Recombinant Mouse Interleukin-9 protein (Il9) (Active)

1. Results indicated that interleukin 9 (IL-9) was an important type of cytokine involved in the progression of Schistosoma japonicum infection-induced hepatic damage. PMID: 28539607
2. IL9 CNS-25/IL9 CNS-18 is a critical and conserved regulatory element for IL-9 production in mice and humans. PMID: 30442929
3. Data show that interferon regulatory factor 1 (IRF1) occupancy correlates with decreased interferon regulatory factor 4 (IRF4) abundance, suggesting an IRF1-IRF4-binding competition at the interleukin 9 (Il9) locus. PMID: 28497800
4. Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 to both the Il9 and Irf4 promoters and induces their transactivation. PMID: 29339772
5. CXCL10, not CXCL9 or CXCL11, induced IL-9 expression in the liver tissue. PMID: 29860220
6. Chronic kidney disease aggravates vein graft disease through mechanisms involving IL-9 and mast cell activation. PMID: 29048463
7. the results of this study indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest approaches to enhance Th9 activity in beneficial immune responses PMID: 28137893
8. The germinal center development of memory B cells is promoted by follicular helpter T cell-derived IL-9. PMID: 28650481
9. In mice, the absence of IL-9 impaired ILC2 proliferation and activation of regulatory T (Treg) cells, and resulted in chronic arthritis with excessive cartilage destruction and bone loss. PMID: 28714991
10. These data indicate that IL-9 is an essential regulator of megakaryopoiesis and a promising therapeutic agent for treatment of thrombocytopenia such as CIT. PMID: 28450306
11. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. PMID: 26129648
12. Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC. PMID: 26603936
13. IL-9 exerted pro-atherosclerotic effects in ApoE-/- mice at least partially by inducing VCAM-1 expression, which mediated inflammatory cell infiltration into atherosclerotic lesions. PMID: 25784693
14. IL-9 is dispensable for mucosal mast cell development but is necessary for their effective expansion to promote intestinal mastocytosis and susceptibility to experimental food allergy in an IL-9-dependent autocrine manner. PMID: 26410628
15. IL-9 production following chlamydial lung infection is redundant for host defense against the intracellular bacteria PMID: 25646821
16. IL-25-stimulated dendritic cells rapidly induced mediators, such as the chemokine CCL17, which, in turn, attracted IL-9-producing T cells PMID: 26371249
17. TH9 cells are a major source of IL-9 in models of allergic inflammation and play an important role in mast cell accumulation and activation. PMID: 25746972
18. IRF4 binds to the promoters of IL1b and IL9, suggesting that tick-derived sialostatin L suppresses mast cell-derived IL-9 preferentially by inhibiting IRF4. PMID: 26078269
19. these data identify TL1A-DR3 interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A may be a potential therapeutic target in diseases dependent on IL-9. PMID: 25786692
20. Neutralizing IL9 antibody phenocopied the effects of IL9 gene deletion. PMID: 25297635
21. IL-9 can promote interstitial cells of Cajal (ICC) growth and help maintain ICC functions. PMID: 24755995
22. Th2 lymphocytes migrating to the bone marrow under high-altitude hypoxia promote erythropoiesis via activin A and interleukin-9. PMID: 24769210
23. results suggest that Foxp3 Treg suppress sufficient IL-9 production for subsequent mast cell degranulation during S. ratti infection in a non-redundant manner in BALB/c mice PMID: 24516385
24. This study demonstrates that IL-9, through its direct effects on Th1 and ability to promote IL-4 secretion, has a regulatory role for Th1 lymphocytes in allergic contact dermatitis. PMID: 24487305
25. In experimental autoimmune encephalomyelitis, forced expression of BCL6 in myelin oligodendrocyte glycoprotein35-55-specific Th9 cells resulted in decreased IL-9 production and induction of IFN-gamma PMID: 24879792
26. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
27. IL-9 has a unique role as an autocrine amplifier of ILC2 function, promoting tissue repair in the recovery phase after helminth-induced lung inflammation PMID: 24249111
28. TGF-beta signaling regulated IL-9 production through displacement of EZH2 and removal of suppressive H3K27 histone modification at the Il9 locus. PMID: 24108699
29. There is a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection. PMID: 24138883
30. This study demonstrates that intestinal IL-25 promotes protective immunity against T. spiralis infection by inducing antigen-specific Th9 immune response. PMID: 23897610
31. We propose that Smad2/3 and IRF4 cooperatively transactivate the Il9 promoter and play an important role in regulating allergic immune responses by inducing Th9 cells. PMID: 23913959
32. Il9r(-/-) mice showed accelerated tumor growth. Recombinant IL-9 given to tumor-bearing WT & Rag1(-/-) mice inhibited melanoma & lung carcinoma growth, suggesting a role for IL9 in tumor immunity. PMID: 22772464
33. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. PMID: 22892939
34. A PU.1-dependent mechanism alters histone acetylation and expression of the interleukin (Il)9 locus in T helper (Th)9 cells. PMID: 22904310
35. propose that Notch and Smad3 cooperate to induce IL-9 and participate in regulating the immune response PMID: 22503540
36. data established a transcription factor network that regulates IL-9 PMID: 22180613
37. data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells PMID: 22327077
38. production is largely restricted to innate lymphoid cells in experimental lung inflammation PMID: 21983833
39. Data show that IL-9(-/-) mice developed significantly less severe EAE than their WT counterparts. PMID: 21674475
40. data show that neoplastic mast cells (MC) express IL-9 receptors, that IL-9 and NPM-ALK upregulate MC-production in vivo, and that both'hits' act in concert to induce a mastocytosis-like disease in mice PMID: 21297223
41. IL-9-producing CD4-positive T cells are induced in an IL-4-dependent manner. PMID: 21346235
42. results demonstrate a previously unappreciated role for IL-9 in dampening the pathogenic activities of Th17 cells PMID: 21360526
43. The nephroprotective, anti-inflammatory effects of regulatory T cells critically depend on IL-9-mediated attraction of mast cells into kidney-draining lymph nodes. PMID: 21115728
44. protective effect of IL-9 blockade in EAE was likely mediated via inhibition of the development of MOG peptide-specific T cells, which in turn led to reduced infiltration of T cells into the CNS PMID: 20805418
45. data clearly demonstrate the central function of interferon regulatory factor 4 in the development of T helper 9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma. PMID: 20674401
46. the chronic OVA challenge protocol in BALB/c mice provides a model to study the mechanism of bronchial mast cell accumulation, and bronchial mast cell accumulation in chronic OVA challenged mice is independent of IL-9 in this model PMID: 20480160
47. a critical role for PU.1 in generating the IL-9-producing (T(H)9) phenotype and in the development of allergic inflammation PMID: 20431622
48. These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen-induced anaphylaxis. PMID: 20159257
49. IL-25 is a newly identified regulator of IL-9 expression. PMID: 20154671
50. expression in anaplastic large-cell lymphoma PMID: 12555065

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KEGG: mmu:16198

STRING: 10090.ENSMUSP00000022019

UniGene: Mm.3006