ADCY8 Antibody

1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women PMID: 26480920
2. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion. PMID: 27651839
3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
4. ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory. PMID: 24677629
5. Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. PMID: 23278386
6. The adenylate cyclase 8 plays a major role in cAMP production. PMID: 23200849
7. Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling PMID: 22494970
8. cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. PMID: 21046358
9. Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered. PMID: 20675917
10. Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events. PMID: 20410303
11. The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. PMID: 19691954
12. Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8. PMID: 12890691
13. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A was shown PMID: 16258073
14. recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation PMID: 16613843
15. Redundant cyclase activity maintains the balance between presynaptically silent and active synapses, but AC8 plays an mportant role in resetting the balance of active to silent synapses after adaptation to strong activity. PMID: 18480272
16. Colocalizes with Orai1 and stromal interaction molecule 1 (STIM1) at the plasma membrane in lipid rafts PMID: 19171672

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HGNC: 239

OMIM: 103070

KEGG: hsa:114

STRING: 9606.ENSP00000286355

UniGene: Hs.591859