Recombinant Human Neutrophil gelatinase-associated lipocalin protein(LCN2) (Active)

In Stock
Code CSB-AP000461HU
Product Type Other
Size $112Purchase it in Cusabio online store
(Shop online in the US. Customers outside the US,
please order from local distributors.)
Uniprot No. P80188
Image
Storage Buffer 0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
Alias NGAL, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG
Research Area Cancer
Source E.Coli
Gene Names LCN2
Expression Region 21-198aa
Tag Info Tag-Free
Mol. Weight 41.0 kDa
Protein Description Full Length of Mature Protein
PubMed ID 8060329; 9339356; 14702039; 15164053; 15489334; 7835423; 7683678; 1281792; 12453413; 15084671; 16335952; 16740002; 19229297; 19159218; 21269460; 10684642; 10339412; 12453412
Still Have Questions? Leave a Message or Start an on-line Chat
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation
Subcellular Location Secreted
Protein Families Calycin superfamily, Lipocalin family
Tissue Specificity Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or pe
Database Links

HGNC: 6526

OMIM: 600181

KEGG: hsa:3934

STRING: 9606.ENSP00000277480

UniGene: Hs.204238

Pathway IL-17 signaling pathway

Related Products

LCN2 Antibodies

LCN2 Antibodies for Homo sapiens (Human)

LCN2 Antibodies for Human

LCN2 Proteins

LCN2 Proteins for Homo sapiens (Human)

LCN2 ELISA Kit

LCN2 ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.