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| Code | CSB-MP015044HUc9 |
| Product Type | Other |
| Size | $298 |
| Uniprot No. | Q13421 |
| Relevance | Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. |
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| Molecular Characterization |  |
| Storage Buffer | Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4 |
| Alias | CAK1 antigen (Pre-pro-megakaryocyte-potentiating factor) (Megakaryocyte-potentiating factor) (Mesothelin, cleaved form) (MPF) |
| Species | Homo sapiens (Human) |
| Biological_Activity | Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml. |
| Purity | Greater than 92% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU/ug as determined by LAL method. |
| Sequence | PKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKEVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQG |
| Research Area | Cancer |
| Source | Mammalian cell |
| Gene Names | MSLN |
| Expression Region | 296-580aa |
| Tag Info | N-terminal FC-tagged |
| Mol. Weight | 60.4 kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week. |
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| Function | Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION |
| Involvement in disease | Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. |
| Subcellular Location | Cell membrane, Lipid-anchor, GPI-anchor, Golgi apparatus, SUBCELLULAR LOCATION: Megakaryocyte-potentiating factor: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted |
| Protein Families | Mesothelin family |
| Tissue Specificity | Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). |
| Database Links |
HGNC: 7371 OMIM: 601051 KEGG: hsa:10232 STRING: 9606.ENSP00000372313 UniGene: Hs.408488 |
MSLN Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA10159A0Rb | MSLN Antibody | Human | ELISA, IHC, IF, IP |
| CSB-PA10159B0Rb | MSLN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10159C0Rb | MSLN Antibody, FITC conjugated | Human | ELISA |
| CSB-PA10159D0Rb | MSLN Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA015044ESR1HU | MSLN Antibody | Human | ELISA, WB, IHC |
| CSB-PA015044ESR2HU | MSLN Antibody | Human | ELISA, IHC |
MSLN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA846777 | MSLN Antibody | Human | ELISA,IHC |
| CSB-PA952111 | MSLN Antibody | Human | ELISA,IHC |
MSLN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-MP015044HU | Recombinant Human Mesothelin(MSLN),partial | Mammalian cell |
| CSB-MP015044HUf3 | Recombinant Human Mesothelin(MSLN),partial | Mammalian cell |
| CSB-YP015044HU CSB-EP015044HU CSB-BP015044HU |
Recombinant Human Mesothelin(MSLN) | Yeast E.coli Baculovirus |
MSLN ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E13382h | Human Mesothelin(MSLN)ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/mL |
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