Gene References into Functions |
- AQP2 is crucial for the activation of SK3 by TRPV4, leading to hyperpolarization of the plasma membrane. PMID: 29243846
- AQP2 expression is markedly increased in kidneys following chronic stress. PMID: 30021346
- Low AQP2 expression is associated with hypertension. PMID: 30009821
- ezrin facilitates AQP2 endocytosis, thus linking the dynamic actin cytoskeleton network with AQP2 trafficking. PMID: 28754689
- Results provide evidence that NHE2 and AQP2 work in coordination as part of the cellular device that regulates collecting duct cell cycle progression. PMID: 27191152
- The results of this study using multiple approaches and 2 different animal models of hypercalcemia revealed that autophagic degradation of a specific set of proteins including AQP2 was observed at the early onset of nephrogenic diabetes insipidus. PMID: 28139295
- PP2C activity is required for S261 AQP2 dephosphorylation upon vasopressin stimulation, which occurs independently of S256 phosphorylation. PMID: 28381458
- aquaporin-2 regulates serine/threonine phosphatases in renal collecting duct PMID: 27784696
- These results suggest that Ser-261 phospho-regulation is involved in pS256- and pS269-mediated AQP2 apical translocation. PMID: 28668390
- These results provide the direct evidence that the Ser-261 dephosphorylation is involved in the pS256- and pS269-related AQP2 regulation. PMID: 27889609
- Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea. PMID: 27022218
- Data show that enhanced autophagic degradation of proteins, most notably including aquaporin-2 (AQP2), is an early event in hypokalemia-induced nephrogenic diabetes insipidus (NDI). PMID: 26674602
- Remote ischemic perconditioning prevents dysregulation of renal water and salt handling via regulation of AQP2 expression and phosphorylation as well as via regulation of Na-K-ATPase expression in I/R rat kidneys. PMID: 27405971
- the activation of CaSR in the collecting duct prevents the cyclic AMP-dependent increase in AQP2-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin response. PMID: 25977473
- Therefore, we suggest that there is a regional heterogeneity of regulation of renal NPRs, TonEBP, and APQ-2 mRNA in acute kidney injury . PMID: 25858778
- increased expression in facial nerve following crush injury PMID: 25762220
- AVP-induced increase in AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidney. PMID: 25658446
- Suggest ERalpha in mediates the inhibitory effect of estradiol on AQP2 expression in collecting ducts. PMID: 26062878
- Exercise training decreased AQP-2 and beta-tubulin protein expression. PMID: 21251048
- The direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. PMID: 25694485
- Reduced activity of PP2A, secondary to reduced intracellular Ca2+ levels, promotes AQP2 trafficking independently of the arginine vasopressin-protein kinase A axis. PMID: 24700872
- Developed a systematic procedure for identifying new compounds that modulate AQP2 trafficking using high throughput screening, in vitro assays in cells/kidney slices, and in vivo testing in an animal model. PMID: 24944200
- The data demonstrate that VACM-1 is involved in the regulation of AQP2 protein concentration and may play a role in regulating water balance. PMID: 23171819
- It is a water channel and its abnormal gene expression in kidney causes a disorder of urine concentrating ability. PMID: 24531898
- These data suggest that an increased plasma level of vasopressin promoted the excretion of urinary exosomal AQP2 and that urine alkalinization also increased it independently of vasopressin. PMID: 23986519
- Hypothyroidism contributes in a differential way to aging-induced changes in renal function, and medullary NO and AQP2 would be implicated in maintaining water homeostasis. PMID: 23706747
- An increase in cell proliferation is observed in renal cells expressing AQP2. PMID: 22786728
- Antidiuretic hormone might play an important role in controlling the expression of AQP-2 in the endolymphatic sac and kidney. PMID: 15338864
- Emodin can inhibit the genetic transcription and translation of AQP2 gene in NRK cells. PMID: 21038660
- Protein expression of AQP2 was significantly lower after ovariectomy and was restored to the control levels after 17beta-estradiol treatment. This suggests that AQPs may have a role in detrusor overactivity that occurs with hormonal alteration in female rat. PMID: 21479884
- Our data provide evidence of a novel association between TRPV4 and AQP2 that is involved in the activation of TRPV4 by hypotonicity and regulation of cellular response to the osmotic stress PMID: 21938744
- Report age-related changes in expression of renal AQP2 in response to congenital, partial, unilateral ureteral obstruction in rats. PMID: 22028046
- Report AQP2 up-regulation in the solitary kidney in response to partial ureteral obstruction in neonatal rats. PMID: 21677414
- Data suggest that EP2 and EP4 agonists increase AQP2 phosphorylation and trafficking, likely through different signaling pathways. PMID: 21768374
- Simvastatin -induced membrane accumulation of AQP2 in cultured cells and kidney slices in vitro is mainly due to reduced endocytosis rather than increased exocytosis. PMID: 21511701
- downregulation of AQP2 could in part be caused by degradation of AQP2 through a lysosomal degradation pathway PMID: 21525134
- AQP2 was mainly localized to the type II, IV, and V fibrocyte of the spiral ligament of the inner ear. Interaction between AQP1, AQP2 and AF might be possible. PMID: 17628981
- KCC1 affects water transport solely by K(+) extrusion. Intracellular K(+) retention conceivably leads to cell swelling, followed by an increased rate of endocytic AQP2 retrieval from the apical membrane. PMID: 21112289
- Elevation of cAMP increased AQP2 protein levels within 30 minutes in primary inner medullary collecting duct cells. PMID: 20724536
- AQP2 expression facilitates cell swelling or shrinkage leading to the activation of channels necessary to the control of cell proliferatio and apoptosis. PMID: 20432437
- Upregulation of AQP2 expression is maintained dependent upon non-suppressible release of arginine vasopressin in rats with glucocorticoid deficiency. AQP2 plays a crucial role in impairment of water excretion in aged rats with glucocorticoid deficiency. PMID: 19040709
- These results demonstrate that NSAIDs decrease AQP2 protein abundance, particularly during adaptation during dehydration. PMID: 20130117
- The results indicate that COX-2 inhibition does not mimic ANG II receptor (AT1R) blockade-mediated effects and that AT1R-mediated AQP2 regulation in the postobstructed kidney collecting duct is independent of COX-2 induction. PMID: 20107111
- These studies suggest that Ser269 phosphorylation may be a more consistent indicator of vasopressin action and AQP2 membrane abundance than is Ser256 phosphorylation. PMID: 20089674
- delineates induction and degradation mechanisms of AQP2 endogenously expressed by a renal collecting duct principal cell line PMID: 11782489
- Aquaporin-2 transcription is differentially regulated by dietary salt in Sprague-Dawley and Dahl SS/Jr rats PMID: 12176047
- by elevated effective osmolality (tonicity) is crucial for the expression of AQP2 in inner medullary cells of the kidney PMID: 12388395
- AQP2-bearing vesicles are a unique intracellular compartment distinct from the endoplasmic reticulum, Golgi apparatus, trans-Golgi network and lysosome. Endosomes might be involved in the trafficking of AQP2. PMID: 12422412
- cAMP initiates an early step, namely the transport of AQP2-bearing vesicles towards the plasma membrane. The data do not support a regulatory function for Ca(2+) in the AQP2 shuttle. PMID: 12524527
- The expression of the collecting duct water channel AQP2, p-AQP2 and AQP3 was significantly downregulated after hemorrhagic shock (HS), which may play an important role in the impaired urinary concentrating ability in HS-induced acute renal failure. PMID: 14605277
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