Human neutrophil gelatinase-associated lipocalin,NGAL ELISA Kit

Code CSB-E09408h
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Product Type ELISA Kit
Uniprot No. P80188
Lead Time 3-5 working days
Abbreviation NGAL
Protein Biological Process 1 Metabolism
Target Name lipocalin 2
Alias 24p3, MSFI, NGAL, OTTHUMP00000022240|migration-stimulating factor inhibitor|neutrophil gelatinase-associated lipocalin|oncogene 24p3|siderocalin
Species Homo sapiens (Human)
Protein Biological Process 3 Apoptosis
Sample Types serum, plasma, urine, tissue homogenates
Detection Range 15.6 pg/mL-1000 pg/mL
Sensitivity 3.9 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Metabolism
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Standard Curve
References
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Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation
Subcellular Location Secreted
Protein Families Calycin superfamily, Lipocalin family
Tissue Specificity Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or pe
Database Links

HGNC: 6526

OMIM: 600181

KEGG: hsa:3934

STRING: 9606.ENSP00000277480

UniGene: Hs.204238

Pathway IL-17 signaling pathway

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