HMGB1 Antibody

Datasheet
Code CSB-PA590934XA01CH
Product Type Polyclonal Antibody
Uniprot No. Q9YH06
Delivery Make-to-order
Immunogen Recombinant Gallus gallus (Chicken) HMGB1 protein
Raised in Rabbit
Species Reactivity Gallus gallus (Chicken)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias High mobility group protein B1 (High mobility group protein 1) (HMG-1) HMGB1 HMG1 RCJMB04_15a21
Immunogen Species Gallus gallus (Chicken)
Protocols ELISA Protocol
Gene Names HMGB1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.
Subcellular Location Nucleus, Chromosome, Cytoplasm, Secreted
Protein Families HMGB family
Database Links

KEGG: gga:395724

STRING: 9031.ENSGALP00000027541

UniGene: Gga.4638

Pathway Autophagy
Necroptosis
DNA repair pathway

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