Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA001344LA01HU |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) ADCY8 Polyclonal antibody | ||||||
| Uniprot No. | P40145 | ||||||
| Target Names | ADCY8 | ||||||
| Alternative Names | ADCY8 antibody; Adenylate cyclase type 8 antibody; EC 4.6.1.1 antibody; ATP pyrophosphate-lyase 8 antibody; Adenylate cyclase type VIII antibody; Adenylyl cyclase 8 antibody; AC8 antibody; Ca(2+)/calmodulin-activated adenylyl cyclase antibody | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human | ||||||
| Immunogen | Recombinant Human Adenylate cyclase type 8 protein (534-670AA) | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated The ADCY8 Antibody (Product code: CSB-PA001344LA01HU) is Non-conjugated. For ADCY8 Antibody with conjugates, please check the following table. |
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| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Purification Method | >95%, Protein G purified | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
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| Form | Liquid | ||||||
| Tested Applications | ELISA, IHC, IF | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
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| Gene References into Functions |
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| Subcellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola. |
| Protein Families | Adenylyl cyclase class-4/guanylyl cyclase family |
| Tissue Specificity | Detected in brain cortex. Expressed in islet. |
| Database Links |
HGNC: 239 OMIM: 103070 KEGG: hsa:114 STRING: 9606.ENSP00000286355 UniGene: Hs.591859 |
