DDR2 Antibody

Code CSB-PA620985LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, A549 whole cell lysate
    All lanes: DDR2 antibody at 3.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 97 kDa
    Observed band size: 97 kDa

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA620985LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA620985LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DDR2 Polyclonal antibody
Uniprot No. Q16832
Target Names DDR2
Alternative Names CD167 antigen-like family member B antibody; CD167b antibody; CD167b antigen antibody; Cell migration inducing protein 20 antibody; DDR 2 antibody; DDR2 antibody; DDR2_HUMAN antibody; Discoidin domain containing receptor 2 antibody; Discoidin domain receptor 2 antibody; Discoidin domain receptor family member 2 antibody; discoidin domain receptor tyrosine kinase 2 antibody; Discoidin domain-containing receptor 2 antibody; discoidin domain-containing receptor tyrosine kinase 2 antibody; Hydroxyaryl protein kinase antibody; MIG20a antibody; Migration inducing gene 16 protein antibody; Neurotrophic tyrosine kinase antibody; Neurotrophic tyrosine kinase receptor related 3 antibody; NTRKR 3 antibody; NTRKR3 antibody; Receptor protein tyrosine kinase TKT antibody; Receptor protein-tyrosine kinase TKT antibody; Receptor related 3 antibody; receptor-related 3 antibody; TKT antibody; TYRO 10 antibody; TYRO10 antibody; Tyrosine kinase receptor related to neurotrophic TRK antibody; Tyrosine protein kinase TYRO 10 antibody; Tyrosine protein kinase TYRO10 antibody; Tyrosine-protein kinase TYRO10 antibody; Tyrosylprotein kinase antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Discoidin domain-containing receptor 2 protein (447-540AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The DDR2 Antibody (Product code: CSB-PA620985LA01HU) is Non-conjugated. For DDR2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA620985LB01HU DDR2 Antibody, HRP conjugated ELISA
FITC CSB-PA620985LC01HU DDR2 Antibody, FITC conjugated
Biotin CSB-PA620985LD01HU DDR2 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Tyrosine kinase involved in the regulation of tissues remodeling. It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Gene References into Functions
  1. Our data indicate that DDR2 is a potent biomarker that can be used as an effective therapeutic target for treating oral squamous cell carcinoma patients with lymph node metastasis. PMID: 29945346
  2. DDR2 localisation is independent of integrin activation and the key DDR2 signalling effector SHC1. Structure-function analysis reveals that DDR2 mutants defective for collagen binding or kinase activity are unable to localise to the cell surface, demonstrating for the first time that both collagen binding and kinase functions are required for spatial localisation of DDR2. PMID: 29709482
  3. report the identification and characterization of a selective, extracellularly acting small molecule inhibitor (WRG-28) of DDR2 that uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. By targeting DDR2, WRG-28 inhibits tumor invasion and migration PMID: 30061414
  4. Our results suggest that a mutation in DDR2 occurs naturally with a frequency of about 2% in Korean lung SCC patients. In addition, we showed that each of the novel DDR2 mutations were located in a kinase domain and induced an increase in cell proliferation rate. PMID: 28161936
  5. Overexpression of DDR2 might contribute to tumor progression in lung SQCC. The overexpression of DDR2 could be potential molecular target of lung SQCC. PMID: 28676216
  6. DDR2 overexpression is independently associated with tumor progression and poor survival rates in urothelial carcinoma patients. PMID: 27793038
  7. The DDR2 E655K mutation can play a role in cancer progression. PMID: 26826182
  8. collagen II-activated phosphorylated-DDR2 induces CYR61 through activation of transcription factor activator protein 1 (AP-1). The elevated CYR61, in turn, accelerates MMP1 production via ETS1 (ETS proto-oncogene 1). PMID: 27653023
  9. these data suggest that biological collagen aging could increase tumor cell proliferation by reducing the activation of the key matrix sensor DDR2 PMID: 27121132
  10. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis. PMID: 28147276
  11. This study suggested that DDR1 and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 and microglia. PMID: 28863860
  12. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site. PMID: 27264173
  13. The group of patients with colorectal cancer with high DDR2 expression had significantly higher frequencies of T4, lymph node metastasis, and peritoneal dissemination compared to the group with low DDR2 expression. PMID: 28476831
  14. DDR2 showed high expression in gastric cancer tissues and cells. In xenograft models, DDR2 overexpression promoted tumor formation. Furthermore, DDR2 expression impacted on the invasion and motility of GC cells, accompanied by changes in EMT marker expression. Finally, our results revealed that DDR2 facilitates GC cell invasion and EMT through mTORC2 activation and AKT phosphorylation. PMID: 27010547
  15. DDR2 mediates collagen-induced activation of MT1-MMP in human fibroblasts PMID: 28270508
  16. Study strongly suggests that during pulmonary fibrosis, DDR2 not only participates in both the initiation and maintenance of fibrotic reaction, but also affects both ECM production and angiogenesis. PMID: 27350126
  17. signaling pathway, effectively suppressed peritoneal dissemination. DDR2 was identified as a driver gene for Gastric Cancer dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting Gastric Cancer peritoneal dissemination. PMID: 26934957
  18. DDR2 Missense mutation is associated with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type. PMID: 26463668
  19. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl-like proteins that inhibit collagen-DDR interactions and macrophage migration. PMID: 26702058
  20. DDR2 plays an important role in promoting hepatocellular carcinoma cell invasion and migration by stabilizing SNA1. PMID: 26362312
  21. The inhibition of DDR2 by RNA interference suppressed in vivo and in vitro growth of human hepatocellular carcinoma cells. PMID: 25842034
  22. Report correlation between increased radiographic grade of knee osteoarthritis and decreased proportion of cartilage stained for DDR2. PMID: 26191278
  23. Identified are 3 Single Nucleotide Polymorphisms in DDR2 significantly associated with hip bone mineral density in the Chinese population. PMID: 25658585
  24. Defective Ca(2+) binding in a conserved binding site causes incomplete N-glycan processing and endoplasmic reticulum trapping of DDR1 and DDR2 receptors. PMID: 25470979
  25. Data show that discoidin domain receptor 2 (DDR2) is linked to a polyubiquitin (Ub) chain predominantly through lysine K27 conjugation and slightly through K33. PMID: 26271983
  26. In ADSCC patients, DDR2 mutation coexisted with G12C substitution in KRAS gene. PMID: 25173530
  27. peptide delivered by the AuNP-Apt system inhibited cancer cell proliferation and invasion mediated by DDR2 activation PMID: 26067556
  28. A DDR1(Low)/DDR2(High) protein profile is associated with TNBC and may identify invasive carcinomas with worse prognosis. PMID: 25667101
  29. DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review] PMID: 24781958
  30. DDR2 promoted chondrocyte hypertrophy and terminal differentiation. PMID: 24938620
  31. DDR2 plays an important role in head and neck squamous cell carcinoma metastasis, and might be a promising target for future therapies in this type of cancer. PMID: 24556606
  32. These data indicated that the novel DDR2 mutation may contribute to the development and progression of lung SCC and this effect may be associated with increased proliferation and invasiveness, at least in part, via regulating E-cadherin expression. PMID: 24885564
  33. Our results highlight potential RTK-driven adaptive-resistant mechanisms upon DDR2 targeting, and they suggest new, rationale cotargeting strategies for DDR2-mutant lung squamous cell cancer PMID: 25348954
  34. Promising therapeutic opportunities based on existing and novel targeted small molecule inhibitors against DDR2 may provide new strategies for treating lung squamous cell cancer patients. PMID: 24828669
  35. High DDR2 protein expression is associated with recurrence in ameloblastomas. PMID: 24723326
  36. we conclude that DDR2 participates in hypoxia-induced breast cancer metastasis through the regulation of cell migration, invasion, and epithelial-mesenchymal transition PMID: 25130389
  37. In this review we highlight the mechanisms whereby DDRs(DDR1 and DDR2) regulate two important processes, namely inflammation and tissue fibrosis. PMID: 24361528
  38. DDR2 overexpression is associated with neoplasms. PMID: 24740739
  39. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. PMID: 24505276
  40. Discoidin domain receptor 2 facilitates prostate cancer bone metastasis via regulating parathyroid hormone-related protein. PMID: 24787381
  41. Cbl-b, by promoting the ubiquitination and degradation of DDR2, functions as a negative regulator in the DDR2 signaling pathway. PMID: 24631539
  42. A novel missense deletion mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking. PMID: 24725993
  43. regulation of DDRs by glucose PMID: 24018687
  44. Loss of DDR2 suppresses tumor angiogenesis and tumor metastasis to the lung. PMID: 24293323
  45. SHP-2 is a key signalling node downstream of the DDR2 receptor in lung cancer. PMID: 23822953
  46. DDR2 functioning is required for the membrane dynamics to control the mechanical attachment of fibroblasts to the 3D collagen matrices in an integrin-independent manner. PMID: 23546533
  47. DDR2 maintains SNAIL1 level and activity in tumour cells that have undergone epithelial-mesenchymal transition (EMT), thereby facilitating continued tumour cell invasion through collagen-I-rich extracellular matrices by sustaining the EMT phenotype. PMID: 23644467
  48. DDR2 is an independent favorable predictor for prognosis in human breast cancer. PMID: 23307244
  49. Mutations in the DDR2 gene were recently identified in squamous cell lung cancer through a sequencing screen of 201 genes with a potential role in human cancer (including the entire tyrosine kinome). PMID: 23401445
  50. DDR2 regulates directionality through its ability to increase secretion of metalloproteinases and local generation of collagen-derived chemotactic peptide gradients. PMID: 23233663

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Involvement in disease Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL)
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
Database Links

HGNC: 2731

OMIM: 191311

KEGG: hsa:4921

STRING: 9606.ENSP00000356898

UniGene: Hs.275757

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