trp Antibody

Code CSB-PA325665XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) trp Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
trp antibody; CG7875 antibody; Transient receptor potential protein antibody
Raised in
Species Reactivity
Drosophila melanogaster (Fruit fly)
Recombinant Drosophila melanogaster (Fruit fly) trp protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.
Gene References into Functions
  1. Calmodulin binding could induce secondary structure changes in Drosophila TRP C-terminus.TRP 783-862 is a novel calmodulin binding site PMID: 29730291
  2. results indicate that properties of the light-activated channels together with the dynamic light-dependent process of TRP phosphorylation at the S936 site determine response kinetics PMID: 28762890
  3. TRP de-phosphorylation affects the detection limit of oscillating light in photoreceptor cells. PMID: 28314815
  4. Data show that phosphorylation of most ransient receptor potential (TRP) ion channel sites depends on the phototransduction cascade and the activity of the TRP. PMID: 24040070
  5. These results indicate that the Pain TRP channels in the MBs and IPCs control neuronal plasticity that is required for the formation of a certain type of long-lasting associative memory in Drosophila. PMID: 23247253
  6. members of the TRP family are "special assignment" channels, which are recruited to diverse signaling pathways. PMID: 11917094
  7. Single amino acid change in the fifth transmembrane segment of the TRP Ca2+ channel causes massive degeneration of photoreceptors. PMID: 12107168
  8. Paper briefly overviews current knowledge of TRP and its mammalian homologues as non-voltage-gated Ca2+ channels that are constitutively active or gated by a multitude of stimuli; thus TRPs may play divergent roles in cell pathophysiology. PMID: 12719655
  9. Data show that a substantial reduction of the TRP channel protein by RNA interference completely rescues neuronal degeneration and significantly improves the light-elicited responses of the eye. PMID: 15342118
  10. TRP has independent channel and scaffolding roles PMID: 16301334

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Note=Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.
Protein Families
Transient receptor (TC 1.A.4) family, STrpC subfamily
Tissue Specificity
Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.
Database Links

KEGG: dme:Dmel_CG7875

STRING: 7227.FBpp0084879

UniGene: Dm.21694

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