IL17F Antibody

Datasheet
Code CSB-PA842733LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q96PD4
Image
  • IHC image of CSB-PA842733LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Interleukin-17F protein (31-163AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:500-1:1000
Relevance Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Interleukin-17F (IL-17F) (Cytokine ML-1), IL17F
Immunogen Species Human
Research Area Cardiovascular
Target Names IL17F
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Ligand for IL17RA and IL17RC
Involvement in disease Candidiasis, familial, 6 (CANDF6)
Subcellular Location Secreted
Protein Families IL-17 family
Tissue Specificity Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Database Links

HGNC: 16404

OMIM: 606496

KEGG: hsa:112744

STRING: 9606.ENSP00000337432

UniGene: Hs.272295

Pathway IL-17 signaling pathway
Th17 cell differentiation

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