Recombinant Human Adenylate cyclase type 8(ADCY8) ,partial

Code CSB-YP001344HU
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Source Yeast
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Code CSB-EP001344HU
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Source E.coli
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Code CSB-EP001344HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001344HU
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Source Baculovirus
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Code CSB-MP001344HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ADCY8
Uniprot No. P40145
Alternative Names ADCY8; Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
Species Homo sapiens (Human)
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).
Gene References into Functions
  1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women PMID: 26480920
  2. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion. PMID: 27651839
  3. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
  4. ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory. PMID: 24677629
  5. Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. PMID: 23278386
  6. The adenylate cyclase 8 plays a major role in cAMP production. PMID: 23200849
  7. Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling PMID: 22494970
  8. cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. PMID: 21046358
  9. Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered. PMID: 20675917
  10. Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events. PMID: 20410303
  11. The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. PMID: 19691954
  12. Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8. PMID: 12890691
  13. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A was shown PMID: 16258073
  14. recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation PMID: 16613843
  15. Redundant cyclase activity maintains the balance between presynaptically silent and active synapses, but AC8 plays an mportant role in resetting the balance of active to silent synapses after adaptation to strong activity. PMID: 18480272
  16. Colocalizes with Orai1 and stromal interaction molecule 1 (STIM1) at the plasma membrane in lipid rafts PMID: 19171672

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in brain cortex.
Database Links

HGNC: 239

OMIM: 103070

KEGG: hsa:114

STRING: 9606.ENSP00000286355

UniGene: Hs.591859

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