Human Xaa-Pro Dipeptidase/Prolidase(PEPD) ELISA Kit

1. PEPD directly binds to p53 in the nucleus and cytoplasm and suppresses both transcription-dependent and transcription-independent activities of p53, which does not require PEPD enzymatic activity. PMID: 29233996
2. Increased serum prolidase activity and decreased antioxidant levels are likely to be a results of increased of oxidative stress levels in obese subjects PMID: 28867357
3. Serum prolidase activity is reduced in scleroderma patients, especially in diffuse form. PMID: 28534076
4. Increased levels of serum prolidase activity are associated with the severity of developmental dysplasia of the hip. PMID: 27320745
5. High resolution X-ray crystallographic models of substrate and product binding in the active site of human prolidase. PMID: 28677335
6. We report here that by introducing either the A252R or P365R substitution mutation, the structural changes affecting catalytic turnover rate and substrate binding affinity are valuable in improving the catalytic activity of human prolidase towards toxic organophosphorus compound hydrolysis. PMID: 28462712
7. In ankylosing spondylitis, serum prolidase level was successful in measuring disease activity PMID: 27443556
8. there is an independent relationship of aortic prolidase activity and aortic prolidase immunostaining with aortic stiffness beta index in patients who underwent coronary artery bypass grafting PMID: 27387023
9. Prolidase activity decreases in patients with chronic obstructive pulmonary disease. PMID: 26870880
10. absence of prolidase activity in pterygium tissue indicates that there is no collagen turnover in this tissue PMID: 26509313
11. Decreased serum prolidase activity may be associated with knee osteoarthritis PMID: 25994092
12. The association between the PEPD genetic variant and the risk of T2D was modulated by n-3 fatty acids. Higher n-3 fatty acids may abolish the adverse effect of the risk allele at PEPD for T2D PMID: 26087900
13. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control. PMID: 26159719
14. Levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. PMID: 26078578
15. Serum prolidase level was significantly higher in schizophrenia patients compared to the controls. PMID: 25842545
16. There may be an ethnic- and/or sex-specific association of the PEPD rs731839 single nucleotide polymorphism and serum lipid levels in Mulao and Han populations PMID: 25120796
17. Prolidase is required for early trafficking events during influenza A virus entry. PMID: 25031340
18. High prolidase activity may indicate critical biological activities relevant to pathological events in Behcet's disease, and this activity may be a biological indicator of disease. PMID: 24225260
19. Significantly lower prolidase activity in patients with benign joint hypermobility syndrome suggests that prolidase may affect the collagen metabolism and cause hyperlaxity. PMID: 24612543
20. Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis. PMID: 24484408
21. Suggest prolidase as a high affinity ligand of the ErbB2 receptor which can regulate ErbB2 signaling and cell growth. PMID: 24810047
22. Patients with psoriasis exhibit higher serum prolidase activity independent of gender, BMI, disease severity or duration, type of treatments or nitric oxide level. PMID: 23553128
23. Data suggest that elevated serum prolidase activity and oxidative stress may be associated with increased cardiovascular risk in polycystic ovary syndrome (PCOS) and/or menstrual irregularities associated with this syndrome. PMID: 23163753
24. Prolidase dependent HIF1A expression in breast cancer cells is induced by prolidase substrate peptides. PMID: 23549681
25. prolidase may share an undefined role in fibrosis in heart failure and may have a role in the diffuse fibrosis of heart failure. PMID: 24065222
26. Serum PEPD activity appears to be higher in patients with diabetic foot ulcers when compared with patients without diabetic foot ulcers and healthy controls. PMID: 23242638
27. kinetic and structural evidences on human prolidase pathological mutants PMID: 23516557
28. Varicose venous wall prolidase enzyme activity could be an important factor in progression of azoospermia and infertility in patients with varicocele. PMID: 23171426
29. PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation PMID: 23212918
30. A diminished prolidase activity may contribute to alteration of collagen metabolism and should be considered a biomarker of myeloproliferative neoplasms progress. PMID: 23457135
31. Although approximately 70 PEPD gene mutations and polymorphisms have been reported in various ethnic groups, we however report, for the first time, the identification of insertion mutation in human the PEPD gene. PMID: 23287645
32. A Mn(II)-Mn(II) center in human prolidase. PMID: 22999980
33. Assessed the serum prolidase enzyme level and the oxidative-antioxidative status in chronic hepatitis C infection. The prolidase was higher in the chronic hepatitis C group compared to the control group. PMID: 22811354
34. Increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer. PMID: 22258852
35. Relinoic acid regulates prolidase activity in human dermal cells via IGF receptor signaling in photoaged cells. PMID: 22245250
36. elevated in submucosal uterine fibroids PMID: 22185542
37. Serum prolidase activity is elevated in patients with pulmonary tuberculosis PMID: 21722016
38. Prolidase activity was positively correlated erum prolidase activity is significantly associated with Legg-Calve-Perthes disease. PMID: 21304409
39. In the early pregnancy loss group compared to the control group, serum levels of prolidase activity were significantly lower and placental tissue activity levels were significantly higher. PMID: 20437180
40. investigation of role of prolidase in regulation of expression of TGF beta1 & TGF beta1 receptor in skin fibroblasts: down-regulation by prolidase inhibitors (Cbz-Pro & PEP); up-regulation by prolidase products (Pro & HyPro) PMID: 20868675
41. Serum prolidase activity seems to be correlated with the level of fibrosis in patients with non-alcoholic steatohepatitis. PMID: 20486204
42. found serum prolidase activity was significantly lower in both Idiopathic and ischemic dilated cardiomyopathies (DCM) groups relative to healthy volunteers and lower in ischemic DCM than idiopathic. PMID: 20626024
43. Data suggest that the presence of ascending aortic aneurysms is associated with low serum prolidase activity. PMID: 20383038
44. Data shows prolidase activity was significantly increased in patients with thalassemia major compared with controls. PMID: 20087956
45. FAK-independent regulation of prolidase activity and collagen biosynthesis in MCF-7 cells. PMID: 11820613
46. Carbobenzoxyproline is a potent inhibitor of prolidase in cultured fibroblasts from patients with prolidase deficiency. PMID: 15878628
47. Significant correlation was observed between serum prolidase activity, and total antioxidant capacity, total oxidant status and oxidative stress index (p<0.01, r=-0.367; p<0.05, r=0.283; p<0.01, r=0.379; respectively) in H. pylori-positive subjects. PMID: 16999949
48. oxidative stress and decreased prolidase activity may have a role in pathogenesis of knee osteoarthritis PMID: 17096092
49. Prolidase is viable target for selective activation of melphalan prodrugs in melanoma cells. PMID: 17377743
50. Prolidase deficiency and systemic lupus erythematosus share a number of common immunological features. PMID: 17570078

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HGNC: 8840

OMIM: 170100

KEGG: hsa:5184

STRING: 9606.ENSP00000244137

UniGene: Hs.36473