Mouse Fetuin A ELISA Kit

Instructions
Code CSB-E14042m
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name alpha-2-HS-glycoprotein
Alternative Names Ahsg ELISA kit; FetuaAlpha-2-HS-glycoprotein ELISA kit; Countertrypin ELISA kit; Fetuin-A ELISA kit
Abbreviation AHSG
Uniprot No. P29699
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 6.25 ng/mL-400 ng/mL
Sensitivity 1.56 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Metabolism
Precision
Linearity
Recovery
Typical Data
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Data

Function Probably involved in differentiation.
Gene References into Functions
  1. Downregulation of adiponectin in inflamed adipocyte by fetuin-A through the mediation of Wnt3a and PPARgamma is a new report. PMID: 27720679
  2. FETUA expression and ER stress markers in the liver and serum of HFD mice were decreased by melatonin treatment. In conclusion, melatonin can improve hepatic insulin resistance and hepatic steatosis through reduction in ER stress and the resultant AHSG expression. PMID: 29607540
  3. Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A. PMID: 29030114
  4. The growth plate slippage occurred in 70% of Ahsg-/- mice of both sexes around three weeks postnatal. PMID: 29088242
  5. AHSG is produced in bone, mainly in osteocytes and also show for the first time that its production is modulated by FGF23. PMID: 26476373
  6. These findings establish urinary Fetuin-A as a sensitive biomarker of the progression of autosomal dominant polycystic kidney disease. PMID: 25888842
  7. Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls. PMID: 24994603
  8. fetuin-A regulates endochondral ossification through mineralization inhibition and lipid (hormone) binding [review] PMID: 23277412
  9. Our results show that CSF fetuin-A is a biomarker of disease activity and natalizumab response in multiple sclerosis PMID: 23439582
  10. lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization PMID: 23943623
  11. FetA, via its terminal galactoside moiety, directly binds Leu100-Gly123 & Thr493-Thr516 in Tlr4, fulfilling the requirement of an endogenous ligand for TLR4 through which lipids induce insulin resistance. PMID: 22842477
  12. Our results show that fetuin-A has a developmental rather than a structural role in murine bone. PMID: 23091616
  13. Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A. PMID: 22753077
  14. ER stress induced by high glucose and palmitate increases the expression of fetuin-A and further contributes to the development of insulin resistance PMID: 22619360
  15. fetuin-A is protective against lethal systemic inflammation partly by inhibiting active HMGB1 release PMID: 21347455
  16. Fetuin-A deficiency is associated with soft tissue calcification in mice and humans. PMID: 21659653
  17. breast cancer but also of other tumors whose initiation and promotion are under the tight control of TGF-beta. PMID: 20847285
  18. Fetuin-A expressions were negatively correlated with the liver pathological scores and TNFa levels in fulminant hepatic failure. PMID: 18578995
  19. alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling PMID: 11901155
  20. Improved insulin sensitivity and resistance to weight gain in knockout mice PMID: 12145157
  21. role as a systemically acting inhibitor of ectopic calcification PMID: 12897203
  22. Regulation of BMP-induced ectopic bone formation by Ahsg. PMID: 15885488
  23. Onset of malaria infection is delayed in fetuin-A-deficient mice compared to that in wild-type C57BL/6 mice challenged with Plasmodium berghei sporozoites PMID: 16113307
  24. Fetuin-A knockout (fetuin-KO) mice spontaneously develop widespread soft tissue calcification, including significant myocardial calcification, whereas larger arteries are spared. PMID: 16177000
  25. The absence of fetuin may contribute to the improvement of insulin sensitivity associated with aging. PMID: 17011519
  26. Fetuin-A deficiency, chronic kidney disease, and high phosphate diet act synergistically in the pathogenesis of extraosseous calcification. PMID: 17389622
  27. fetuin recognized by anti-LY-R antibodies is an immunogenic form associated only with the tumorigenic LY-R cells and might be involved in tumor progression in this lymphoma. PMID: 19194829
  28. inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis PMID: 19389852
  29. inhibition of ectopic calcification PMID: 12556469
  30. inhibition of ectopic calcification PMID: 9395485

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Subcellular Location Secreted
Protein Families Fetuin family
Tissue Specificity Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.
Database Links

KEGG: mmu:11625

STRING: 10090.ENSMUSP00000023583

UniGene: Mm.197554

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