Human Regenerating Islet-derived 1 Alpha/pancreatic Stone Protein/pancreatic Thread Protein (REG1A) ELISA kit

1. Serum levels of PCT and PSP are promising biomarkers for early diagnosis of pediatric acute osteomyelitis. PMID: 29091592
2. PSP/reg levels are significantly up-regulated in diabetic kidney disease patients and might be related to renal injury PMID: 28418911
3. Both univariate and multivariate analysis demonstrated that REG1A expression was associated with OS and PFS, and conducted harmful effects on nasopharyngeal carcinoma progression and survival. This study suggested that REG1A expression could serve as an independent adverse factor for survival in nasopharyngeal carcinoma. PMID: 29162157
4. Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. PMID: 27055226
5. the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated. PMID: 28358790
6. REG1alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Downregulation of REG1alpha expression in urothelial bladder cancer can reduce tumor growth, migration, invasion and angiogenesis. PMID: 28209239
7. REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status. PMID: 27539087
8. We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers PMID: 26240291
9. post-operative serum PSP levels were significantly associated with the presence of infection in both the on-pump and off-pump setting. PMID: 25793700
10. REG Ialpha protein may play a role in angiogenesis during progression of gastric cancer PMID: 25813126
11. PSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. PMID: 25234740
12. the expression of REG Ialpha and REG Ibeta may be upregulated in human beta cells under inflammatory conditions through the JAK/STAT pathway PMID: 25767811
13. Collectively, these findings suggest that REG Ialpha activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity PMID: 25656613
14. Pancreactic stone protein levels were able to diagnose sepsis in patients admitted to intensive care units. PMID: 23531337
15. PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with multiple organ dysfunction syndrome. Patients who died tended to have higher PSP/reg levels. PMID: 24594294
16. REG Ialpha overexpression is a characteristic ofsessile serrated adenoma/polyps of the colon, which appears to reflect aberration of crypt cell compartmentalization. PMID: 24225137
17. The effects of REG IA on AD and SCC cells were different in the in vitro study, and a correlation between REG IA expression and patient prognosis was noted in the in vivo study PMID: 24065141
18. Reduced REG1A expression is associated with chemosensitivity in advanced thoracic esophageal squamous cell carcinoma. PMID: 23645481
19. PSP/reg and CRP are differentially regulated by HNF1A and HNF4A in maturity-onset diabetes of the young PMID: 23803251
20. Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation. PMID: 23519454
21. Reg family proteins stimulate pancreatic beta cell proliferation. PMID: 24055447
22. Autoimmunity to REG Ialpha might play a role in the degeneration of minor salivary gland ductal epithelial cells in primary Sjogren's syndrome. PMID: 23701206
23. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. PMID: 22203215
24. REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis. PMID: 21586335
25. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
26. Regenerating I protein was highly expressed in pure seminoma and in placental-like alkaline phosphatase-positive seminiferous tubules with in situ carcinoma. PMID: 21683984
27. found a significant increase in REG Ialpha in the sera of celiac disease patients when compared with controls PMID: 21867979
28. ELISA showed that the serum level of REG1alpha was significantly higher in patients with pancreatic cancer than it was in the normal controls. PMID: 21691750
29. Raised serum Reg1alpha protein in type 1 and type 2 diabetes and anti-Reg1alpha antibodies in type 1 diabetes, are reported. PMID: 20972946
30. Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. PMID: 20099282
31. REG Ialpha protein may have a pathophysiological role as a biological mediator for immune cell-derived IL-22 in the ulcerative colitis mucosa. PMID: 20065946
32. This finding suggests that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology. PMID: 20056108
33. did not find any association between abnormalities of either reg1 alpha or reg1 beta gene with type 1 diabetes mellitus, fibrocalculous pancreatopathy, or type 2 diabetes mellitus PMID: 11796176
34. Characterization, structural analysis and putative functions. Review. PMID: 12369899
35. REG expression was reported to be an independent predictor of overall gastric adenocarcinoma patient survival PMID: 15022278
36. Reg I alpha protein may play a role in the development of gastric cancers PMID: 15166487
37. Reg I was observed not only in pancreatic acinar cells but also in the duct-like cells and dilated duct cells. Reg I expression was linked to acinar cell dedifferentiation. PMID: 15211106
38. Analysis of the protein in the bile of patients with pancreaticobiliary maljunction/ choledochal cysts PMID: 15628732
39. REG Ialpha gene is inducible by cytokine stimulation and its gene product may function as a mitogenic and/or an antiapoptotic factor in the development of early gastric cancer. PMID: 15765400
40. Damaged heart may be a target for Reg action, and Reg may protect against acute heart stress. PMID: 15778284
41. Polymorphisms in reg1alpha gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. PMID: 17990360
42. REG Ialpha protein mediated the anti-apoptotic effects of STAT3 signaling in gastric cancer cells by enhancing Akt activation, Bad phosphorylation and Bcl-xL expression PMID: 18024479
43. in patients treated with chemoradiotherapy, 8 of 23 REG I-positive patients showed complete responses to chemoradiotherapy; only 1 of 19 REG I-negatives did so; survival rate among REG I-positive patients was significantly better than REG I-negatives PMID: 18259819
44. REG expression in Barrett's esophagus. Expression of REG Ialpha was more frequently observed in patients who showed squamous re-epithelialization of Barrett's esophagus at biopsy sites. PMID: 18289358
45. REG1A is prognostic molecular marker associated with peritoneal carcinomatosis in colorectal cancer and is significantly raised in peritumoral normal tissue compared to mucosa from healthy individuals, suggesting a molecular field effect of secreted REG1A PMID: 18452172
46. The expression of the REG1A gene is closely related to the infiltrating property of primary gastric carcinoma. PMID: 18630596
47. Overexpression of REG1A is associated with breast cancer. PMID: 18781363
48. REG1A enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. PMID: 19032369
49. Expression of REG Ialpha but not REG IV was an independent predictor of poor outcome in patients with gastric cancer. PMID: 19329938
50. The expression of REG gene is closely related to the carcinoma invasiveness of gastric neoplasms. PMID: 14508825

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HGNC: 9951

OMIM: 167770

KEGG: hsa:5967

STRING: 9606.ENSP00000233735

UniGene: Hs.4158