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Human Galectin 7(Gal-7) ELISA Kit

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Citations (1) Protocol MSDS
Code CSB-E13454h
Size 96T,5×96T,10×96T
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Product Details

Alternative Names
Gal-7 ELISA Kit; GAL7 ELISA Kit; Galectin 7B ELISA Kit; Galectin-7 ELISA Kit; HKL-14 ELISA Kit; Human keratinocyte lectin 14 ELISA Kit; Keratinocyte lectin 14 ELISA Kit; Lectin galactoside binding soluble 7 ELISA Kit; Lectin; galactoside binding; soluble; 7B ELISA Kit; LEG7_HUMAN ELISA Kit; LGALS7 ELISA Kit; LGALS7A ELISA Kit; LGALS7B ELISA Kit; P53 induced protein 1 ELISA Kit; p53-induced gene 1 protein ELISA Kit; Pi7 ELISA Kit; PIG1 ELISA Kit; TP53I1 ELISA Kit
Abbreviation
Gal-7
Uniprot No.
P47929
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
78 pg/ml-5000 pg/ml
Sensitivity
19.5 pg/ml
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Cancer
Assay Principle
quantitative
Measurement
Sandwich
Precision

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

　

Intra-Assay Precision

Inter-Assay Precision

Sample

1

2

3

1

2

3

n

20

20

20

20

20

20

Mean(pg/ml)

644.292

616.477

630.349

622.774

649.379

631.614

SD

0.030

0.035

0.035

0.041

0.048

0.043

CV(%)

4.249

5.117

5.036

5.951

6.761

6.178

Linearity

To assess the linearity of the assay, samples were spiked with high concentrations of human Gal-7 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

　

Sample

Serum(n=4)

1:1

Average %

91

Range %

88-96

1:2

Average %

95

Range %

90-102

1:4

Average %

97

Range %

94-104

1:8

Average %

101

Range %

95-105

Recovery

The recovery of human Gal-7 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type

Average % Recovery

Range

Serum (n=5)

90

87-96

EDTA plasma (n=4)

98

95-103

Typical Data

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml

OD1

OD2

Average

Corrected

5000

2.819

2.910

2.865

2.739

2500

1.857

1.830

1.844

1.718

1250

1.140

1.057

1.099

0.973

625

0.750

0.729

0.740

0.614

312

0.422

0.422

0.422

0.296

156

0.291

0.311

0.301

0.175

78

0.183

0.177

0.180

0.054

0

0.123

0.129

0.126

　

ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Shelf Life
6 months
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Citations

Related Products

LGALS7 Antibodies

LGALS7 Proteins

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Target Background

Function
(From Uniprot)
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Gene References into Functions
  1. Increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environment. PMID: 28526214
  2. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. PMID: 28594391
  3. Data suggest that evaluation of galectin-7 could help guide postsurgical management for non-metastatic clear cell renal cell carcinoma (ccRCC). PMID: 27259255
  4. these findings reveal the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells. PMID: 29117220
  5. Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis PMID: 27558259
  6. Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD PMID: 27028525
  7. Data indicate that the galectin inhibitor specifically binds galectin-7 (hGal-7), disrupts the formation of homodimers, and inhibits the pro-apoptotic activity of hGal-7 on Jurkat T cells. PMID: 26543238
  8. Galectin-7 regulates keratinocytes proliferation and differentiation through JNK1 pathway. PMID: 26763438
  9. The assessment of a carbohydrate-recognition domain (CRD)-defective mutant form of gal-7 (R7S) showed that the ability of this protein to modulate apoptosis was independent of its CRD activity. PMID: 26168167
  10. our study validates the clinical significance of gal-7 overexpression in ovarian cancer PMID: 25277199
  11. Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. PMID: 25367122
  12. Galectin-7 is produced by the premenstrual and menstrual endometrium, where it accumulates in menstrual fluid and likely acts as a paracrine factor to facilitate post-menstrual endometrial re-epithelialization. PMID: 24782449
  13. Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins. PMID: 25367374
  14. galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with oral squamous cell carcinoma PMID: 24515895
  15. galectin-7 may have a role in amyloidogenesis of primary localized cutaneous amyloidosis PMID: 25172508
  16. C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells PMID: 24789216
  17. Galectin-7 is produced by endometrial epithelium. It is elevated in the endometrium of women with history of miscarriage. We suggest that galectin-7 facilitates adhesion of embryo to endometrium. Elevated galectin-7 may result in abnormal adhesion. PMID: 24522232
  18. galectin-7 may play important roles in downregulating the functions of T lymphocytes after UVB irradiation PMID: 24134186
  19. galectin-7 has a tumor suppressive function, and that the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer. PMID: 23985992
  20. Suggest that the differences in galectin-7 expression and subcellular and extracellular distribution may be crucially involved in the pathogenic process of hypertrophic scars. PMID: 23493985
  21. galectin-7 could be part of a common pathway used by mutant p53 to promote cancer progression PMID: 23967302
  22. The results indicate that lactose binding to human Gal-7 induces long-range effects (minor conformational shifts and changes in structural dynamics) throughout the protein that result in stabilization of the dimer state, with evidence for positive cooperativity. PMID: 23376190
  23. High GAL-7 expression is associated with epithelial ovarian cancer. PMID: 23564797
  24. Knocking down galectin-7 or S100A9 enhanced tumor cell invasion. PMID: 22864818
  25. Because residual cholesteatoma matrix is considered to be one of the main causes of cholesteatoma recurrence, staining with galectin-7 at the time of operation would be a promising way to facilitate complete removal of the residue PMID: 22377647
  26. Extracellular superoxide dismutase plays a role not only as a reactive oxygen species scavenger, but also as a pro-apoptotic factor via COX-2/galectin-7 pathways in the epidermis. PMID: 22251572
  27. high resolution crystal structure of Gal-7 at 1.4 A (a dimer) and its 1.7 A structure in complex with an inhibitor, a sulfur-containing 2-O-benzylphosphate galactoside, a possible antineoplastic agent PMID: 22059385
  28. Data suggest that the binding of Galectin 7 to Bcl-2 may constitute a new target for enhancing the intrinsic apoptosis pathway. PMID: 21289092
  29. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. PMID: 21677144
  30. Data show that high levels of galectin-7 expression in breast cancer cells drastically increased their ability to metastasize to lungs and bones, and were restricted to high-grade breast carcinomas. PMID: 20382700
  31. Proteomics analysis revealed that galectin-7 was highly expressed in esophageal squamous cell carcinoma and could be used as a potential biomarker. PMID: 20546628
  32. Data show that Galectine-7 gene was 8 times up-regulated in bronchial epithelial cells from asthmatic children after RSV infection in vitro and overexpressed in bronchial epithelial cells in asthma in vivo. PMID: 17044979
  33. galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway PMID: 19885589
  34. GAL7 is a negative growth regulator for human neuroblastoma cells. PMID: 13679866
  35. High levels of galectin 7 expression were associated with rapid recurrence rates in hypopharyngeal cancer PMID: 16788763
  36. there was no significant difference in Galectin 7 expression in thyroid tissue in thyroid cancer cases compared to non-cancer cases PMID: 18418527
  37. Gal-7 influence on differentiation in vivo, without evidence for a role in dissemination in head and neck squamous and basal cell carcinomas PMID: 19012243
  38. abnormal expression of galectin-7 in lymphoma cells is not dependent on p53, but is rather associated with DNA hypomethylation. PMID: 19596268

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Subcellular Location
Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity
Mainly expressed in stratified squamous epithelium.
Database Links

HGNC: 6568

OMIM: 600615

KEGG: hsa:3963

STRING: 9606.ENSP00000367891

UniGene: Hs.558355

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