TARC/IP-10 ratio decrease along with abnormal hepatic enzymatic alteration could signify early rejection of the transplanted liver. PMID: 28245475
  16. elevated pre-treatment levels of sGal-1, sCD163, sCD30 and TARC can be found in patients with classic Hodgkin lymphoma. However, only plasma TARC accurately reflects disease activity and correlates with clinical treatment response. PMID: 27610595
  17. levels elevated in rheumatoid arthritis synovial fluid, due to production by mononuclear cells, particularly CD1c classical dendritic cells PMID: 27250804
  18. Serum TARC levels are well correlated with blood eosinophil counts in patients with generalized drug eruptions, indicating that Th2-type immune reactions underlie TARC production. Serum TARC measurements also have potent diagnostic value for DIHS, with high sensitivity and specificity. PMID: 27497618
  19. Data suggest that Th1 (IFN-gamma-inducible protein-10 IP-10/CXCL10) and Th2 (thymus and activation regulated chemokine TARC/CCL17) and (macrophage derived chemokine MDC/CCL22) cooperatively play a role in the development of ankylosing spondylitis (AS). PMID: 26827189
  20. CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma.Higher levels of intratumoral CCL17 expression are associated with poorer survival of hepatocellular carcinoma patients. PMID: 26781124
  21. CCL17 and CCL18 dermal expression is associated with leprosy polarity. PMID: 25412496
  22. The SNP rs223895 in TARC/CCL17 gene is associated with the susceptibility to Kawasaki disease. PMID: 26182268
  23. Serum CCL17 levels are associated with coronary artery disease and atherosclerosis severity independently of traditional cardiovascular risk factors. PMID: 25555269
  24. TARC was correlated with disease status and its monitoring may be able to predict PET positivity after alloSCT, thus potentially allowing an early immune manipulation. PMID: 25240818
  25. Serum levels of CCL17 were positively correlated with coronary artery disease. PMID: 25062565
  26. increased expression in the thymus of myasthenia gravis patients PMID: 24397961
  27. TARC and interleukin-31 may be biomarkers for adult atopic dermatitis PMID: 24984931
  28. Serum TARC is a promising biomarker for remission and can be used for accurately monitoring proactive treatment for long-term control. [revew] PMID: 24628072
  29. disease activity and response biomarker in alopecia areata PMID: 24102731
  30. High CXCL10 levels were detected in acutely infected children regardless of virus pathogen, whereas increased CCL17 production was RSV-specific PMID: 25013801
  31. Higher serum concentrations of CCL17 at baseline may be predictive of acute exacerbations in patients with chronic hypersensitivity pneumonitis PMID: 23705860
  32. might be potential marker of non-eosinophilic oesophagitis gastrointestinal food allergies PMID: 24698291
  33. Serum TARC may represent a suitable biomarker for monitoring of atopic dermatitis severity in daily practice. PMID: 25199679
  34. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD. PMID: 24104601
  35. we found that TARC is an easily measured biomarker that is associated with faster TTR, longer PFS, and possibly longer OS in a population of patients with HL who were treated with panobinostat. PMID: 23822537
  36. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD PMID: 25268342
  37. CCL17 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. PMID: 12949249
  38. An association between TARC/CCL17 polymorphisms, susceptibility of Kawasaki disease, and intravenous immunoglobulin responses in Kawasaki disease patients. PMID: 23942559
  39. Migration assays were performed to evaluate CCL17-induced colon cancer cell (HT-29) chemotaxis and RhoA protein levels were quantified. PMID: 24582560
  40. Ginseng inhibited TARC expression via blockade of NF-kappaB activation in HaCaT cells. PMID: 23454147
  41. CCL17-induced, CCR4-dependent release of CGRP by human airway epithelial cells represents a novel inflammatory pathway in patients with asthma and allergic disease. PMID: 23731651
  42. These data reveal an elevated serum concentration of Th2-attracting chemokines CCL22 and CCL17 in opsoclonus-myoclonus syndrome. PMID: 23340773
  43. Autistic children had significantly higher serum levels of TARC than healthy controls PMID: 23782855
  44. Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma. PMID: 23224400
  45. Data suggest an important role for serum CCL17 level as biomarker of drug resistance/remission induction in Hodgkin lymphoma in response to various combined neoplastic agent protocols. PMID: 23225085
  46. increased expression in macrophages from asthmatic patients PMID: 22981793
  47. Data show that PD-1, PD-L1, PD-L2, CCL17, and CCL22 mRNA was identified in papillomas. PMID: 22322668
  48. Serum concentrations of TARC and CTACK were significantly higher in AD (atopic dermatitis) children than in healthy controls, and correlated with severity of symptoms. PMID: 22017510
  49. Baseline plasma thymus and activation-regulated chemokine levels correlate with classical Hodgkin's lymphoma tumor burden and serial levels correlate with response to treatment in patients with classical Hodgkin's lymphoma. PMID: 22058214
  50. PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation PMID: 22533972
  51. expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis and acute allergic contact dermatitis induced in nickel-sensitive individuals PMID: 21707761
  52. Contact between monocyte-derived dendritic cells and HCV-JFH1-infected Huh7 cells induced the expression of CCL17 and CCL22. PMID: 21129807
  53. these results indicated that serum TARC level may be a useful new serum marker for active interstitial lung disease in dermatomyositis. PMID: 20800454
  54. Startum corneum TARC was correlated with the severity of local skin lesions, especially with the erythema, edema/papule, and oozing/crusts score. PMID: 20374230
  55. These results indicate that intracellular reactive oxygen species and MAPK kinases both contribute to IFN-gamma-stimulated production of TARC and CCL22 by increasing NF-kappaB activation. PMID: 20625996
  56. CCL17 may contribute to Churg-Strauss syndrome pathogenesis by recruitment of Th2 cells into affected tissue. PMID: 20669282
  57. CCL17 and CCL22 within the tumor are related to the increased population of Foxp3(+) T-regs in esophageal squamous cell carcinoma. PMID: 20002703
  58. increase in serum levels is associated with progression-free survival in advanced melanoma patients in response to dendritic cell-based immunotherapy PMID: 19421847
  59. we have demonstrated that the normal serum level of TARC/CCL17 is significantly higher in early infancy, and established age specific levels in atopic dermatitis. PMID: 19236603
  60. Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies PMID: 12104083
  61. TARC may contribute to the pathogenesis of eosinophilic pleural effusions in paragonimiasis. PMID: 12390321
  62. TGF-beta(1) might regulate the TARC-related inflammatory processes, which may be important for understanding the pathogenesis of allergic diseases. PMID: 12413771
  63. modulation by IL-4 PMID: 12441140
  64. TARC was found to be highly expressed in the basal epidermis of the lesional skin of atopic dermatitis patients and only slightly in the non-lesional skin. PMID: 12456591
  65. Production of TARC by HaCaT cells is phenomenon specific to cell line, and observation on TARC in HaCaT cells can not be generalized. Normal human epidermal keratinocytes do not produce TARC protein in vitro. PMID: 12615362
  66. TGF-beta1 inhibited IFN-gamma and TNF-alpha-induced TARC production in HaCaT cells via Smad2/3. Modulation of TGF-beta/Smad signaling pathway may be beneficial for treatment of atopic dermatitis. PMID: 12615364
  67. The combination of TNF-alpha with either IL-4 or IL-13 markedly increased both TARC release and the abundance of TARC mRNA in corneal and dermal fibroblasts, but not in lung fibroblasts. PMID: 12642832
  68. important role in the production of antigen specific IgE by T-B cell interaction and in the pathogenesis of atopic dermatitis PMID: 12715916
  69. Th2 cytokines enhance TARC expression in human airway smooth muscle cells in IL-4Ralpha genotype-dependent fashion. PMID: 12871855
  70. The development of SLE is closely related to the elevation of plasma TARC/CCL17 levels. PMID: 14677179
  71. Basal expression and colocalization of CCL17 with E-selectin and ICAM-1 in dermal blood vessels serves to recruit T cells to noninflamed human skin and provides a strong cutaneous immunosurveillance system and model interface with the environment. PMID: 14734737
  72. selectively induced in EBV-infected B cells by LMP-1 protein PMID: 14747532
  73. serum levels correlate with disease severity specific for atopic dermatitis PMID: 14767451
  74. IL-4/IL-13 and IFN-gamma induce alternations in the distribution of adherens junctions in a different fashion and thereby contribute to the reciprocal regulation of TARC/MDC production. PMID: 14962085
  75. EBV infection induces TARC expression in B cells; EBNA-LP is one of the viral gene products responsible for the induction. PMID: 15047814
  76. Serum levels of TARC and MDC in atopic dermatitis patients were significantly higher than those found in normal controls PMID: 15113590
  77. primary Th2-dominated inflammatory reaction in atopic dermatitis induced by TARC leads to an augmented skin-specific inflammatory reaction through CTACK. PMID: 15335355
  78. IL-4 and IL-13 secreted from embryo during implantation may up-regulate TARC by endometrial epithelial cells. Production of TARC in endometrium may contribute to modulation of immune reaction by regulation of Th2 lymphocyte trafficking and functions. PMID: 15474066
  79. the -431C>T SNP of the TARC gene enhances the promoter activity of TARC gene but is not associated with susceptibility to AD in Japanese population PMID: 15500644
  80. findings indicate TARC and MDC are actively involved in pathogenesis of atopic dermatitis and their expression, opposite to that of eotaxin, is strongly associated with clinical picture of atopic dermatitis. PMID: 15813816
  81. Elevated bronchial mucosal expression of TARC/CCL17 is implicated in asthma pathogenesis; its action is partly through selective development and retention, or recruitment of T helper type 2, not Th1, receptor-bearing cells. PMID: 15944327
  82. CCR4 and TARC/CCL17 play role in pathophysiology of cutaneous lupus erythematosus(CLE). Cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE. PMID: 15955100
  83. Both a Th1 chemoattractant (CXCL9) and Th2 chemoattractants, CCL17 and CCL22, cooperatively play a role in the development of autoimmune blistering disease. PMID: 16583210
  84. Thymus and activation-regulated chemokine (TARC)/CCL17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts (review). PMID: 16859899
  85. The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined. PMID: 17023689
  86. Ragweed stimulation significantly increased the production of the Th2-associated cytokines IL-5, IL-9 and IL-13, the chemokines CCL17 and CCL22 and the regulatory cytokine IL-10 in allergic patients PMID: 17517104
  87. Bexarotene decreases chemotaxis to CCL17. PMID: 17546636
  88. Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC. PMID: 17548604
  89. Circulating TARC/CCL17 and KL-6 are useful measurements for discriminating acute eosinophilic pneumonia from other causes of acute lung injury. PMID: 17565019
  90. In a lung epithelial tumor cell model, respiratory syncytial virus induces the chemokine TARC that has a potential to recruit T helper type 2 (Th2) cells to the lung. PMID: 17641031
  91. thymus- and activation-regulated chemokine may have a role in bronchopulmonary aspergillosis in cystic fibrosis patients PMID: 17898016
  92. There were no significant differences in CCL17 and CCL22 expression in PBMCs, sera and lesional skins of patients with intrinsic and extrinsic atopic dermatitis. PMID: 17979978
  93. Via TARC production, nasal fibroblasts may play an important role in the recruitment of Th2 cells into the sinus mucosa as well as nasal polyps. PMID: 18004070
  94. evidence provided that a distal tandem STAT6 element elevates expression from the CCL17 locus approximately twofold. PMID: 18191727
  95. Significantly higher CCL17 expression is associated with gastric cancer PMID: 18224687
  96. Serum concentrations of CCL17, CCL22, and CCL27 correlate well with the extent and intensity of Atopic dermatitis (AD) in infants. Of the three Th2 chemokines examined, serum CCL27 correlated most significantly with the severity of AD PMID: 18266834
  97. Latent membrane protein 1-expressing tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder were selectively positive for CCL17 and CCL22. PMID: 18271928
  98. We investigated whether nasal polyp fibroblasts produce TARC when stimulated with the breakdown products of microorganisms (TLR ligands) and a Th2 cytokine (IL-4). PMID: 18375080
  99. TARC overexpression is associated with eosinophilia in T-cell lymphomas. PMID: 18395252
  100. serum concentrations of CCR4 ligands are up-regulated in atopic dermatitis PMID: 18435706

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Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
Database Links

HGNC: 10615

OMIM: 601520

KEGG: hsa:6361

STRING: 9606.ENSP00000219244

UniGene: Hs.546294

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