ADCY8 Antibody

Code CSB-PA133805
Size US$297Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 antibody.
  • Immunofluorescence analysis of A549 cells, using ADCY8 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADCY8 Polyclonal antibody
Uniprot No. P40145
Target Names ADCY8
Alternative Names ADCY8 antibody; Adenylate cyclase type 8 antibody; EC antibody; ATP pyrophosphate-lyase 8 antibody; Adenylate cyclase type VIII antibody; Adenylyl cyclase 8 antibody; AC8 antibody; Ca(2+)/calmodulin-activated adenylyl cyclase antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from internal of Human ADCY8.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Gene References into Functions
  1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women PMID: 26480920
  2. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion. PMID: 27651839
  3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
  4. ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory. PMID: 24677629
  5. Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. PMID: 23278386
  6. The adenylate cyclase 8 plays a major role in cAMP production. PMID: 23200849
  7. Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling PMID: 22494970
  8. cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. PMID: 21046358
  9. Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered. PMID: 20675917
  10. Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events. PMID: 20410303
  11. The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. PMID: 19691954
  12. Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8. PMID: 12890691
  13. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A was shown PMID: 16258073
  14. recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation PMID: 16613843
  15. Redundant cyclase activity maintains the balance between presynaptically silent and active synapses, but AC8 plays an mportant role in resetting the balance of active to silent synapses after adaptation to strong activity. PMID: 18480272
  16. Colocalizes with Orai1 and stromal interaction molecule 1 (STIM1) at the plasma membrane in lipid rafts PMID: 19171672

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in brain cortex.
Database Links

HGNC: 239

OMIM: 103070

KEGG: hsa:114

STRING: 9606.ENSP00000286355

UniGene: Hs.591859


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