Recombinant Human Interleukin-17F protein(IL17F) (Active)

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Code CSB-AP001841HU
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of >5.0x104 IU/mg.
Target Names IL17F
Uniprot No. Q96PD4
Research Area Immunology
Alternative Names CANDF6; Cytokine ML 1; Cytokine ML-1; IL 17F; IL 24; IL-17F; IL-24; Il17f; IL17F_HUMAN; Interleukin 17F; Interleukin 24; Interleukin-17F; Interleukin-24; ML 1; ML1; Mutant IL 17F; OTTHUMP00000016602
Species Homo sapiens (Human)
Source E.Coli
Expression Region 31-163aa
Mol. Weight 15 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Ligand for IL17RA and IL17RC
Gene References into Functions
  1. the results suggest that IL17F genetic polymorphism is not associated with the development of rheumatic heart disease in South Indian population PMID: 29985710
  2. The expression of IL-6 gene and protein was significantly induced by IL-17F. IL-17F activated TAK1 and NF-kappaB in airway smooth muscle cells. PMID: 28474507
  3. IL-17FA7488G polymorphism was not significantly associated with colorectal cancer risk PMID: 29970680
  4. a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk and this association could be modified according to the IL-17F rs763780 genotype and anatomic site. PMID: 29874787
  5. Malignant T cells activate endothelial cells via IL-17 F. PMID: 28731459
  6. The AA genotype on 7489A/G single nucleotide polymorphism of IL-17F and the A allele might be associated with a lower risk of acute rejection with better graft survival in kidney transplant recipients. PMID: 29407292
  7. Findings suggest that IL-17F rs1889570 gene polymorphisms are significantly associated with the susceptibility to severe EV71 infection in Chinese Han children. PMID: 29549443
  8. P-TEFb is involved in IL-17F-induced IL-8 expression and that steroids diminish it via the inhibition of CDK9 phosphorylation. PMID: 29649811
  9. The IL-17F (+7488A/G) genotype revealed a significantly increased risk of accelerated silicosis. The IL-17F (+7488 G) allele was associated with an increased risk of accelerated silicosis. PMID: 28481151
  10. developed ultrasensitive methods for measuring IL-17A and IL-17F in human serum samples and found that serum from psoriasis patients had higher and a broader range of concentrations of both IL-17 proteins compared to healthy volunteers PMID: 28534291
  11. SNPs of rs3819024 in IL-17A and rs763780 in IL-17F were weakly related to a prognosis of tuberculosis. PMID: 27339100
  12. IL17F (rs2397084) and IL10 (rs1800871) genes are associated with functional dyspepsia. PMID: 28965252
  13. a mutation in IL-17F is associated with susceptibility to recurrent aphthous stomatitis PMID: 29458167
  14. the G allele at rs763780 (IL-17F) was significantly associated with Takayasu Arteritis in Asian Indian population PMID: 28438554
  15. levels of mRNA IL-17F and IL17F might be useful parameters for the diagnosis of atopic asthma patient PMID: 28606156
  16. IL-17F rs763780 polymorphisms may be associated with the development of primary immune thrombocytopenia in a Chinese Han population. PMID: 26620416
  17. In this study, IL-17F was demonstrated to have functions comparable to IL-17A in human keratinocytes. PMID: 27576147
  18. Serum IL-17F predicted increased knee bone marrow lesion scores in females only among patients with knee osteoarthritis. PMID: 27836676
  19. IL-17A and IL-17F polymorphisms therefore have the potential to act as predictive biomarkers for cervical cancer risk PMID: 28621613
  20. The results suggest the possible involvement of the polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy. PMID: 28470012
  21. our study provides an inclusive meta-analysis of the function of IL-17A rs2275913 and IL-17F rs763780 genetic variations in inflammatory diseases risk. The results indicated that these two genetic variations of IL-17A and IL-17F were risk factors for inflammatory diseases, particularly RA. PMID: 28186427
  22. This meta-analysis with seven articles in 697 patients diagnosed with chronic periodontitis , 188 patients diagnosed with aggressive periodontitis and 655 control patients totaling 1540 participants showed a non-significant association between the rs2275913 polymorphism in the IL-17A gene and the rs763780 polymorphism in the IL-17F gene with the risk of chronic periodontitis, or with aggressive periodontitis PMID: 29027636
  23. our study provides the evidence that functional IL-23R rs1884444 G/T and IL-17F rs763780 A/G polymorphisms may be a new genetic susceptibility factor to SLE, especially in the Polish population. PMID: 27320770
  24. IL23R rs10889677 and IL17A rs2275913 were not associated with the susceptibility to Necrotizing enterocolitis (NEC). In conclusion, data suggest that a variant of IL17F (rs763780) may contribute to the development of NEC. PMID: 28224332
  25. Our results confirmed IL17A and IL17F as potential candidate genes involved in RA. They play pivoting roles in the susceptibility and in clinical features of RA disease. Responses to RA treatments are differently conditioned by polymorphisms in IL17A and IL17F genes. PMID: 28143790
  26. IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of rheumatoid arthritis in a Polish population. PMID: 27169372
  27. we aimed to investigate the associations between the 7383A/G and 7488A/G polymorphisms of the interleukin (IL)-17F gene with disease activity and clinical outcomes in Turkish patients with ankylosing spondylitis PMID: 27155445
  28. Using an in-vitro migration assay, B cells were shown to migrate towards both IL-17A and IL-17F. These observations indicate a direct chemotactic effect of IL-17 cytokines on primary peripheral blood B cells with higher effect being on asthmatic B cells. PMID: 25494178
  29. IL-17-related cytokines expression was amplified in bronchial/nasal mucosa of neutrophilic asthma prone to exacerbation, suggesting a pathogenic role of IL-17F in frequent exacerbators. PMID: 27931975
  30. IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to rheumatoid arthritis or secondary Sjogrens syndrome (sSS, p > 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS. PMID: 26232893
  31. It can be stated that the IL17A and IL17F polymorphisms are not markers of susceptibility to psoriasis. However, the IL17F polymorphism may affect the response to NB-UVB therapy. PMID: 27591988
  32. Elevated aAbs against IL-17F correlate with disease activity in patients with early rheumatoid arthritis. PMID: 26087054
  33. Study provides evidence that polymorphisms of both IL-17A and IL-17F may increase lung cancer risk in Chinese population. PMID: 26073462
  34. this study shows that Korean patients with psoriasis show a strong association for IL17F single nucleotide polymorphism PMID: 27774581
  35. we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer. Allele and genotype frequencies of IL-17A rs2275913 were significantly different between patients and controls with rs2275913 (197 G/A) AA and GA+AA genotypes compared to the GG genotype significantly higher in patients. PMID: 28362993
  36. These findings identify a novel biological function for IL-17A/F as an indirect angiogenic agent. PMID: 27594509
  37. IL-17F was correlated with increased autoantibody levels and disease activity in primary Sjogren's syndrome and is more clinically relevant than IL-17A. PMID: 28210632
  38. No relationship between IL17F rs763780 and rs9463772 polymorphisms and Henoch-Schonlein purpura susceptibility. PMID: 27021337
  39. Single nucleotide polymorphisms in IL-17F A7488G but not IL-17A are associated with the development of chronic immune thrombocytopenia in China. PMID: 27312555
  40. Study represents a comprehensive meta-analysis of the role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in cancer risk and demonstrated that these two polymorphisms significantly increase the risk of development of cancer, particularly gastric cancer. PMID: 26843459
  41. Levels of IL-17FF were significantly higher in rheumatoid arthritis sera and showed a trend of increase in relapsing remitting multiple sclerosis, as compared with normal healthy subjects. PMID: 27620302
  42. Polymorphism of IL-17 rs3748067 and rs763780 is closely associated with gastric cancer development. Polymorphism of L-17 rs2275913 and rs4711998 may be correlated with the risk for gastric cancer. PMID: 27097946
  43. ELISA analysis verified high levels of Th17-associated proinflammatory cytokines such as interleukin-17A/F, interleukin-6 and interleukin-23 and low levels of inflammatory inhibitory factors including interleukin-10 and transforming growth factor-beta in primary immune thrombocytopenia patients compared with normal controls. PMID: 26484642
  44. The GGAGAA combined genotype and the GGA haplotype of IL-17A rs2275913, IL-17F rs763780 and rs2397084 can be considered risk factors for the development of systemic lupus erythematosus in Egyptian children. PMID: 26515887
  45. GA genotype of the rs11465553 IL17F gene polymorphism may be associated with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation. PMID: 26447633
  46. No associations were found between rs8193036, rs2275913 and rs3748067 in IL-17A and rs763780 in IL-17F SNPs and myasthenia gravis in Chinese patients PMID: 26337284
  47. No evidence of the association was observed between rs3748067, rs3819025, rs763780, rs9382084, and rs1266828 polymorphisms and the risk of cervical cancer. PMID: 26505366
  48. higher expression level in chronic lymphocytic leukemia patients PMID: 26478573
  49. In vitro, CSE stimulation significantly increased IL-17F and IL-17R in 16HBE (2.5%) and A549 (5%) while IL-17A and IL-17F in PBMC (10%). IL-17A and CSE stimulation, rather than CSE or rhIL-17A alone, increased proliferation in 16HBE and apoptosis in A549 PMID: 26198032
  50. A G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2. PMID: 26558270
  51. Genotyping of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 genes was performed by multiplex PCR assays PMID: 26464720
  52. The results of the univariate analysis showed an association between rs10484879 and psoriasis, although this relationship disappeared after adjustment for HLA-C PMID: 26415694
  53. data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of preeclampsia in Chinese Han women. PMID: 26451724
  54. Review/Meta-analysis: The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer. PMID: 26445528
  55. Correlation analysis of SNPs to different clinical variables showed a significant correlation between IL-17F rs1889570 SNP and the number of allergens sensitized PMID: 26108303
  56. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed PMID: 26345782
  57. the IL-17A rs2275913 polymorphism may affect the development of coronary artery disease (CAD); however, no significant association was observed between the IL-17F rs763780 polymorphism and risk of CAD. PMID: 26436389
  58. IL17F and IL17RA polymorphisms modulate susceptibility to cerebral malaria (CM) and provide evidence that IL-17F protects against CM. PMID: 26667835
  59. To investigate the impacts of these polymorphisms (IL-17A G197A, the IL-17F 7488A/G, and the IL-17F 7383A/G) on the severity and susceptibility of RA in a Turkish population. PMID: 26154773
  60. IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil PMID: 26339129
  61. The effect of IL-17 cytokine in pre-eclampsia is not due to the studied cytokine polymorphisms but local production of IL-17 might have an effect on the predisposition to the disease. PMID: 26119194
  62. IL-17F G single mutant and GG mutation homozygote were correlated with acute myeloid leukemia susceptibility PMID: 26191290
  63. The polymorphism IL-17F rs1889570(C/T)may be a potential risk factor for asthma susceptibility. PMID: 26300019
  64. suggest that IL-17F rs763780 play a critical role in the etiology of pulmonary tuberculosis PMID: 26045845
  65. The IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms are risk factors for gastric cancer development. (Meta-analysis) PMID: 26125910
  66. IL17F may serve as an independent prognostic factor for overall survival in patients with colorectal cancer. PMID: 26083022
  67. This study indicates that IL-17F may be involved in pathogenesis of periodontitis like IL-17A. PMID: 25384562
  68. Interleukin-17F gene polymorphism and its elevated serum levels are associated with recurrent pregnancy loss. PMID: 26467330
  69. Results show that IL-17F (7488T/C) polymorphism may not associate with gastrointestinal diseases. However, AA genotype of IL-17A (-197G/A) may be an important predisposing factor in gastrointestinal diseases, especially in gastrointestinal cancer. PMID: 26164762
  70. Expression of both IL-17A and IL-17 F is increased by the cigarette smoke exposure in explants from both non-COPD and COPD subjects, supporting that local lung cells contribute IL-17 production. PMID: 25427574
  71. Increased expression of TLR2 contributes to immune reactivity and promotes IL-17A and IL-17F expression through histone modifications in systemic lupus erythematosus. PMID: 26079624
  72. IL-17F plasma levels were increased in rheumatoid arthritis patients and responsive to anti-rheumatic agents. PMID: 25240765
  73. Polymorphisms in the IL17F gene are associated with recurrent pregnancy loss in Iranian women. PMID: 25227691
  74. nasal IL-17F inflammation might be informative of bronchial IL-17 inflammatory pattern associated with bronchial neutrophilia in SA prone to asthma exacerbations. PMID: 25394579
  75. single nucleotide polymorphisms in the proinflammatory IL17A and IL17F genes (rs2275913 and rs763780, respectively), were not significantly associated with tuberculosis in the Croatian population. PMID: 25857634
  76. IL-23 has a role in regulating IL-17A and/or IL-17F positive Th17 cells in chronic periodontitis PMID: 25525302
  77. IL-17A rs2275913 A/G polymorphism and IL-17F rs763780 C/T polymorphism might be associated with increased gastric cancer risk in Asians. PMID: 25500254
  78. IL-15 and IL-17F are differentially regulated and expressed in MF. We propose that IL-15 and IL-17F are markers for different inflammatory environments and play distinct roles in the development and progression of MF. PMID: 24621498
  79. But we did not observe a significant association between polymorphisms in rs3748067, rs3819025, rs763780, rs9382084, and rs1266828 polymorphisms ( IL-17A and IL-17F )and risk of cervical cancer. PMID: 25596084
  80. the serum level of IL-17F and the ratio of IL-17F/VEGF were positively associated with the numbers of CD3(+) CD4(+) T cells, which indicated that serum IL-17F could originate from PBMCs during the development of oral squamous cell carcinoma PMID: 25613064
  81. IL-17F 7488A/G is associated with susceptibility to silicosis. PMID: 25374205
  82. IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both acute generalized exanthematous pustulosis and generalized pustular psoriasis. PMID: 25030504
  83. IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer. PMID: 25338988
  84. the T allele of IL-17F T7488C polymorphism may be involved in reduced risk of colorectal cancer PMID: 25680555
  85. High gene copy numbers of IL17F and IL23A were associated with Behcet's disease and Vogt-Koyanagi-Harada syndrome. PMID: 25439430
  86. A significantly increased frequency of rs763780 genotype and T allele in IL-17f was detected in Multiple Sclerosis patients compared with controls. PMID: 24857622
  87. IL-17A and IL-17F polymorphisms can interact with smoking and drinking to enhance the risk of OSCC developing PMID: 25579009
  88. results suggest that patients carrying a combination of SNPs for TNF-alpha, VEGF-A, and IL-17F of ACGTCT haplotype may have an increased risk of corneal allograft rejection compared with patients carrying other haplotypes PMID: 24935327
  89. IL-17F gene SNP 7489A/G is associated with renal graft failure PMID: 24507036
  90. Studies suggest that interleukin-17F (IL-17F) polymorphism may modify the risk of cancer, particularly gastric cancer. PMID: 24913709
  91. The IL-17F (7488T>C) single-nucleotide polymorphism is associated with susceptibility to leprosy. PMID: 24164796
  92. genetic polymorphism is associated with clinical features of colorectal cancer in Tunisia PMID: 24440568
  93. The rs763780 IL-17F polymorphism appeared to be associated with susceptibility to the disease. PMID: 24793548
  94. The association of three single-nucleotide polymorphisms (SNPs: -152 G/A, 7488 A/G and 7383 A/G) in the IL-17A and IL-17F genes with lung cancer risk, was investigated. PMID: 24548421
  95. IL17F rs763780 polymorphism is inversely associated with development of subacute sclerosing panencephalitis. PMID: 24690400
  96. IL-17F T7488C polymorphism did not increase or decrease cancer risk under all genetic models PMID: 24965422
  97. The contribution of the studied IL-17 F T7488C, TNF-alpha G-308A gene polymorphisms is highly related to the disease phenotype manifestations and peculiar issues associated with therapy volume. PMID: 24933943
  98. IL-17F gene variants associated with childhood asthma susceptibility in Tunisia. PMID: 24393079
  99. Recombinant IL-17A and IL-17F significantly inhibit Fas-induced cell death in Fas-sensitive T cells from healthy donors. PMID: 24363402
  100. the IL17A and IL17F loci have divergent epigenetic architectures in unstimulated HuT-102 and primary Th17 cells. PMID: 23800789

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Involvement in disease Candidiasis, familial, 6 (CANDF6)
Subcellular Location Secreted
Protein Families IL-17 family
Tissue Specificity Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Database Links

HGNC: 16404

OMIM: 606496

KEGG: hsa:112744

STRING: 9606.ENSP00000337432

UniGene: Hs.272295

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